APOC3 Promoter Polymorphisms C-482T and T-455C Are Associated with the Metabolic Syndrome
Background Despite the growing epidemic of the metabolic syndrome (MetS), few studies have evaluated genetic polymorphisms associated with the MetS phenotype. One candidate, APOC3, modulates lipid and lipoprotein metabolism and the promoter polymorphisms C-482T/T-455C are associated with loss of ins...
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| Veröffentlicht in: | Archives of medical research 2007-05, Vol.38 (4), p.444-451 |
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| creator | Miller, Michael Rhyne, Jeffrey Chen, Hegang Beach, Valerie Ericson, Richard Luthra, Kalpana Dwivedi, Manjari Misra, Anoop |
| description | Background Despite the growing epidemic of the metabolic syndrome (MetS), few studies have evaluated genetic polymorphisms associated with the MetS phenotype. One candidate, APOC3, modulates lipid and lipoprotein metabolism and the promoter polymorphisms C-482T/T-455C are associated with loss of insulin downregulation. Methods One hundred twenty two consecutive MetS cases were matched by age, sex and race in a 1:1 case-control design to evaluate the prevalence of common polymorphisms in the following candidate genes: APOC3, APOE, B3AR, FABP2, GNB3, LPL , and PPARα and PPARγ. Results Compared to controls, MetS subjects exhibited a greater prevalence of APOC3 promoter polymorphisms. Specifically, the frequency of the variant C-482T and T-455C alleles was 70.5 and 81.9% of cases compared to 43.4 and 54.1% in controls, respectively ( p |
| doi_str_mv | 10.1016/j.arcmed.2006.10.013 |
| format | Article |
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One candidate, APOC3, modulates lipid and lipoprotein metabolism and the promoter polymorphisms C-482T/T-455C are associated with loss of insulin downregulation. Methods One hundred twenty two consecutive MetS cases were matched by age, sex and race in a 1:1 case-control design to evaluate the prevalence of common polymorphisms in the following candidate genes: APOC3, APOE, B3AR, FABP2, GNB3, LPL , and PPARα and PPARγ. Results Compared to controls, MetS subjects exhibited a greater prevalence of APOC3 promoter polymorphisms. Specifically, the frequency of the variant C-482T and T-455C alleles was 70.5 and 81.9% of cases compared to 43.4 and 54.1% in controls, respectively ( p <0.0001). Overall, APOC3 promoter variants were associated with a greater likelihood of MetS compared to wild type [C-482T (OR: 4.3; 95% CI: 2.2, 8.6 [ p <0.0001]), T-455C (OR: 3.6; 95% CI: 2.0, 6.7 [ p <0.0001])]. No material differences were identified between the other genetic variants tested and prevalence of MetS. Conclusions These data, therefore, suggest that the APOC3 promoter polymorphisms C-482T and T-455C are associated with the MetS.</description><identifier>ISSN: 0188-4409</identifier><identifier>DOI: 10.1016/j.arcmed.2006.10.013</identifier><identifier>PMID: 17416293</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Apolipoprotein C-III - genetics ; Female ; Genetic Predisposition to Disease ; Humans ; Internal Medicine ; Male ; Metabolic Syndrome - genetics ; Middle Aged ; Polymorphism, Genetic ; Promoter Regions, Genetic - genetics</subject><ispartof>Archives of medical research, 2007-05, Vol.38 (4), p.444-451</ispartof><rights>IMSS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-7c97c6403cace1f93d581a2f8d9f17592456dc48e996d5486c841735721b28663</citedby><cites>FETCH-LOGICAL-c406t-7c97c6403cace1f93d581a2f8d9f17592456dc48e996d5486c841735721b28663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17416293$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miller, Michael</creatorcontrib><creatorcontrib>Rhyne, Jeffrey</creatorcontrib><creatorcontrib>Chen, Hegang</creatorcontrib><creatorcontrib>Beach, Valerie</creatorcontrib><creatorcontrib>Ericson, Richard</creatorcontrib><creatorcontrib>Luthra, Kalpana</creatorcontrib><creatorcontrib>Dwivedi, Manjari</creatorcontrib><creatorcontrib>Misra, Anoop</creatorcontrib><title>APOC3 Promoter Polymorphisms C-482T and T-455C Are Associated with the Metabolic Syndrome</title><title>Archives of medical research</title><addtitle>Arch Med Res</addtitle><description>Background Despite the growing epidemic of the metabolic syndrome (MetS), few studies have evaluated genetic polymorphisms associated with the MetS phenotype. One candidate, APOC3, modulates lipid and lipoprotein metabolism and the promoter polymorphisms C-482T/T-455C are associated with loss of insulin downregulation. Methods One hundred twenty two consecutive MetS cases were matched by age, sex and race in a 1:1 case-control design to evaluate the prevalence of common polymorphisms in the following candidate genes: APOC3, APOE, B3AR, FABP2, GNB3, LPL , and PPARα and PPARγ. Results Compared to controls, MetS subjects exhibited a greater prevalence of APOC3 promoter polymorphisms. Specifically, the frequency of the variant C-482T and T-455C alleles was 70.5 and 81.9% of cases compared to 43.4 and 54.1% in controls, respectively ( p <0.0001). Overall, APOC3 promoter variants were associated with a greater likelihood of MetS compared to wild type [C-482T (OR: 4.3; 95% CI: 2.2, 8.6 [ p <0.0001]), T-455C (OR: 3.6; 95% CI: 2.0, 6.7 [ p <0.0001])]. No material differences were identified between the other genetic variants tested and prevalence of MetS. Conclusions These data, therefore, suggest that the APOC3 promoter polymorphisms C-482T and T-455C are associated with the MetS.</description><subject>Adult</subject><subject>Apolipoprotein C-III - genetics</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Metabolic Syndrome - genetics</subject><subject>Middle Aged</subject><subject>Polymorphism, Genetic</subject><subject>Promoter Regions, Genetic - genetics</subject><issn>0188-4409</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kU-P0zAQxX0AscvCN0DIJ27pjv_Edi5IVcQC0qKttOXAyXKdieqSxMVOQf32OGq1p5Fm3nvS_B4hHxisGDB1f1i55EfsVhxAldUKmHhFboEZU0kJzQ15m_MBAIxU-g25YVoyxRtxS36tN0-toJsUxzhjops4nMeYjvuQx0zbShq-pW7q6LaSdd3SdUK6zjn64Gbs6L8w7-m8R_oDZ7eLQ_D0-Tx1JQ3fkde9GzK-v8478vPhy7b9Vj0-ff3erh8rL0HNlfaN9kqC8M4j6xvR1YY53puu6ZmuGy5r1XlpsGlUV0ujvJFMi1pztuNGKXFHPl1yjyn-OWGe7Riyx2FwE8ZTthpEbbiBIpQXoU8x54S9PaYwunS2DOyC0R7sBaNdMC7bgrHYPl7zT7vl9mK6MiyCzxcBli__BkzWD2EK3g2_8Yz5EE9pKgAss5lbsM9LK0spoEshQgrxH6pag9Y</recordid><startdate>20070501</startdate><enddate>20070501</enddate><creator>Miller, Michael</creator><creator>Rhyne, Jeffrey</creator><creator>Chen, Hegang</creator><creator>Beach, Valerie</creator><creator>Ericson, Richard</creator><creator>Luthra, Kalpana</creator><creator>Dwivedi, Manjari</creator><creator>Misra, Anoop</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070501</creationdate><title>APOC3 Promoter Polymorphisms C-482T and T-455C Are Associated with the Metabolic Syndrome</title><author>Miller, Michael ; Rhyne, Jeffrey ; Chen, Hegang ; Beach, Valerie ; Ericson, Richard ; Luthra, Kalpana ; Dwivedi, Manjari ; Misra, Anoop</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-7c97c6403cace1f93d581a2f8d9f17592456dc48e996d5486c841735721b28663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Apolipoprotein C-III - genetics</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Metabolic Syndrome - genetics</topic><topic>Middle Aged</topic><topic>Polymorphism, Genetic</topic><topic>Promoter Regions, Genetic - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miller, Michael</creatorcontrib><creatorcontrib>Rhyne, Jeffrey</creatorcontrib><creatorcontrib>Chen, Hegang</creatorcontrib><creatorcontrib>Beach, Valerie</creatorcontrib><creatorcontrib>Ericson, Richard</creatorcontrib><creatorcontrib>Luthra, Kalpana</creatorcontrib><creatorcontrib>Dwivedi, Manjari</creatorcontrib><creatorcontrib>Misra, Anoop</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of medical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miller, Michael</au><au>Rhyne, Jeffrey</au><au>Chen, Hegang</au><au>Beach, Valerie</au><au>Ericson, Richard</au><au>Luthra, Kalpana</au><au>Dwivedi, Manjari</au><au>Misra, Anoop</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>APOC3 Promoter Polymorphisms C-482T and T-455C Are Associated with the Metabolic Syndrome</atitle><jtitle>Archives of medical research</jtitle><addtitle>Arch Med Res</addtitle><date>2007-05-01</date><risdate>2007</risdate><volume>38</volume><issue>4</issue><spage>444</spage><epage>451</epage><pages>444-451</pages><issn>0188-4409</issn><abstract>Background Despite the growing epidemic of the metabolic syndrome (MetS), few studies have evaluated genetic polymorphisms associated with the MetS phenotype. One candidate, APOC3, modulates lipid and lipoprotein metabolism and the promoter polymorphisms C-482T/T-455C are associated with loss of insulin downregulation. Methods One hundred twenty two consecutive MetS cases were matched by age, sex and race in a 1:1 case-control design to evaluate the prevalence of common polymorphisms in the following candidate genes: APOC3, APOE, B3AR, FABP2, GNB3, LPL , and PPARα and PPARγ. Results Compared to controls, MetS subjects exhibited a greater prevalence of APOC3 promoter polymorphisms. Specifically, the frequency of the variant C-482T and T-455C alleles was 70.5 and 81.9% of cases compared to 43.4 and 54.1% in controls, respectively ( p <0.0001). Overall, APOC3 promoter variants were associated with a greater likelihood of MetS compared to wild type [C-482T (OR: 4.3; 95% CI: 2.2, 8.6 [ p <0.0001]), T-455C (OR: 3.6; 95% CI: 2.0, 6.7 [ p <0.0001])]. No material differences were identified between the other genetic variants tested and prevalence of MetS. Conclusions These data, therefore, suggest that the APOC3 promoter polymorphisms C-482T and T-455C are associated with the MetS.</abstract><cop>United States</cop><pmid>17416293</pmid><doi>10.1016/j.arcmed.2006.10.013</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Apolipoprotein C-III - genetics Female Genetic Predisposition to Disease Humans Internal Medicine Male Metabolic Syndrome - genetics Middle Aged Polymorphism, Genetic Promoter Regions, Genetic - genetics |
| title | APOC3 Promoter Polymorphisms C-482T and T-455C Are Associated with the Metabolic Syndrome |
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