JUN Oncogene Amplification and Overexpression Block Adipocytic Differentiation in Highly Aggressive Sarcomas

The human oncogene JUN encodes a component of the AP-1 complex and is consequently involved in a wide range of pivotal cellular processes, including cell proliferation, transformation, and apoptosis. Nevertheless, despite extensive analyses of its functions, it has never been directly involved in a...

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Veröffentlicht in:	Cancer cell 2007-04, Vol.11 (4), p.361-374
Hauptverfasser:	Mariani, Odette, Brennetot, Caroline, Coindre, Jean-Michel, Gruel, Nadège, Ganem, Carine, Delattre, Olivier, Stern, Marc-Henri, Aurias, Alain
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells Adipocytes - metabolism Adipocytes - pathology Adipogenesis Aged Animals Cell Differentiation CELLCYCLE Chromosomes, Artificial, Bacterial Chromosomes, Human, Pair 1 - genetics Female Gene Amplification Gene Expression Profiling Gene Expression Regulation Humans Liposarcoma - genetics Liposarcoma - metabolism Liposarcoma - pathology Mice Mice, Nude Proto-Oncogene Proteins c-jun - genetics Proto-Oncogene Proteins c-jun - metabolism Retroperitoneal Neoplasms - genetics Retroperitoneal Neoplasms - metabolism Retroperitoneal Neoplasms - pathology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism
Online-Zugang:	Volltext
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