Rasagiline improves freezing in a patient with primary progressive freezing gait
We herein report the case of a 84‐year‐old man with a 4‐year history of freezing of gait (FOG) consistent with the diagnosis of primary progressive freezing gait. Single photon emission tomography (SPECT) with a radiolabeled ligand of the dopamine transporter (DAT‐SPECT) showed integrity of striatal...
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| Veröffentlicht in: | Movement disorders 2008-02, Vol.23 (3), p.449-451 |
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| container_title | Movement disorders |
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| creator | Coria, Francisco Cozar-Santiago, María del Puig |
| description | We herein report the case of a 84‐year‐old man with a 4‐year history of freezing of gait (FOG) consistent with the diagnosis of primary progressive freezing gait. Single photon emission tomography (SPECT) with a radiolabeled ligand of the dopamine transporter (DAT‐SPECT) showed integrity of striatal dopaminergic terminals, whereas brain perfusion SPECT disclosed multiple areas of decreased perfusion in frontal and parietal lobes, as well as in the subcortical gray nuclei of both sides. Treatment with the new irreversible monoamine oxidase B inhibitor rasagiline at standard doses resulted in a rapid, dramatic, and sustained improvement of the frequency and duration of FOG episodes. In addition, brain perfusion SPECT after treatment showed a marked increase of the activity in all cortical areas as well as in the basal ganglia and thalamus. Rasagiline may prove to be an effective and safe treatment for this disabling condition. © 2007 Movement Disorder Society |
| doi_str_mv | 10.1002/mds.21868 |
| format | Article |
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Single photon emission tomography (SPECT) with a radiolabeled ligand of the dopamine transporter (DAT‐SPECT) showed integrity of striatal dopaminergic terminals, whereas brain perfusion SPECT disclosed multiple areas of decreased perfusion in frontal and parietal lobes, as well as in the subcortical gray nuclei of both sides. Treatment with the new irreversible monoamine oxidase B inhibitor rasagiline at standard doses resulted in a rapid, dramatic, and sustained improvement of the frequency and duration of FOG episodes. In addition, brain perfusion SPECT after treatment showed a marked increase of the activity in all cortical areas as well as in the basal ganglia and thalamus. 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Disord</addtitle><description>We herein report the case of a 84‐year‐old man with a 4‐year history of freezing of gait (FOG) consistent with the diagnosis of primary progressive freezing gait. Single photon emission tomography (SPECT) with a radiolabeled ligand of the dopamine transporter (DAT‐SPECT) showed integrity of striatal dopaminergic terminals, whereas brain perfusion SPECT disclosed multiple areas of decreased perfusion in frontal and parietal lobes, as well as in the subcortical gray nuclei of both sides. Treatment with the new irreversible monoamine oxidase B inhibitor rasagiline at standard doses resulted in a rapid, dramatic, and sustained improvement of the frequency and duration of FOG episodes. In addition, brain perfusion SPECT after treatment showed a marked increase of the activity in all cortical areas as well as in the basal ganglia and thalamus. Rasagiline may prove to be an effective and safe treatment for this disabling condition. © 2007 Movement Disorder Society</description><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - drug effects</subject><subject>brain perfusion SPECT</subject><subject>Disease Progression</subject><subject>freezing of gait</subject><subject>Gait Disorders, Neurologic - diagnostic imaging</subject><subject>Gait Disorders, Neurologic - drug therapy</subject><subject>Gait Disorders, Neurologic - physiopathology</subject><subject>Humans</subject><subject>Indans - therapeutic use</subject><subject>Male</subject><subject>MAOB inhibitors</subject><subject>Medical sciences</subject><subject>Monoamine Oxidase Inhibitors - therapeutic use</subject><subject>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</subject><subject>Neurology</subject><subject>primary progressive freezing gait</subject><subject>rasagiline</subject><subject>Tomography, Emission-Computed, Single-Photon - methods</subject><issn>0885-3185</issn><issn>1531-8257</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0E1v1DAQBmALgei2cOAPoFxA6iHtjB1_5EgLLUjlQ1CJozWbTBZDkl3sbEv59Rg2tCfEaS7PzGu_QjxBOEIAeTy06UiiM-6eWKBWWDqp7X2xAOd0qdDpPbGf0lcARI3modhDB8bmhYX48JESrUIfRi7CsInrK05FF5l_hnFVhLGgYkNT4HEqrsP0pdjEMFC8yXO9ipxSuOI7vqIwPRIPOuoTP57ngbg8e3V5-rq8eH_-5vTFRdlUUrpSL1VDmlrdOGA0EivVtaarXL2swXSmtdAZZyoCaeu6IkmtRJAKaqt4CepAPN-dzQ_5vuU0-SGkhvueRl5vk7egtJEa_wsloqylqTM83MEmrlOK3Pn5rx7B_67Z55r9n5qzfTof3S4Hbu_k3GsGz2ZAqaG-izQ2Id06CWhdTs7ueOeuQ883_070b19--htd7jZCmvjH7QbFb95YZbX__O7c13giz5ytPKpfzBKh8w</recordid><startdate>20080215</startdate><enddate>20080215</enddate><creator>Coria, Francisco</creator><creator>Cozar-Santiago, María del Puig</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20080215</creationdate><title>Rasagiline improves freezing in a patient with primary progressive freezing gait</title><author>Coria, Francisco ; Cozar-Santiago, María del Puig</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4228-5b3ca5ad5c80e162143fd6f489b906f6d70f6864a027994a2ad210230973eb03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - drug effects</topic><topic>brain perfusion SPECT</topic><topic>Disease Progression</topic><topic>freezing of gait</topic><topic>Gait Disorders, Neurologic - diagnostic imaging</topic><topic>Gait Disorders, Neurologic - drug therapy</topic><topic>Gait Disorders, Neurologic - physiopathology</topic><topic>Humans</topic><topic>Indans - therapeutic use</topic><topic>Male</topic><topic>MAOB inhibitors</topic><topic>Medical sciences</topic><topic>Monoamine Oxidase Inhibitors - therapeutic use</topic><topic>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</topic><topic>Neurology</topic><topic>primary progressive freezing gait</topic><topic>rasagiline</topic><topic>Tomography, Emission-Computed, Single-Photon - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Coria, Francisco</creatorcontrib><creatorcontrib>Cozar-Santiago, María del Puig</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Movement disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Coria, Francisco</au><au>Cozar-Santiago, María del Puig</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rasagiline improves freezing in a patient with primary progressive freezing gait</atitle><jtitle>Movement disorders</jtitle><addtitle>Mov. 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| ispartof | Movement disorders, 2008-02, Vol.23 (3), p.449-451 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged, 80 and over Biological and medical sciences Brain - diagnostic imaging Brain - drug effects brain perfusion SPECT Disease Progression freezing of gait Gait Disorders, Neurologic - diagnostic imaging Gait Disorders, Neurologic - drug therapy Gait Disorders, Neurologic - physiopathology Humans Indans - therapeutic use Male MAOB inhibitors Medical sciences Monoamine Oxidase Inhibitors - therapeutic use Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology primary progressive freezing gait rasagiline Tomography, Emission-Computed, Single-Photon - methods |
| title | Rasagiline improves freezing in a patient with primary progressive freezing gait |
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