Most pediatric patients with essential thrombocythemia show hypersensitivity to erythropoietin in vitro , with rare JAK2 V617F-positive erythroid colonies

Abstract Essential thrombocythemia (ET), a Philadelphia (Ph) chromosome negative chronic myeloproliferative disorder, is usually a disease of middle age and it is extremely rare in pediatric patients. In this report we studied 12 children diagnosed with ET and one child with thrombocytosis and famil...

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Veröffentlicht in:	Leukemia research 2008-03, Vol.32 (3), p.369-377
Hauptverfasser:	Veselovska, Jitka, Pospisilova, Dagmar, Pekova, Sona, Horvathova, Monika, Solna, Renata, Cmejlova, Jana, Cmejla, Radek, Belickova, Monika, Mihal, Vladimir, Stary, Jan, Divoky, Vladimir
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Child Childhood ET Clonality Clone Cells Epo hypersensitivity Erythroid Precursor Cells - drug effects Erythropoiesis Erythropoietin - blood Erythropoietin - pharmacology Female Genotype Hematology, Oncology and Palliative Medicine Hematopoietic Stem Cells Humans JAK2 V617F mutation Janus Kinase 2 - genetics Male Mutation Thrombocythemia, Essential - genetics Thrombocytosis - genetics
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