Abundant eosinophil infiltration in a neurofibroma
We report a case of sporadic cutaneous neurofibroma showing diffuse eosinophil infiltration in a 72-year-old woman. The neurofibroma had been on the skin of the left anterior shoulder for approximately 10 years. The presence of mast cells is well known in neurofibroma. However, infiltration of neuro...
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| Veröffentlicht in: | The American journal of dermatopathology 2007-04, Vol.29 (2), p.187-189 |
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| container_title | The American journal of dermatopathology |
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| creator | Hong, Seung Phil Ahn, Sung Ku |
| description | We report a case of sporadic cutaneous neurofibroma showing diffuse eosinophil infiltration in a 72-year-old woman. The neurofibroma had been on the skin of the left anterior shoulder for approximately 10 years. The presence of mast cells is well known in neurofibroma. However, infiltration of neurofibromas by eosinophils has not yet been documented. We propose that eosinophil infiltration is mediated by the effects of mast cells. We suggest that this is indirect evidence that mast cells in some neurofibromas are not quiescent but active. We also reintroduce the notion that acid-fast stains are a useful method to discriminate between mast cell granules and eosinophil granules. |
| doi_str_mv | 10.1097/DAD.0b013e318033275e |
| format | Article |
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The neurofibroma had been on the skin of the left anterior shoulder for approximately 10 years. The presence of mast cells is well known in neurofibroma. However, infiltration of neurofibromas by eosinophils has not yet been documented. We propose that eosinophil infiltration is mediated by the effects of mast cells. We suggest that this is indirect evidence that mast cells in some neurofibromas are not quiescent but active. We also reintroduce the notion that acid-fast stains are a useful method to discriminate between mast cell granules and eosinophil granules.</description><identifier>ISSN: 0193-1091</identifier><identifier>EISSN: 1533-0311</identifier><identifier>DOI: 10.1097/DAD.0b013e318033275e</identifier><identifier>PMID: 17414445</identifier><identifier>CODEN: AJODDB</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Aged ; Biological and medical sciences ; Coloring Agents ; Cytoplasmic Granules - pathology ; Dermatology ; Eosinophils - pathology ; Female ; Humans ; Mast Cells - pathology ; Medical sciences ; Neurofibroma - diagnosis ; Neurofibroma - pathology ; Shoulder ; Skin Neoplasms - diagnosis ; Skin Neoplasms - pathology ; Staining and Labeling - methods ; Tolonium Chloride</subject><ispartof>The American journal of dermatopathology, 2007-04, Vol.29 (2), p.187-189</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c335t-a69de016760495d1885bf75802827be88dbc6750dd5717cbea9616d39a07d6313</citedby><cites>FETCH-LOGICAL-c335t-a69de016760495d1885bf75802827be88dbc6750dd5717cbea9616d39a07d6313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18648715$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17414445$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hong, Seung Phil</creatorcontrib><creatorcontrib>Ahn, Sung Ku</creatorcontrib><title>Abundant eosinophil infiltration in a neurofibroma</title><title>The American journal of dermatopathology</title><addtitle>Am J Dermatopathol</addtitle><description>We report a case of sporadic cutaneous neurofibroma showing diffuse eosinophil infiltration in a 72-year-old woman. 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We also reintroduce the notion that acid-fast stains are a useful method to discriminate between mast cell granules and eosinophil granules.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Coloring Agents</subject><subject>Cytoplasmic Granules - pathology</subject><subject>Dermatology</subject><subject>Eosinophils - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Mast Cells - pathology</subject><subject>Medical sciences</subject><subject>Neurofibroma - diagnosis</subject><subject>Neurofibroma - pathology</subject><subject>Shoulder</subject><subject>Skin Neoplasms - diagnosis</subject><subject>Skin Neoplasms - pathology</subject><subject>Staining and Labeling - methods</subject><subject>Tolonium Chloride</subject><issn>0193-1091</issn><issn>1533-0311</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkM1KxDAYRYMozjj6BiLd6K7j9zW_XQ7jLwy40XVJmxQjbTIm7cK3tzKFAVeXC-fexSHkGmGNUMr7h83DGmpAaikqoLSQ3J6QJXJKc6CIp2QJWNJ8gnFBLlL6AsBCAT8nC5QMGWN8SYpNPXqj_ZDZkJwP-0_XZc63rhuiHlzwU8l05u0YQ-vqGHp9Sc5a3SV7NeeKfDw9vm9f8t3b8-t2s8sbSvmQa1EaCyikAFZyg0rxupVcQaEKWVulTN0IycEYLlE2tdWlQGFoqUEaQZGuyN3hdx_D92jTUPUuNbbrtLdhTJUEynlRsglkB7CJIaVo22ofXa_jT4VQ_bmqJlfVf1fT7Gb-H-vemuNoljMBtzOgU6O7NmrfuHTklGBKTr5_ASvjcPU</recordid><startdate>20070401</startdate><enddate>20070401</enddate><creator>Hong, Seung Phil</creator><creator>Ahn, Sung Ku</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070401</creationdate><title>Abundant eosinophil infiltration in a neurofibroma</title><author>Hong, Seung Phil ; Ahn, Sung Ku</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c335t-a69de016760495d1885bf75802827be88dbc6750dd5717cbea9616d39a07d6313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Coloring Agents</topic><topic>Cytoplasmic Granules - pathology</topic><topic>Dermatology</topic><topic>Eosinophils - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Mast Cells - pathology</topic><topic>Medical sciences</topic><topic>Neurofibroma - diagnosis</topic><topic>Neurofibroma - pathology</topic><topic>Shoulder</topic><topic>Skin Neoplasms - diagnosis</topic><topic>Skin Neoplasms - pathology</topic><topic>Staining and Labeling - methods</topic><topic>Tolonium Chloride</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hong, Seung Phil</creatorcontrib><creatorcontrib>Ahn, Sung Ku</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of dermatopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hong, Seung Phil</au><au>Ahn, Sung Ku</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Abundant eosinophil infiltration in a neurofibroma</atitle><jtitle>The American journal of dermatopathology</jtitle><addtitle>Am J Dermatopathol</addtitle><date>2007-04-01</date><risdate>2007</risdate><volume>29</volume><issue>2</issue><spage>187</spage><epage>189</epage><pages>187-189</pages><issn>0193-1091</issn><eissn>1533-0311</eissn><coden>AJODDB</coden><abstract>We report a case of sporadic cutaneous neurofibroma showing diffuse eosinophil infiltration in a 72-year-old woman. 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| fulltext | fulltext |
| identifier | ISSN: 0193-1091 |
| ispartof | The American journal of dermatopathology, 2007-04, Vol.29 (2), p.187-189 |
| issn | 0193-1091 1533-0311 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Aged Biological and medical sciences Coloring Agents Cytoplasmic Granules - pathology Dermatology Eosinophils - pathology Female Humans Mast Cells - pathology Medical sciences Neurofibroma - diagnosis Neurofibroma - pathology Shoulder Skin Neoplasms - diagnosis Skin Neoplasms - pathology Staining and Labeling - methods Tolonium Chloride |
| title | Abundant eosinophil infiltration in a neurofibroma |
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