Mesothelin Promotes Anchorage-Independent Growth and Prevents Anoikis via Extracellular Signal-Regulated Kinase Signaling Pathway in Human Breast Cancer Cells

Mesothelin (MSLN) is a glycoprotein that is overexpressed in various tumors. MSLN is present on the cell surface and is also released into body fluids or culture supernatants from MSLN-positive tumor cells. Despite intensive study of MSLN as a diagnostic marker or target for immunotherapy, its biolo...

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Veröffentlicht in:	Molecular cancer research 2008-02, Vol.6 (2), p.186-193
Hauptverfasser:	Uehara, Norihisa, Matsuoka, Yoichiro, Tsubura, Airo
Format:	Artikel
Sprache:	eng
Schlagworte:	anchorage-independent growth anoikis Anoikis - drug effects Apoptosis Regulatory Proteins - metabolism Bcl-2-Like Protein 11 Bim breast cancer Breast Neoplasms - enzymology Breast Neoplasms - genetics Breast Neoplasms - pathology Butadienes - pharmacology Cell Adhesion - drug effects Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Female Gene Expression Regulation, Neoplastic - drug effects GPI-Linked Proteins Humans MAP Kinase Signaling System - drug effects Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Membrane Proteins - metabolism mesothelin Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Nitriles - pharmacology Phosphorylation - drug effects Proto-Oncogene Proteins - metabolism
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