CLIP-domain serine proteases in Drosophila innate immunity
Extracellular proteases play an important role in a wide range of host physiological events, such as food digestion, extracellular matrix degradation, coagulation and immunity. Among the large extracellular protease family, serine proteases that contain a "paper clip'-like domain and are t...
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| Veröffentlicht in: | BMB reports 2008, 41(2), , pp.102-107 |
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| creator | Jang, I.H. (Ewha Womans University, Seoul, Republic of Korea) Nam, H.J. (Ewha Womans University, Seoul, Republic of Korea) Lee, W.J. (Ewha Womans University, Seoul, Republic of Korea), E-mail: lwj@ewha.ac.kr |
| description | Extracellular proteases play an important role in a wide range of host physiological events, such as food digestion, extracellular matrix degradation, coagulation and immunity. Among the large extracellular protease family, serine proteases that contain a "paper clip'-like domain and are therefore referred to as CLIP-domain serine protease (clip-SP), have been found to be involved in unique biological processes, such as immunity and development. Despite the increasing amount of biochemical information available regarding the structure and function of clip-SPs, their in vivo physiological significance is not well known due to a lack of genetic studies. Recently, Drosophila has been shown to be a powerful genetic model system for the dissection of biological functions of the clip-SPs at the organism level. Here, the current knowledge regarding Drosophila clip-SPs has been summarized and future research directions to evaluate the role that clip-SPs play in Drosophila immunity are discussed. |
| doi_str_mv | 10.5483/bmbrep.2008.41.2.102 |
| format | Article |
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(Ewha Womans University, Seoul, Republic of Korea) ; Nam, H.J. (Ewha Womans University, Seoul, Republic of Korea) ; Lee, W.J. (Ewha Womans University, Seoul, Republic of Korea), E-mail: lwj@ewha.ac.kr</creator><creatorcontrib>Jang, I.H. (Ewha Womans University, Seoul, Republic of Korea) ; Nam, H.J. (Ewha Womans University, Seoul, Republic of Korea) ; Lee, W.J. (Ewha Womans University, Seoul, Republic of Korea), E-mail: lwj@ewha.ac.kr</creatorcontrib><description>Extracellular proteases play an important role in a wide range of host physiological events, such as food digestion, extracellular matrix degradation, coagulation and immunity. Among the large extracellular protease family, serine proteases that contain a "paper clip'-like domain and are therefore referred to as CLIP-domain serine protease (clip-SP), have been found to be involved in unique biological processes, such as immunity and development. Despite the increasing amount of biochemical information available regarding the structure and function of clip-SPs, their in vivo physiological significance is not well known due to a lack of genetic studies. Recently, Drosophila has been shown to be a powerful genetic model system for the dissection of biological functions of the clip-SPs at the organism level. 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Despite the increasing amount of biochemical information available regarding the structure and function of clip-SPs, their in vivo physiological significance is not well known due to a lack of genetic studies. Recently, Drosophila has been shown to be a powerful genetic model system for the dissection of biological functions of the clip-SPs at the organism level. Here, the current knowledge regarding Drosophila clip-SPs has been summarized and future research directions to evaluate the role that clip-SPs play in Drosophila immunity are discussed.</description><subject>Animals</subject><subject>CLIP domain</subject><subject>DROSOPHILA</subject><subject>Drosophila - enzymology</subject><subject>Drosophila - immunology</subject><subject>Immunity, Innate</subject><subject>pro-phenoloxidase</subject><subject>Protein Structure, Tertiary</subject><subject>Serine Endopeptidases - physiology</subject><subject>serine protease</subject><subject>tol</subject><subject>생물학</subject><issn>1976-6696</issn><issn>1225-8687</issn><issn>0219-1024</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtPAjEUhRujEUT_gRpWxs2MbW_nUXeALyJGQ3DddDotVpiH7bDg31uExNV9ffck5yB0SXCcsBzuiqpwuo0pxnnMSExjgukR6mNKeBRadoz6hGdplKY87aEz778xTgnN6CnqkRxIwhnro_vJbPoRlU0lbT302tlaD1vXdFp67Ydh9-Aa37Rfdi3DVMtOD21VbWrbbc_RiZFrry8OdYA-nx4Xk5do9v48nYxmkUoodBEHhXUCNC-ygiRGUcOznMsyU0aRgrDCSMVJKRNjdElZwfMEACgwXhoFksAA3e51a2fESlnRSPtXl41YOTGaL6YiywBSCOjNHg0Wfjbad6KyXun1Wta62XiRYUhCJjiAbA-qYM87bUTrbCXdVhAsdvGK8dt4rluxi1cwImg40PB2fdDfFJUu_58OeQbgag8Y2Qi5dNaL1_lOA2NIGYFfB7R_cA</recordid><startdate>20080229</startdate><enddate>20080229</enddate><creator>Jang, I.H. 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| source | MEDLINE; DOAJ Directory of Open Access Journals; Free Full-Text Journals in Chemistry |
| subjects | Animals CLIP domain DROSOPHILA Drosophila - enzymology Drosophila - immunology Immunity, Innate pro-phenoloxidase Protein Structure, Tertiary Serine Endopeptidases - physiology serine protease tol 생물학 |
| title | CLIP-domain serine proteases in Drosophila innate immunity |
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