The significance of p53 and retinoblastoma pathways in canine hemangiosarcoma

To investigate whether inactivation of the p53 and retinoblastoma (Rb) protein pathways contributes to the development of canine hemangiosarcoma (HSA), we examined immunohistochemically the expression of p53, Rb, phosphorylated Rb (phospho-Rb), p16 , and cyclin D1 in 39 spontaneous canine HSAs and 1...

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Veröffentlicht in:	Journal of Veterinary Medical Science 2007, Vol.69(3), pp.271-278
Hauptverfasser:	Yonemaru, K.(Gifu Univ. (Japan). Faculty of Applied Biological Sciences), Sakai, H, Murakami, M, Kodama, A, Mori, T, Yanai, T, Maruo, K, Masegi, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence canine hemangiosarcoma CHIEN cyclin D1 Cyclin D1 - genetics Cyclin D1 - metabolism Cyclin-Dependent Kinase Inhibitor p16 - metabolism DNA Primers Dog Diseases - metabolism DOGS ENFERMEDADES VASCULARES GENE GENES Hemangiosarcoma - metabolism Hemangiosarcoma - veterinary HISTOPATHOLOGIE HISTOPATHOLOGY HISTOPATOLOGIA Immunohistochemistry - veterinary IMMUNOLOGICAL TECHNIQUES MALADIE VASCULAIRE Molecular Sequence Data p16 p53 PERRO Polymorphism, Single-Stranded Conformational Retinoblastoma Protein - metabolism Reverse Transcriptase Polymerase Chain Reaction - veterinary SARCOMA SARCOME Sequence Analysis, DNA - veterinary Signal Transduction - physiology TECHNIQUE IMMUNOLOGIQUE TECNICAS INMUNOLOGICAS Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism VASCULAR DISEASES
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