Membrane Proteins of the Endoplasmic Reticulum Induce High-Curvature Tubules

The tubular structure of the endoplasmic reticulum (ER) appears to be generated by integral membrane proteins, the reticulons and a protein family consisting of DP1 in mammals and Yop1p in yeast. Here, individual members of these families were found to be sufficient to generate membrane tubules. Whe...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2008-02, Vol.319 (5867), p.1247-1250
Hauptverfasser:	Hu, Junjie, Shibata, Yoko, Voss, Christiane, Shemesh, Tom, Li, Zongli, Coughlin, Margaret, Kozlov, Michael M, Rapoport, Tom A, Prinz, William A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Animals Biological and medical sciences Biopolymers - chemistry Biopolymers - metabolism Cell membranes Cell structures and functions Cellular biology Cercopithecus aethiops COS Cells Curvature Detergents Endoplasmic Reticulum - chemistry Endoplasmic Reticulum - metabolism Endoplasmic Reticulum - ultrastructure Fundamental and applied biological sciences. Psychology Hydrophobic and Hydrophilic Interactions Intracellular Membranes - chemistry Intracellular Membranes - ultrastructure Lipid Bilayers Lipids Membrane Lipids - chemistry Membrane proteins Membrane Proteins - chemistry Membrane Proteins - metabolism Membrane Transport Proteins - chemistry Membrane Transport Proteins - metabolism Membranes Microscopy, Electron Miscellaneous Models, Biological Molecular and cellular biology Molecular Sequence Data Mutant Proteins - chemistry Mutant Proteins - metabolism Protein Structure, Quaternary Protein Structure, Tertiary Proteins Proteolipids - chemistry Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Yeasts
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