The Drosophila Circadian Network Is a Seasonal Timer
Previous work in Drosophila has defined two populations of circadian brain neurons, morning cells (M-cells) and evening cells (E-cells), both of which keep circadian time and regulate morning and evening activity, respectively. It has long been speculated that a multiple oscillator circadian network...
Gespeichert in:
| Veröffentlicht in: | Cell 2007-04, Vol.129 (1), p.207-219 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 219 |
|---|---|
| container_issue | 1 |
| container_start_page | 207 |
| container_title | Cell |
| container_volume | 129 |
| creator | Stoleru, Dan Nawathean, Pipat Fernández, María de la Paz Menet, Jerome S. Ceriani, M. Fernanda Rosbash, Michael |
| description | Previous work in
Drosophila has defined two populations of circadian brain neurons, morning cells (M-cells) and evening cells (E-cells), both of which keep circadian time and regulate morning and evening activity, respectively. It has long been speculated that a multiple oscillator circadian network in animals underlies the behavioral and physiological pattern variability caused by seasonal fluctuations of photoperiod. We have manipulated separately the circadian photoentrainment pathway within E- and M-cells and show that E-cells process light information and function as master clocks in the presence of light. M-cells in contrast need darkness to cycle autonomously and dominate the network. The results indicate that the network switches control between these two centers as a function of photoperiod. Together with the different entraining properties of the two clock centers, the results suggest that the functional organization of the network underlies the behavioral adjustment to variations in daylength and season. |
| doi_str_mv | 10.1016/j.cell.2007.02.038 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70359955</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0092867407003145</els_id><sourcerecordid>70359955</sourcerecordid><originalsourceid>FETCH-LOGICAL-c495t-c822ed84d056391e55b41226967837a2e3330cb39991b8256142e8d08cbda88e3</originalsourceid><addsrcrecordid>eNqFkL1OwzAYRS0EoqXwAgwoE1vCZzuObYkFlV-pgoEyW47zVXXJT7FbEG9PolZig-ku517pHkLOKWQUaHG1yhzWdcYAZAYsA64OyJiClmlOJTskYwDNUlXIfEROYlwBgBJCHJMRlTlVUhdjks-XmNyGLnbrpa9tMvXB2crbNnnGzVcX3pOnmNjkFW3sWlsnc99gOCVHC1tHPNvnhLzd382nj-ns5eFpejNLXa7FJnWKMaxUXoEouKYoRJlTxgpdSMWlZcg5B1dyrTUtFRMFzRmqCpQrK6sU8gm53O2uQ_exxbgxjY_DZ9tit41GAhdaC_EvSHWhFVOsB9kOdP3lGHBh1sE3NnwbCmaQalZm6JlBqgFmeql96WK_vi0brH4re4s9cL0DsJfx6TGY6Dy2Disf0G1M1fm_9n8A_CWFXQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19698282</pqid></control><display><type>article</type><title>The Drosophila Circadian Network Is a Seasonal Timer</title><source>MEDLINE</source><source>Open Access: Cell Press Free Archives</source><source>Elsevier ScienceDirect Journals</source><source>EZB Electronic Journals Library</source><creator>Stoleru, Dan ; Nawathean, Pipat ; Fernández, María de la Paz ; Menet, Jerome S. ; Ceriani, M. Fernanda ; Rosbash, Michael</creator><creatorcontrib>Stoleru, Dan ; Nawathean, Pipat ; Fernández, María de la Paz ; Menet, Jerome S. ; Ceriani, M. Fernanda ; Rosbash, Michael</creatorcontrib><description>Previous work in
Drosophila has defined two populations of circadian brain neurons, morning cells (M-cells) and evening cells (E-cells), both of which keep circadian time and regulate morning and evening activity, respectively. It has long been speculated that a multiple oscillator circadian network in animals underlies the behavioral and physiological pattern variability caused by seasonal fluctuations of photoperiod. We have manipulated separately the circadian photoentrainment pathway within E- and M-cells and show that E-cells process light information and function as master clocks in the presence of light. M-cells in contrast need darkness to cycle autonomously and dominate the network. The results indicate that the network switches control between these two centers as a function of photoperiod. Together with the different entraining properties of the two clock centers, the results suggest that the functional organization of the network underlies the behavioral adjustment to variations in daylength and season.</description><identifier>ISSN: 0092-8674</identifier><identifier>EISSN: 1097-4172</identifier><identifier>DOI: 10.1016/j.cell.2007.02.038</identifier><identifier>PMID: 17418796</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Behavior, Animal ; Biological Clocks - physiology ; Brain - cytology ; Brain - physiology ; Circadian Rhythm - physiology ; Cryptochromes ; Drosophila ; Drosophila melanogaster - physiology ; Drosophila Proteins - genetics ; Drosophila Proteins - metabolism ; Eye Proteins - metabolism ; Glycogen Synthase Kinase 3 - genetics ; Glycogen Synthase Kinase 3 - metabolism ; Light ; MOLNEURO ; Motor Activity ; Neurons - physiology ; Photoperiod ; Receptors, G-Protein-Coupled - metabolism ; Seasons ; SYSNEURO</subject><ispartof>Cell, 2007-04, Vol.129 (1), p.207-219</ispartof><rights>2007 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c495t-c822ed84d056391e55b41226967837a2e3330cb39991b8256142e8d08cbda88e3</citedby><cites>FETCH-LOGICAL-c495t-c822ed84d056391e55b41226967837a2e3330cb39991b8256142e8d08cbda88e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0092867407003145$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17418796$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stoleru, Dan</creatorcontrib><creatorcontrib>Nawathean, Pipat</creatorcontrib><creatorcontrib>Fernández, María de la Paz</creatorcontrib><creatorcontrib>Menet, Jerome S.</creatorcontrib><creatorcontrib>Ceriani, M. Fernanda</creatorcontrib><creatorcontrib>Rosbash, Michael</creatorcontrib><title>The Drosophila Circadian Network Is a Seasonal Timer</title><title>Cell</title><addtitle>Cell</addtitle><description>Previous work in
Drosophila has defined two populations of circadian brain neurons, morning cells (M-cells) and evening cells (E-cells), both of which keep circadian time and regulate morning and evening activity, respectively. It has long been speculated that a multiple oscillator circadian network in animals underlies the behavioral and physiological pattern variability caused by seasonal fluctuations of photoperiod. We have manipulated separately the circadian photoentrainment pathway within E- and M-cells and show that E-cells process light information and function as master clocks in the presence of light. M-cells in contrast need darkness to cycle autonomously and dominate the network. The results indicate that the network switches control between these two centers as a function of photoperiod. Together with the different entraining properties of the two clock centers, the results suggest that the functional organization of the network underlies the behavioral adjustment to variations in daylength and season.</description><subject>Animals</subject><subject>Behavior, Animal</subject><subject>Biological Clocks - physiology</subject><subject>Brain - cytology</subject><subject>Brain - physiology</subject><subject>Circadian Rhythm - physiology</subject><subject>Cryptochromes</subject><subject>Drosophila</subject><subject>Drosophila melanogaster - physiology</subject><subject>Drosophila Proteins - genetics</subject><subject>Drosophila Proteins - metabolism</subject><subject>Eye Proteins - metabolism</subject><subject>Glycogen Synthase Kinase 3 - genetics</subject><subject>Glycogen Synthase Kinase 3 - metabolism</subject><subject>Light</subject><subject>MOLNEURO</subject><subject>Motor Activity</subject><subject>Neurons - physiology</subject><subject>Photoperiod</subject><subject>Receptors, G-Protein-Coupled - metabolism</subject><subject>Seasons</subject><subject>SYSNEURO</subject><issn>0092-8674</issn><issn>1097-4172</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkL1OwzAYRS0EoqXwAgwoE1vCZzuObYkFlV-pgoEyW47zVXXJT7FbEG9PolZig-ku517pHkLOKWQUaHG1yhzWdcYAZAYsA64OyJiClmlOJTskYwDNUlXIfEROYlwBgBJCHJMRlTlVUhdjks-XmNyGLnbrpa9tMvXB2crbNnnGzVcX3pOnmNjkFW3sWlsnc99gOCVHC1tHPNvnhLzd382nj-ns5eFpejNLXa7FJnWKMaxUXoEouKYoRJlTxgpdSMWlZcg5B1dyrTUtFRMFzRmqCpQrK6sU8gm53O2uQ_exxbgxjY_DZ9tit41GAhdaC_EvSHWhFVOsB9kOdP3lGHBh1sE3NnwbCmaQalZm6JlBqgFmeql96WK_vi0brH4re4s9cL0DsJfx6TGY6Dy2Disf0G1M1fm_9n8A_CWFXQ</recordid><startdate>20070406</startdate><enddate>20070406</enddate><creator>Stoleru, Dan</creator><creator>Nawathean, Pipat</creator><creator>Fernández, María de la Paz</creator><creator>Menet, Jerome S.</creator><creator>Ceriani, M. Fernanda</creator><creator>Rosbash, Michael</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20070406</creationdate><title>The Drosophila Circadian Network Is a Seasonal Timer</title><author>Stoleru, Dan ; Nawathean, Pipat ; Fernández, María de la Paz ; Menet, Jerome S. ; Ceriani, M. Fernanda ; Rosbash, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c495t-c822ed84d056391e55b41226967837a2e3330cb39991b8256142e8d08cbda88e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Behavior, Animal</topic><topic>Biological Clocks - physiology</topic><topic>Brain - cytology</topic><topic>Brain - physiology</topic><topic>Circadian Rhythm - physiology</topic><topic>Cryptochromes</topic><topic>Drosophila</topic><topic>Drosophila melanogaster - physiology</topic><topic>Drosophila Proteins - genetics</topic><topic>Drosophila Proteins - metabolism</topic><topic>Eye Proteins - metabolism</topic><topic>Glycogen Synthase Kinase 3 - genetics</topic><topic>Glycogen Synthase Kinase 3 - metabolism</topic><topic>Light</topic><topic>MOLNEURO</topic><topic>Motor Activity</topic><topic>Neurons - physiology</topic><topic>Photoperiod</topic><topic>Receptors, G-Protein-Coupled - metabolism</topic><topic>Seasons</topic><topic>SYSNEURO</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stoleru, Dan</creatorcontrib><creatorcontrib>Nawathean, Pipat</creatorcontrib><creatorcontrib>Fernández, María de la Paz</creatorcontrib><creatorcontrib>Menet, Jerome S.</creatorcontrib><creatorcontrib>Ceriani, M. Fernanda</creatorcontrib><creatorcontrib>Rosbash, Michael</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stoleru, Dan</au><au>Nawathean, Pipat</au><au>Fernández, María de la Paz</au><au>Menet, Jerome S.</au><au>Ceriani, M. Fernanda</au><au>Rosbash, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Drosophila Circadian Network Is a Seasonal Timer</atitle><jtitle>Cell</jtitle><addtitle>Cell</addtitle><date>2007-04-06</date><risdate>2007</risdate><volume>129</volume><issue>1</issue><spage>207</spage><epage>219</epage><pages>207-219</pages><issn>0092-8674</issn><eissn>1097-4172</eissn><abstract>Previous work in
Drosophila has defined two populations of circadian brain neurons, morning cells (M-cells) and evening cells (E-cells), both of which keep circadian time and regulate morning and evening activity, respectively. It has long been speculated that a multiple oscillator circadian network in animals underlies the behavioral and physiological pattern variability caused by seasonal fluctuations of photoperiod. We have manipulated separately the circadian photoentrainment pathway within E- and M-cells and show that E-cells process light information and function as master clocks in the presence of light. M-cells in contrast need darkness to cycle autonomously and dominate the network. The results indicate that the network switches control between these two centers as a function of photoperiod. Together with the different entraining properties of the two clock centers, the results suggest that the functional organization of the network underlies the behavioral adjustment to variations in daylength and season.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>17418796</pmid><doi>10.1016/j.cell.2007.02.038</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0092-8674 |
| ispartof | Cell, 2007-04, Vol.129 (1), p.207-219 |
| issn | 0092-8674 1097-4172 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70359955 |
| source | MEDLINE; Open Access: Cell Press Free Archives; Elsevier ScienceDirect Journals; EZB Electronic Journals Library |
| subjects | Animals Behavior, Animal Biological Clocks - physiology Brain - cytology Brain - physiology Circadian Rhythm - physiology Cryptochromes Drosophila Drosophila melanogaster - physiology Drosophila Proteins - genetics Drosophila Proteins - metabolism Eye Proteins - metabolism Glycogen Synthase Kinase 3 - genetics Glycogen Synthase Kinase 3 - metabolism Light MOLNEURO Motor Activity Neurons - physiology Photoperiod Receptors, G-Protein-Coupled - metabolism Seasons SYSNEURO |
| title | The Drosophila Circadian Network Is a Seasonal Timer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T11%3A10%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Drosophila%20Circadian%20Network%20Is%20a%20Seasonal%20Timer&rft.jtitle=Cell&rft.au=Stoleru,%20Dan&rft.date=2007-04-06&rft.volume=129&rft.issue=1&rft.spage=207&rft.epage=219&rft.pages=207-219&rft.issn=0092-8674&rft.eissn=1097-4172&rft_id=info:doi/10.1016/j.cell.2007.02.038&rft_dat=%3Cproquest_cross%3E70359955%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=19698282&rft_id=info:pmid/17418796&rft_els_id=S0092867407003145&rfr_iscdi=true |