JUN Oncogene Amplification and Overexpression Block Adipocytic Differentiation in Highly Aggressive Sarcomas
The human oncogene JUN encodes a component of the AP-1 complex and is consequently involved in a wide range of pivotal cellular processes, including cell proliferation, transformation, and apoptosis. Nevertheless, despite extensive analyses of its functions, it has never been directly involved in a...
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| Veröffentlicht in: | Cancer cell 2007-04, Vol.11 (4), p.361-374 |
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| creator | Mariani, Odette Brennetot, Caroline Coindre, Jean-Michel Gruel, Nadège Ganem, Carine Delattre, Olivier Stern, Marc-Henri Aurias, Alain |
| description | The human oncogene JUN encodes a component of the AP-1 complex and is consequently involved in a wide range of pivotal cellular processes, including cell proliferation, transformation, and apoptosis. Nevertheless, despite extensive analyses of its functions, it has never been directly involved in a human cancer. We demonstrate here that it is highly amplified and overexpressed in undifferentiated and aggressive human sarcomas, which are blocked at an early step of adipocyte differentiation. We confirm by cellular and xenograft mouse models recapitulating these sarcoma genetics that the failure to differentiate is dependent upon JUN amplification/overexpression. |
| doi_str_mv | 10.1016/j.ccr.2007.02.007 |
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We confirm by cellular and xenograft mouse models recapitulating these sarcoma genetics that the failure to differentiate is dependent upon JUN amplification/overexpression.</description><identifier>ISSN: 1535-6108</identifier><identifier>EISSN: 1878-3686</identifier><identifier>DOI: 10.1016/j.ccr.2007.02.007</identifier><identifier>PMID: 17418412</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>3T3-L1 Cells ; Adipocytes - metabolism ; Adipocytes - pathology ; Adipogenesis ; Aged ; Animals ; Cell Differentiation ; CELLCYCLE ; Chromosomes, Artificial, Bacterial ; Chromosomes, Human, Pair 1 - genetics ; Female ; Gene Amplification ; Gene Expression Profiling ; Gene Expression Regulation ; Humans ; Liposarcoma - genetics ; Liposarcoma - metabolism ; Liposarcoma - pathology ; Mice ; Mice, Nude ; Proto-Oncogene Proteins c-jun - genetics ; Proto-Oncogene Proteins c-jun - metabolism ; Retroperitoneal Neoplasms - genetics ; Retroperitoneal Neoplasms - metabolism ; Retroperitoneal Neoplasms - pathology ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - genetics ; RNA, Messenger - metabolism</subject><ispartof>Cancer cell, 2007-04, Vol.11 (4), p.361-374</ispartof><rights>2007 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-1eda868cef0f1598cfb35be93214697ec5f88432289328c1c5e0baf2f2c9aab33</citedby><cites>FETCH-LOGICAL-c491t-1eda868cef0f1598cfb35be93214697ec5f88432289328c1c5e0baf2f2c9aab33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ccr.2007.02.007$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17418412$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mariani, Odette</creatorcontrib><creatorcontrib>Brennetot, Caroline</creatorcontrib><creatorcontrib>Coindre, Jean-Michel</creatorcontrib><creatorcontrib>Gruel, Nadège</creatorcontrib><creatorcontrib>Ganem, Carine</creatorcontrib><creatorcontrib>Delattre, Olivier</creatorcontrib><creatorcontrib>Stern, Marc-Henri</creatorcontrib><creatorcontrib>Aurias, Alain</creatorcontrib><title>JUN Oncogene Amplification and Overexpression Block Adipocytic Differentiation in Highly Aggressive Sarcomas</title><title>Cancer cell</title><addtitle>Cancer Cell</addtitle><description>The human oncogene JUN encodes a component of the AP-1 complex and is consequently involved in a wide range of pivotal cellular processes, including cell proliferation, transformation, and apoptosis. 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We confirm by cellular and xenograft mouse models recapitulating these sarcoma genetics that the failure to differentiate is dependent upon JUN amplification/overexpression.</description><subject>3T3-L1 Cells</subject><subject>Adipocytes - metabolism</subject><subject>Adipocytes - pathology</subject><subject>Adipogenesis</subject><subject>Aged</subject><subject>Animals</subject><subject>Cell Differentiation</subject><subject>CELLCYCLE</subject><subject>Chromosomes, Artificial, Bacterial</subject><subject>Chromosomes, Human, Pair 1 - genetics</subject><subject>Female</subject><subject>Gene Amplification</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation</subject><subject>Humans</subject><subject>Liposarcoma - genetics</subject><subject>Liposarcoma - metabolism</subject><subject>Liposarcoma - pathology</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>Proto-Oncogene Proteins c-jun - genetics</subject><subject>Proto-Oncogene Proteins c-jun - metabolism</subject><subject>Retroperitoneal Neoplasms - genetics</subject><subject>Retroperitoneal Neoplasms - metabolism</subject><subject>Retroperitoneal Neoplasms - pathology</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><issn>1535-6108</issn><issn>1878-3686</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU-P0zAUxC0EYv_AB-CCfOKWYDuJY4tT2WVZ0IoeYM-W8_JcXJI42GlFvz0urcQNTvP09Js5zBDyirOSMy7fbkuAWArG2pKJMssTcslVq4pKKvk0303VFJIzdUGuUtqy7OGtfk4ueFtzVXNxSYbPj1_oeoKwwQnpapwH7zzYxYeJ2qmn6z1G_DVHTOn4ej8E-EFXvZ8DHBYP9NY7l4lp8SePn-i933wfDnS12fxx7ZF-tRHCaNML8szZIeHLs16Tx7sP327ui4f1x083q4cCas2XgmNvlVSAjjneaAWuq5oOdSV4LXWL0Dil6koIlV8KODTIOuuEE6Ct7arqmrw55c4x_NxhWszoE-Aw2AnDLpmWVZLV8v8g11LrmukM8hMIMaQU0Zk5-tHGg-HMHLcwW5O3MMctDBMmS_a8PofvuhH7v45z-Rl4dwIwd7H3GE0CjxNg7yPCYvrg_xH_G8Rhm0U</recordid><startdate>20070401</startdate><enddate>20070401</enddate><creator>Mariani, Odette</creator><creator>Brennetot, Caroline</creator><creator>Coindre, Jean-Michel</creator><creator>Gruel, Nadège</creator><creator>Ganem, Carine</creator><creator>Delattre, Olivier</creator><creator>Stern, Marc-Henri</creator><creator>Aurias, Alain</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20070401</creationdate><title>JUN Oncogene Amplification and Overexpression Block Adipocytic Differentiation in Highly Aggressive Sarcomas</title><author>Mariani, Odette ; Brennetot, Caroline ; Coindre, Jean-Michel ; Gruel, Nadège ; Ganem, Carine ; Delattre, Olivier ; Stern, Marc-Henri ; Aurias, Alain</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-1eda868cef0f1598cfb35be93214697ec5f88432289328c1c5e0baf2f2c9aab33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>3T3-L1 Cells</topic><topic>Adipocytes - metabolism</topic><topic>Adipocytes - pathology</topic><topic>Adipogenesis</topic><topic>Aged</topic><topic>Animals</topic><topic>Cell Differentiation</topic><topic>CELLCYCLE</topic><topic>Chromosomes, Artificial, Bacterial</topic><topic>Chromosomes, Human, Pair 1 - genetics</topic><topic>Female</topic><topic>Gene Amplification</topic><topic>Gene Expression Profiling</topic><topic>Gene Expression Regulation</topic><topic>Humans</topic><topic>Liposarcoma - genetics</topic><topic>Liposarcoma - metabolism</topic><topic>Liposarcoma - pathology</topic><topic>Mice</topic><topic>Mice, Nude</topic><topic>Proto-Oncogene Proteins c-jun - genetics</topic><topic>Proto-Oncogene Proteins c-jun - metabolism</topic><topic>Retroperitoneal Neoplasms - genetics</topic><topic>Retroperitoneal Neoplasms - metabolism</topic><topic>Retroperitoneal Neoplasms - pathology</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mariani, Odette</creatorcontrib><creatorcontrib>Brennetot, Caroline</creatorcontrib><creatorcontrib>Coindre, Jean-Michel</creatorcontrib><creatorcontrib>Gruel, Nadège</creatorcontrib><creatorcontrib>Ganem, Carine</creatorcontrib><creatorcontrib>Delattre, Olivier</creatorcontrib><creatorcontrib>Stern, Marc-Henri</creatorcontrib><creatorcontrib>Aurias, Alain</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mariani, Odette</au><au>Brennetot, Caroline</au><au>Coindre, Jean-Michel</au><au>Gruel, Nadège</au><au>Ganem, Carine</au><au>Delattre, Olivier</au><au>Stern, Marc-Henri</au><au>Aurias, Alain</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>JUN Oncogene Amplification and Overexpression Block Adipocytic Differentiation in Highly Aggressive Sarcomas</atitle><jtitle>Cancer cell</jtitle><addtitle>Cancer Cell</addtitle><date>2007-04-01</date><risdate>2007</risdate><volume>11</volume><issue>4</issue><spage>361</spage><epage>374</epage><pages>361-374</pages><issn>1535-6108</issn><eissn>1878-3686</eissn><abstract>The human oncogene JUN encodes a component of the AP-1 complex and is consequently involved in a wide range of pivotal cellular processes, including cell proliferation, transformation, and apoptosis. Nevertheless, despite extensive analyses of its functions, it has never been directly involved in a human cancer. We demonstrate here that it is highly amplified and overexpressed in undifferentiated and aggressive human sarcomas, which are blocked at an early step of adipocyte differentiation. We confirm by cellular and xenograft mouse models recapitulating these sarcoma genetics that the failure to differentiate is dependent upon JUN amplification/overexpression.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>17418412</pmid><doi>10.1016/j.ccr.2007.02.007</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Cell Press Free Archives; EZB-FREE-00999 freely available EZB journals |
| subjects | 3T3-L1 Cells Adipocytes - metabolism Adipocytes - pathology Adipogenesis Aged Animals Cell Differentiation CELLCYCLE Chromosomes, Artificial, Bacterial Chromosomes, Human, Pair 1 - genetics Female Gene Amplification Gene Expression Profiling Gene Expression Regulation Humans Liposarcoma - genetics Liposarcoma - metabolism Liposarcoma - pathology Mice Mice, Nude Proto-Oncogene Proteins c-jun - genetics Proto-Oncogene Proteins c-jun - metabolism Retroperitoneal Neoplasms - genetics Retroperitoneal Neoplasms - metabolism Retroperitoneal Neoplasms - pathology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism |
| title | JUN Oncogene Amplification and Overexpression Block Adipocytic Differentiation in Highly Aggressive Sarcomas |
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