The effect of tryptophan administration on ileum contractility and oxidant status in mice
L-tryptophan (TRP) is the precursor amino acid for the synthesis of serotonin (5-HT). 5-HT is effective both on the food intake and gastrointestinal system contractility. The aim of this study was to search the effects of systemic TRP treatment on 5-HT levels of ileum and searching the effect of ile...
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| Veröffentlicht in: | Amino acids 2007-04, Vol.32 (3), p.453-458 |
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| description | L-tryptophan (TRP) is the precursor amino acid for the synthesis of serotonin (5-HT). 5-HT is effective both on the food intake and gastrointestinal system contractility. The aim of this study was to search the effects of systemic TRP treatment on 5-HT levels of ileum and searching the effect of ileal contractility and oxidant status. Swiss-albino mice were divided into two groups: 1. Control, 2. TRP-treated (100 mg/kg/24 h, i.p., for 7 days). Body weights were recorded at the beginning and at the end of experiments. Acetylcholine-induced contractile responses in the isolated ileum were recorded on polygraph. Ileal tissue malondialdehyde and glutathione levels determined by spectrophotometric and ileal tissue 5-HT levels were measured by immunohistochemical methods. TRP treatment decreased body weight and increased ileal contractile response. In the TRP-treated group, ileum malondialdehyde levels increased and glutathione levels decreased. Immunohistochemical detection showed that ileal 5-HT levels were increased by TRP treatment. There is a relationship between increased oxidative stress and increased contractility in the ileal tissue of the TRP-treated animals. These effects may be related to increased ileal 5-HT synthesis. |
| doi_str_mv | 10.1007/s00726-006-0339-5 |
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The aim of this study was to search the effects of systemic TRP treatment on 5-HT levels of ileum and searching the effect of ileal contractility and oxidant status. Swiss-albino mice were divided into two groups: 1. Control, 2. TRP-treated (100 mg/kg/24 h, i.p., for 7 days). Body weights were recorded at the beginning and at the end of experiments. Acetylcholine-induced contractile responses in the isolated ileum were recorded on polygraph. Ileal tissue malondialdehyde and glutathione levels determined by spectrophotometric and ileal tissue 5-HT levels were measured by immunohistochemical methods. TRP treatment decreased body weight and increased ileal contractile response. In the TRP-treated group, ileum malondialdehyde levels increased and glutathione levels decreased. Immunohistochemical detection showed that ileal 5-HT levels were increased by TRP treatment. There is a relationship between increased oxidative stress and increased contractility in the ileal tissue of the TRP-treated animals. These effects may be related to increased ileal 5-HT synthesis.</description><identifier>ISSN: 0939-4451</identifier><identifier>EISSN: 1438-2199</identifier><identifier>DOI: 10.1007/s00726-006-0339-5</identifier><identifier>PMID: 16729190</identifier><language>eng</language><publisher>Austria: Springer Nature B.V</publisher><subject>Acetylcholine - pharmacology ; Amino acids ; Animals ; Antidepressive Agents, Second-Generation - administration & dosage ; Body weight ; Cholinergic Agents - pharmacology ; Diet ; Eating - drug effects ; Glutathione - metabolism ; Ileum - metabolism ; Male ; Malondialdehyde ; Malondialdehyde - metabolism ; Mice ; Muscle Contraction - drug effects ; Organ Culture Techniques ; Oxidants ; Oxidative Stress - drug effects ; Oxidizing agents ; Rodents ; Searching ; Serotonin - biosynthesis ; Synthesis ; Tryptophan - administration & dosage</subject><ispartof>Amino acids, 2007-04, Vol.32 (3), p.453-458</ispartof><rights>Springer-Verlag 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-43d0cd895c4d3f3319fa31fca53c650486e4617b66e633d003fd7cdab810b4893</citedby><cites>FETCH-LOGICAL-c360t-43d0cd895c4d3f3319fa31fca53c650486e4617b66e633d003fd7cdab810b4893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16729190$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ozer, C</creatorcontrib><creatorcontrib>Gönül, B</creatorcontrib><creatorcontrib>Ercan, Z S</creatorcontrib><creatorcontrib>Take, G</creatorcontrib><creatorcontrib>Erdoğan, D</creatorcontrib><title>The effect of tryptophan administration on ileum contractility and oxidant status in mice</title><title>Amino acids</title><addtitle>Amino Acids</addtitle><description>L-tryptophan (TRP) is the precursor amino acid for the synthesis of serotonin (5-HT). 5-HT is effective both on the food intake and gastrointestinal system contractility. The aim of this study was to search the effects of systemic TRP treatment on 5-HT levels of ileum and searching the effect of ileal contractility and oxidant status. Swiss-albino mice were divided into two groups: 1. Control, 2. TRP-treated (100 mg/kg/24 h, i.p., for 7 days). Body weights were recorded at the beginning and at the end of experiments. Acetylcholine-induced contractile responses in the isolated ileum were recorded on polygraph. Ileal tissue malondialdehyde and glutathione levels determined by spectrophotometric and ileal tissue 5-HT levels were measured by immunohistochemical methods. TRP treatment decreased body weight and increased ileal contractile response. In the TRP-treated group, ileum malondialdehyde levels increased and glutathione levels decreased. Immunohistochemical detection showed that ileal 5-HT levels were increased by TRP treatment. There is a relationship between increased oxidative stress and increased contractility in the ileal tissue of the TRP-treated animals. These effects may be related to increased ileal 5-HT synthesis.</description><subject>Acetylcholine - pharmacology</subject><subject>Amino acids</subject><subject>Animals</subject><subject>Antidepressive Agents, Second-Generation - administration & dosage</subject><subject>Body weight</subject><subject>Cholinergic Agents - pharmacology</subject><subject>Diet</subject><subject>Eating - drug effects</subject><subject>Glutathione - metabolism</subject><subject>Ileum - metabolism</subject><subject>Male</subject><subject>Malondialdehyde</subject><subject>Malondialdehyde - metabolism</subject><subject>Mice</subject><subject>Muscle Contraction - drug effects</subject><subject>Organ Culture Techniques</subject><subject>Oxidants</subject><subject>Oxidative Stress - drug effects</subject><subject>Oxidizing agents</subject><subject>Rodents</subject><subject>Searching</subject><subject>Serotonin - biosynthesis</subject><subject>Synthesis</subject><subject>Tryptophan - administration & dosage</subject><issn>0939-4451</issn><issn>1438-2199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kctKxDAUhoMoOo4-gBsJCOKmetK0abKUwRsIbnThKmRywUibjE0KztubYQYEF0IucPjOgfN_CJ0RuCYA3U0qT80qgHIpFVW7h2akobyqiRD7aAaiFJumJUfoOKVPAFJzwg7REWFdLYiAGXp__bDYOmd1xtHhPK5XOa4-VMDKDD74lEeVfQy4HN_bacA6hlLT2fc-r7EKBsdvb1TIOGWVp4R9wIPX9gQdONUne7r75-jt_u518Vg9vzw8LW6fK00Z5KqhBrThotWNoY5SIpyixGnVUs1aaDizDSPdkjHLaGGBOtNpo5acwLLhgs7R5Xbuaoxfk01ZDj5p2_cq2Dgl2QFtqeBQwKt_wRJKCU_UJco5uviDfsZpDGUNSUC0rAMueKHIltJjTGm0Tq5GP6hxXSC5ESS3gmQRJDeCZFt6zneTp-VgzW_Hzgj9ASSCiv4</recordid><startdate>20070401</startdate><enddate>20070401</enddate><creator>Ozer, C</creator><creator>Gönül, B</creator><creator>Ercan, Z S</creator><creator>Take, G</creator><creator>Erdoğan, D</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>20070401</creationdate><title>The effect of tryptophan administration on ileum contractility and oxidant status in mice</title><author>Ozer, C ; Gönül, B ; Ercan, Z S ; Take, G ; Erdoğan, D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-43d0cd895c4d3f3319fa31fca53c650486e4617b66e633d003fd7cdab810b4893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Acetylcholine - pharmacology</topic><topic>Amino acids</topic><topic>Animals</topic><topic>Antidepressive Agents, Second-Generation - administration & dosage</topic><topic>Body weight</topic><topic>Cholinergic Agents - pharmacology</topic><topic>Diet</topic><topic>Eating - drug effects</topic><topic>Glutathione - metabolism</topic><topic>Ileum - metabolism</topic><topic>Male</topic><topic>Malondialdehyde</topic><topic>Malondialdehyde - metabolism</topic><topic>Mice</topic><topic>Muscle Contraction - drug effects</topic><topic>Organ Culture Techniques</topic><topic>Oxidants</topic><topic>Oxidative Stress - drug effects</topic><topic>Oxidizing agents</topic><topic>Rodents</topic><topic>Searching</topic><topic>Serotonin - biosynthesis</topic><topic>Synthesis</topic><topic>Tryptophan - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ozer, C</creatorcontrib><creatorcontrib>Gönül, B</creatorcontrib><creatorcontrib>Ercan, Z S</creatorcontrib><creatorcontrib>Take, G</creatorcontrib><creatorcontrib>Erdoğan, D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Amino acids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ozer, C</au><au>Gönül, B</au><au>Ercan, Z S</au><au>Take, G</au><au>Erdoğan, D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of tryptophan administration on ileum contractility and oxidant status in mice</atitle><jtitle>Amino acids</jtitle><addtitle>Amino Acids</addtitle><date>2007-04-01</date><risdate>2007</risdate><volume>32</volume><issue>3</issue><spage>453</spage><epage>458</epage><pages>453-458</pages><issn>0939-4451</issn><eissn>1438-2199</eissn><abstract>L-tryptophan (TRP) is the precursor amino acid for the synthesis of serotonin (5-HT). 5-HT is effective both on the food intake and gastrointestinal system contractility. The aim of this study was to search the effects of systemic TRP treatment on 5-HT levels of ileum and searching the effect of ileal contractility and oxidant status. Swiss-albino mice were divided into two groups: 1. Control, 2. TRP-treated (100 mg/kg/24 h, i.p., for 7 days). Body weights were recorded at the beginning and at the end of experiments. Acetylcholine-induced contractile responses in the isolated ileum were recorded on polygraph. Ileal tissue malondialdehyde and glutathione levels determined by spectrophotometric and ileal tissue 5-HT levels were measured by immunohistochemical methods. TRP treatment decreased body weight and increased ileal contractile response. In the TRP-treated group, ileum malondialdehyde levels increased and glutathione levels decreased. Immunohistochemical detection showed that ileal 5-HT levels were increased by TRP treatment. There is a relationship between increased oxidative stress and increased contractility in the ileal tissue of the TRP-treated animals. These effects may be related to increased ileal 5-HT synthesis.</abstract><cop>Austria</cop><pub>Springer Nature B.V</pub><pmid>16729190</pmid><doi>10.1007/s00726-006-0339-5</doi><tpages>6</tpages></addata></record> |
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| subjects | Acetylcholine - pharmacology Amino acids Animals Antidepressive Agents, Second-Generation - administration & dosage Body weight Cholinergic Agents - pharmacology Diet Eating - drug effects Glutathione - metabolism Ileum - metabolism Male Malondialdehyde Malondialdehyde - metabolism Mice Muscle Contraction - drug effects Organ Culture Techniques Oxidants Oxidative Stress - drug effects Oxidizing agents Rodents Searching Serotonin - biosynthesis Synthesis Tryptophan - administration & dosage |
| title | The effect of tryptophan administration on ileum contractility and oxidant status in mice |
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