The usefulness of chromoendoscopy with methylene blue in Barrett’s metaplasia and early esophageal carcinoma
Background Barrett’s esophagus is a condition that is premalignant for adenocarcinoma of the esophagus and the esophagogastric junction. Early detection of Barrett’s metaplasia and dysplasia is very important to decrease the mortality and morbidity from esophageal adenocarcinoma cancer. This study a...
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| Veröffentlicht in: | Surgical endoscopy 2008-03, Vol.22 (3), p.693-700 |
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| creator | Ormeci, N. Savas, B. Coban, S. Palabıyıkoğlu, M. Ensari, A. Kuzu, I. Kursun, N. |
| description | Background
Barrett’s esophagus is a condition that is premalignant for adenocarcinoma of the esophagus and the esophagogastric junction. Early detection of Barrett’s metaplasia and dysplasia is very important to decrease the mortality and morbidity from esophageal adenocarcinoma cancer. This study aimed to evaluate the effectiveness of methylene blue–targeted biopsies in the differential diagnosis of intestinal metaplasia, dysplasia, and superficial esophageal carcinoma.
Methods
A total of 109 patients (43 women and 66 men; average age, 62.32 ± 10.61 years; range, 33–82 years) were enrolled for the study. Four groups were designed before endoscopic examinations. The patients for these groups were selected at the conventional endoscopy, and then chromoendoscopy was performed. The esophagus was stained with methylene blue, after which six biopsies were taken from stained and unstained areas.
Results
Conventional and chromoendoscopic assessments were compared with histopathologic examination. The sensitivity of chromoendoscopy for Barrett’s epithelium was superior to that of conventional endoscopy (
p
< 0.05). However, there was no statistical difference between the two methods in the diagnosis of esophagitis or esophageal carcinoma (
p
> 0.05). Stained biopsies were superior to unstained biopsies in terms of sensitivity for Barrett’s epithelium and esophageal carcinoma (
p
< 0.001).
Conclusion
Chromoendoscopy is useful for delineating Barrett’s epithelium and for indicating the correct location for securing biopsies where dysplasia or early esophageal cancer is suspected. |
| doi_str_mv | 10.1007/s00464-007-9463-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70360989</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70360989</sourcerecordid><originalsourceid>FETCH-LOGICAL-c399t-1c2aa5686c48711cd6e442ecd9929da877fe80301c02cfe02ab631cff9d2863f3</originalsourceid><addsrcrecordid>eNp10c2KFDEQAOAgijuuPoAXCYLeWpN0Jj9HXXZVWPCynkNNurLdSzppk27cufkavp5PYg8zuCB4SkF9VSmqCHnJ2TvOmH5fGZNKNmvYWKna5v4R2XDZikYIbh6TDbMta4S28ow8q_WOrdzy7VNyxrVm0hi9IemmR7pUDEtMWCvNgfq-5DFj6nL1edrTH8Pc0xHnfh8xId3FBemQ6EcoBef5989f9ZCFKUIdgELqKEKJe4o1Tz3cIkTqofgh5RGekycBYsUXp_ecfLu6vLn43Fx__fTl4sN141tr54Z7AbBVRnlpNOe-UyilQN9ZK2wHRuuAhrWMeyZ8QCZgp1ruQ7CdMKoN7Tl5e-w7lfx9wTq7cageY4SEealOs1Yxa-wKX_8D7_JS0jqbE9xKK9nWrIgfkS-51oLBTWUYoewdZ-5wCXe8hDuEh0u4-7Xm1anxshuxe6g4rX4Fb04AqocYCiQ_1L9OMCG04mp14ujqmkq3WB4m_P_vfwAHX6Os</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>219494058</pqid></control><display><type>article</type><title>The usefulness of chromoendoscopy with methylene blue in Barrett’s metaplasia and early esophageal carcinoma</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Ormeci, N. ; Savas, B. ; Coban, S. ; Palabıyıkoğlu, M. ; Ensari, A. ; Kuzu, I. ; Kursun, N.</creator><creatorcontrib>Ormeci, N. ; Savas, B. ; Coban, S. ; Palabıyıkoğlu, M. ; Ensari, A. ; Kuzu, I. ; Kursun, N.</creatorcontrib><description>Background
Barrett’s esophagus is a condition that is premalignant for adenocarcinoma of the esophagus and the esophagogastric junction. Early detection of Barrett’s metaplasia and dysplasia is very important to decrease the mortality and morbidity from esophageal adenocarcinoma cancer. This study aimed to evaluate the effectiveness of methylene blue–targeted biopsies in the differential diagnosis of intestinal metaplasia, dysplasia, and superficial esophageal carcinoma.
Methods
A total of 109 patients (43 women and 66 men; average age, 62.32 ± 10.61 years; range, 33–82 years) were enrolled for the study. Four groups were designed before endoscopic examinations. The patients for these groups were selected at the conventional endoscopy, and then chromoendoscopy was performed. The esophagus was stained with methylene blue, after which six biopsies were taken from stained and unstained areas.
Results
Conventional and chromoendoscopic assessments were compared with histopathologic examination. The sensitivity of chromoendoscopy for Barrett’s epithelium was superior to that of conventional endoscopy (
p
< 0.05). However, there was no statistical difference between the two methods in the diagnosis of esophagitis or esophageal carcinoma (
p
> 0.05). Stained biopsies were superior to unstained biopsies in terms of sensitivity for Barrett’s epithelium and esophageal carcinoma (
p
< 0.001).
Conclusion
Chromoendoscopy is useful for delineating Barrett’s epithelium and for indicating the correct location for securing biopsies where dysplasia or early esophageal cancer is suspected.</description><identifier>ISSN: 0930-2794</identifier><identifier>EISSN: 1432-2218</identifier><identifier>DOI: 10.1007/s00464-007-9463-x</identifier><identifier>PMID: 17704887</identifier><identifier>CODEN: SUREEX</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Abdominal Surgery ; Adult ; Aged ; Aged, 80 and over ; Barrett Esophagus - diagnosis ; Barrett Esophagus - pathology ; Biological and medical sciences ; Biopsy, Needle ; Carcinoma, Squamous Cell - diagnosis ; Carcinoma, Squamous Cell - pathology ; Cohort Studies ; Diagnosis, Differential ; Digestive system. Abdomen ; Endoscopy ; Esophageal Neoplasms - diagnosis ; Esophageal Neoplasms - pathology ; Esophagoscopy - methods ; Esophagus ; Female ; Follow-Up Studies ; Gastroenterology ; Gastroenterology. Liver. Pancreas. Abdomen ; General aspects ; Gynecology ; Hepatology ; Humans ; Immunohistochemistry ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Methylene Blue ; Middle Aged ; Other diseases. Semiology ; Precancerous Conditions - diagnosis ; Precancerous Conditions - pathology ; Proctology ; Risk Assessment ; Sensitivity and Specificity ; Staining and Labeling - methods ; Surgery</subject><ispartof>Surgical endoscopy, 2008-03, Vol.22 (3), p.693-700</ispartof><rights>Springer Science+Business Media, LLC 2007</rights><rights>2008 INIST-CNRS</rights><rights>Springer Science+Business Media, LLC 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-1c2aa5686c48711cd6e442ecd9929da877fe80301c02cfe02ab631cff9d2863f3</citedby><cites>FETCH-LOGICAL-c399t-1c2aa5686c48711cd6e442ecd9929da877fe80301c02cfe02ab631cff9d2863f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00464-007-9463-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00464-007-9463-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20227616$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17704887$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ormeci, N.</creatorcontrib><creatorcontrib>Savas, B.</creatorcontrib><creatorcontrib>Coban, S.</creatorcontrib><creatorcontrib>Palabıyıkoğlu, M.</creatorcontrib><creatorcontrib>Ensari, A.</creatorcontrib><creatorcontrib>Kuzu, I.</creatorcontrib><creatorcontrib>Kursun, N.</creatorcontrib><title>The usefulness of chromoendoscopy with methylene blue in Barrett’s metaplasia and early esophageal carcinoma</title><title>Surgical endoscopy</title><addtitle>Surg Endosc</addtitle><addtitle>Surg Endosc</addtitle><description>Background
Barrett’s esophagus is a condition that is premalignant for adenocarcinoma of the esophagus and the esophagogastric junction. Early detection of Barrett’s metaplasia and dysplasia is very important to decrease the mortality and morbidity from esophageal adenocarcinoma cancer. This study aimed to evaluate the effectiveness of methylene blue–targeted biopsies in the differential diagnosis of intestinal metaplasia, dysplasia, and superficial esophageal carcinoma.
Methods
A total of 109 patients (43 women and 66 men; average age, 62.32 ± 10.61 years; range, 33–82 years) were enrolled for the study. Four groups were designed before endoscopic examinations. The patients for these groups were selected at the conventional endoscopy, and then chromoendoscopy was performed. The esophagus was stained with methylene blue, after which six biopsies were taken from stained and unstained areas.
Results
Conventional and chromoendoscopic assessments were compared with histopathologic examination. The sensitivity of chromoendoscopy for Barrett’s epithelium was superior to that of conventional endoscopy (
p
< 0.05). However, there was no statistical difference between the two methods in the diagnosis of esophagitis or esophageal carcinoma (
p
> 0.05). Stained biopsies were superior to unstained biopsies in terms of sensitivity for Barrett’s epithelium and esophageal carcinoma (
p
< 0.001).
Conclusion
Chromoendoscopy is useful for delineating Barrett’s epithelium and for indicating the correct location for securing biopsies where dysplasia or early esophageal cancer is suspected.</description><subject>Abdominal Surgery</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Barrett Esophagus - diagnosis</subject><subject>Barrett Esophagus - pathology</subject><subject>Biological and medical sciences</subject><subject>Biopsy, Needle</subject><subject>Carcinoma, Squamous Cell - diagnosis</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Cohort Studies</subject><subject>Diagnosis, Differential</subject><subject>Digestive system. Abdomen</subject><subject>Endoscopy</subject><subject>Esophageal Neoplasms - diagnosis</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Esophagoscopy - methods</subject><subject>Esophagus</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gastroenterology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>General aspects</subject><subject>Gynecology</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Methylene Blue</subject><subject>Middle Aged</subject><subject>Other diseases. Semiology</subject><subject>Precancerous Conditions - diagnosis</subject><subject>Precancerous Conditions - pathology</subject><subject>Proctology</subject><subject>Risk Assessment</subject><subject>Sensitivity and Specificity</subject><subject>Staining and Labeling - methods</subject><subject>Surgery</subject><issn>0930-2794</issn><issn>1432-2218</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp10c2KFDEQAOAgijuuPoAXCYLeWpN0Jj9HXXZVWPCynkNNurLdSzppk27cufkavp5PYg8zuCB4SkF9VSmqCHnJ2TvOmH5fGZNKNmvYWKna5v4R2XDZikYIbh6TDbMta4S28ow8q_WOrdzy7VNyxrVm0hi9IemmR7pUDEtMWCvNgfq-5DFj6nL1edrTH8Pc0xHnfh8xId3FBemQ6EcoBef5989f9ZCFKUIdgELqKEKJe4o1Tz3cIkTqofgh5RGekycBYsUXp_ecfLu6vLn43Fx__fTl4sN141tr54Z7AbBVRnlpNOe-UyilQN9ZK2wHRuuAhrWMeyZ8QCZgp1ruQ7CdMKoN7Tl5e-w7lfx9wTq7cageY4SEealOs1Yxa-wKX_8D7_JS0jqbE9xKK9nWrIgfkS-51oLBTWUYoewdZ-5wCXe8hDuEh0u4-7Xm1anxshuxe6g4rX4Fb04AqocYCiQ_1L9OMCG04mp14ujqmkq3WB4m_P_vfwAHX6Os</recordid><startdate>20080301</startdate><enddate>20080301</enddate><creator>Ormeci, N.</creator><creator>Savas, B.</creator><creator>Coban, S.</creator><creator>Palabıyıkoğlu, M.</creator><creator>Ensari, A.</creator><creator>Kuzu, I.</creator><creator>Kursun, N.</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20080301</creationdate><title>The usefulness of chromoendoscopy with methylene blue in Barrett’s metaplasia and early esophageal carcinoma</title><author>Ormeci, N. ; Savas, B. ; Coban, S. ; Palabıyıkoğlu, M. ; Ensari, A. ; Kuzu, I. ; Kursun, N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-1c2aa5686c48711cd6e442ecd9929da877fe80301c02cfe02ab631cff9d2863f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Abdominal Surgery</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Barrett Esophagus - diagnosis</topic><topic>Barrett Esophagus - pathology</topic><topic>Biological and medical sciences</topic><topic>Biopsy, Needle</topic><topic>Carcinoma, Squamous Cell - diagnosis</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Cohort Studies</topic><topic>Diagnosis, Differential</topic><topic>Digestive system. Abdomen</topic><topic>Endoscopy</topic><topic>Esophageal Neoplasms - diagnosis</topic><topic>Esophageal Neoplasms - pathology</topic><topic>Esophagoscopy - methods</topic><topic>Esophagus</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gastroenterology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>General aspects</topic><topic>Gynecology</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Methylene Blue</topic><topic>Middle Aged</topic><topic>Other diseases. Semiology</topic><topic>Precancerous Conditions - diagnosis</topic><topic>Precancerous Conditions - pathology</topic><topic>Proctology</topic><topic>Risk Assessment</topic><topic>Sensitivity and Specificity</topic><topic>Staining and Labeling - methods</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ormeci, N.</creatorcontrib><creatorcontrib>Savas, B.</creatorcontrib><creatorcontrib>Coban, S.</creatorcontrib><creatorcontrib>Palabıyıkoğlu, M.</creatorcontrib><creatorcontrib>Ensari, A.</creatorcontrib><creatorcontrib>Kuzu, I.</creatorcontrib><creatorcontrib>Kursun, N.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Surgical endoscopy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ormeci, N.</au><au>Savas, B.</au><au>Coban, S.</au><au>Palabıyıkoğlu, M.</au><au>Ensari, A.</au><au>Kuzu, I.</au><au>Kursun, N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The usefulness of chromoendoscopy with methylene blue in Barrett’s metaplasia and early esophageal carcinoma</atitle><jtitle>Surgical endoscopy</jtitle><stitle>Surg Endosc</stitle><addtitle>Surg Endosc</addtitle><date>2008-03-01</date><risdate>2008</risdate><volume>22</volume><issue>3</issue><spage>693</spage><epage>700</epage><pages>693-700</pages><issn>0930-2794</issn><eissn>1432-2218</eissn><coden>SUREEX</coden><abstract>Background
Barrett’s esophagus is a condition that is premalignant for adenocarcinoma of the esophagus and the esophagogastric junction. Early detection of Barrett’s metaplasia and dysplasia is very important to decrease the mortality and morbidity from esophageal adenocarcinoma cancer. This study aimed to evaluate the effectiveness of methylene blue–targeted biopsies in the differential diagnosis of intestinal metaplasia, dysplasia, and superficial esophageal carcinoma.
Methods
A total of 109 patients (43 women and 66 men; average age, 62.32 ± 10.61 years; range, 33–82 years) were enrolled for the study. Four groups were designed before endoscopic examinations. The patients for these groups were selected at the conventional endoscopy, and then chromoendoscopy was performed. The esophagus was stained with methylene blue, after which six biopsies were taken from stained and unstained areas.
Results
Conventional and chromoendoscopic assessments were compared with histopathologic examination. The sensitivity of chromoendoscopy for Barrett’s epithelium was superior to that of conventional endoscopy (
p
< 0.05). However, there was no statistical difference between the two methods in the diagnosis of esophagitis or esophageal carcinoma (
p
> 0.05). Stained biopsies were superior to unstained biopsies in terms of sensitivity for Barrett’s epithelium and esophageal carcinoma (
p
< 0.001).
Conclusion
Chromoendoscopy is useful for delineating Barrett’s epithelium and for indicating the correct location for securing biopsies where dysplasia or early esophageal cancer is suspected.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>17704887</pmid><doi>10.1007/s00464-007-9463-x</doi><tpages>8</tpages></addata></record> |
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| subjects | Abdominal Surgery Adult Aged Aged, 80 and over Barrett Esophagus - diagnosis Barrett Esophagus - pathology Biological and medical sciences Biopsy, Needle Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - pathology Cohort Studies Diagnosis, Differential Digestive system. Abdomen Endoscopy Esophageal Neoplasms - diagnosis Esophageal Neoplasms - pathology Esophagoscopy - methods Esophagus Female Follow-Up Studies Gastroenterology Gastroenterology. Liver. Pancreas. Abdomen General aspects Gynecology Hepatology Humans Immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Medicine Medicine & Public Health Methylene Blue Middle Aged Other diseases. Semiology Precancerous Conditions - diagnosis Precancerous Conditions - pathology Proctology Risk Assessment Sensitivity and Specificity Staining and Labeling - methods Surgery |
| title | The usefulness of chromoendoscopy with methylene blue in Barrett’s metaplasia and early esophageal carcinoma |
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