Endocrine Outcomes for Children With Embryonal Brain Tumors After Risk-Adapted Craniospinal and Conformal Primary-Site Irradiation and High-Dose Chemotherapy With Stem-Cell Rescue on the SJMB-96 Trial

To estimate the cumulative incidence of specific hormone deficiencies and the influence of hypothalamic-pituitary (HP) axis radiation dose in a cohort of children with embryonal brain tumors treated with risk-adapted craniospinal irradiation (CSI), conformal primary site irradiation, and high-dose c...

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Veröffentlicht in:	Journal of clinical oncology 2008-03, Vol.26 (7), p.1112-1118
Hauptverfasser:	Laughton, Stephen J, Merchant, Thomas E, Sklar, Charles A, Kun, Larry E, Fouladi, Maryam, Broniscer, Alberto, Morris, E Brannon, Sanders, Robert P, Krasin, Matthew J, Shelso, John, Xiong, Zang, Wallace, Dana, Gajjar, Amar
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adrenocorticotropic Hormone - deficiency Adult Biological and medical sciences Brain Neoplasms - complications Brain Neoplasms - drug therapy Brain Neoplasms - radiotherapy Child Child, Preschool Cohort Studies Cranial Irradiation Female Hematopoietic Stem Cells Human Growth Hormone - deficiency Humans Hypothyroidism - epidemiology Hypothyroidism - etiology Male Medical sciences Neoplasms, Germ Cell and Embryonal - complications Neoplasms, Germ Cell and Embryonal - drug therapy Neoplasms, Germ Cell and Embryonal - radiotherapy Neurology Pituitary Gland - drug effects Pituitary Gland - radiation effects Prospective Studies Risk Factors Spinal Cord - radiation effects Thyrotropin - deficiency Tumors Tumors of the nervous system. Phacomatoses
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