Nearly identical strains of human herpesvirus 8 in couples discordant for Kaposi's sarcoma

Transmission of human herpesvirus 8 (HHV-8) may occur through various routes including breastfeeding and sexual intercourse. We attempted to detect HHV-8 infection in nine HIV-positive couples discordant for Kaposi's sarcoma who maintained a monogamous sexual relationship for at least one year....

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Veröffentlicht in:	AIDS (London) 2007-03, Vol.21 (6), p.765-768
Hauptverfasser:	KOURI, Vivian, MARINI, Alessandra, NAMBIAR, Sandeep, RODRIGUEZ, Maria E, CAPO, Virginia, RESIK, Sonia, MANTECON, Beatriz, MARTINEZ, Ariel, KOHLER-HANSNER, Karin J, HENGGE, Ulrich R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult AIDS/HIV Antiretroviral Therapy, Highly Active Biological and medical sciences Cohort Studies Dermatology DNA, Viral - analysis Epidemiology. Vaccinations Female General aspects Genotype Herpesvirus 8, Human - isolation & purification HIV Seropositivity - complications HIV Seropositivity - drug therapy HIV Seropositivity - virology Human herpesvirus 8 Human immunodeficiency virus Human viral diseases Humans Infectious diseases Leukocytes, Mononuclear - virology Male Medical sciences Middle Aged Polymerase Chain Reaction - methods Sarcoma, Kaposi - complications Sarcoma, Kaposi - virology Sequence Homology, Amino Acid Sexual Behavior Tumors of the skin and soft tissue. Premalignant lesions Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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Zusammenfassung:	Transmission of human herpesvirus 8 (HHV-8) may occur through various routes including breastfeeding and sexual intercourse. We attempted to detect HHV-8 infection in nine HIV-positive couples discordant for Kaposi's sarcoma who maintained a monogamous sexual relationship for at least one year. By quantitative real-time polymerase chain reaction and HHV-8 genotyping we provide strong evidence for the sexual transmission of HHV-8 in this unique cohort.
ISSN:	0269-9370 1473-5571
DOI:	10.1097/QAD.0b013e328031f450