Distinct Target-Derived Signals Organize Formation, Maturation, and Maintenance of Motor Nerve Terminals

Target-derived factors organize synaptogenesis by promoting differentiation of nerve terminals at synaptic sites. Several candidate organizing molecules have been identified based on their bioactivities in vitro, but little is known about their roles in vivo. Here, we show that three sets of organiz...

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Veröffentlicht in:	Cell 2007-04, Vol.129 (1), p.179-193
Hauptverfasser:	Fox, Michael A., Sanes, Joshua R., Borza, Dorin-Bogdan, Eswarakumar, Veraragavan P., Fässler, Reinhard, Hudson, Billy G., John, Simon W.M., Ninomiya, Yoshifumi, Pedchenko, Vadim, Pfaff, Samuel L., Rheault, Michelle N., Sado, Yoshikazu, Segal, Yoav, Werle, Michael J., Umemori, Hisashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoantigens - metabolism Cells, Cultured Chick Embryo Coculture Techniques Collagen Type IV - genetics Collagen Type IV - metabolism DEVBIO Fibroblast Growth Factors - metabolism Humans Laminin - genetics Laminin - metabolism Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Transgenic MOLNEURO Motor Neurons - cytology Motor Neurons - metabolism Myoblasts - cytology Myoblasts - metabolism Neuromuscular Junction - embryology Neuromuscular Junction - metabolism Presynaptic Terminals - metabolism Recombinant Proteins - metabolism
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