Stimulatory Activity of Lignans from Machilus thunbergii on Osteoblast Differentiation
Phytoestrogens are naturally occurring compounds exerting estrogenic activity, and include isoflavonoids, flavonoids and lignans. In the present study, we evaluated the stimulating activity of six lignans, meso-dihydroguaiaretic acid, nordihydroguaiaretic acid, machilin A, guaiacin, isoguaiacin and...
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| Veröffentlicht in: | Biological & Pharmaceutical Bulletin 2007, Vol.30(4), pp.814-817 |
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| description | Phytoestrogens are naturally occurring compounds exerting estrogenic activity, and include isoflavonoids, flavonoids and lignans. In the present study, we evaluated the stimulating activity of six lignans, meso-dihydroguaiaretic acid, nordihydroguaiaretic acid, machilin A, guaiacin, isoguaiacin and isoguaiacin dimethylether, from Machilus thunbergii, on osteoblast differentiation employing primary cultures of mouse osteoblast as an in vitro assay system. Among the six lignans tested, arylnaphthalene type lignans such as guaiacin, isoguaiacin and isoguaiacin dimethylether significantly increased alkaline phosphatase activity, whereas bibenzylbutane type lignans such as meso-dihydroguaiaretic acid, nordihydroguaiaretic acid and machilin A showed little effects. Isoguaiacin and isoguaiacin dimethylether also increased collagen synthesis as well as calcium deposition. In addition, treatment of the mouse osteoblasts with tamoxifen markedly reduced ALP activity increased by isoguaiacin or isoguaiacin dimethylether, suggesting the involvement of estrogen receptor in the action of these lignans on osteoblast differentiation. Taken together, these results suggest that arylnaphthalene type lignans such as guaiacin, isoguaiacin and isoguaiacin dimethylether significantly increase osteoblast differentiation. |
| doi_str_mv | 10.1248/bpb.30.814 |
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In the present study, we evaluated the stimulating activity of six lignans, meso-dihydroguaiaretic acid, nordihydroguaiaretic acid, machilin A, guaiacin, isoguaiacin and isoguaiacin dimethylether, from Machilus thunbergii, on osteoblast differentiation employing primary cultures of mouse osteoblast as an in vitro assay system. Among the six lignans tested, arylnaphthalene type lignans such as guaiacin, isoguaiacin and isoguaiacin dimethylether significantly increased alkaline phosphatase activity, whereas bibenzylbutane type lignans such as meso-dihydroguaiaretic acid, nordihydroguaiaretic acid and machilin A showed little effects. Isoguaiacin and isoguaiacin dimethylether also increased collagen synthesis as well as calcium deposition. In addition, treatment of the mouse osteoblasts with tamoxifen markedly reduced ALP activity increased by isoguaiacin or isoguaiacin dimethylether, suggesting the involvement of estrogen receptor in the action of these lignans on osteoblast differentiation. Taken together, these results suggest that arylnaphthalene type lignans such as guaiacin, isoguaiacin and isoguaiacin dimethylether significantly increase osteoblast differentiation.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.30.814</identifier><identifier>PMID: 17409528</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Alkaline Phosphatase - analysis ; Alkaline Phosphatase - metabolism ; Animals ; Animals, Newborn ; Calcinosis - metabolism ; Cell Differentiation - drug effects ; Cells, Cultured ; Collagen - analysis ; Collagen - biosynthesis ; Dose-Response Relationship, Drug ; estrogen receptor ; Histocytochemistry ; isoguaiacin dimethylether ; Lauraceae - chemistry ; lignans ; Lignans - chemistry ; Lignans - isolation & purification ; Lignans - pharmacology ; Machilus thunbergii ; Mice ; Mice, Inbred ICR ; Molecular Structure ; osteoblast differentiation ; Osteoblasts - cytology ; Osteoblasts - drug effects ; Osteoblasts - enzymology ; Osteoblasts - metabolism ; Skull - cytology</subject><ispartof>Biological and Pharmaceutical Bulletin, 2007, Vol.30(4), pp.814-817</ispartof><rights>2007 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c684t-32c5a941b6097f8208278fb58491c31294637f99b3a2592e9fb29c38a470c2c43</citedby><cites>FETCH-LOGICAL-c684t-32c5a941b6097f8208278fb58491c31294637f99b3a2592e9fb29c38a470c2c43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17409528$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Mi Kyeong</creatorcontrib><creatorcontrib>Yang, Hyekyung</creatorcontrib><creatorcontrib>Ma, Choong Je</creatorcontrib><creatorcontrib>Kim, Young Choong</creatorcontrib><creatorcontrib>College of Pharmacy and Research Institute of Pharmaceutical Science</creatorcontrib><creatorcontrib>Seoul National University</creatorcontrib><title>Stimulatory Activity of Lignans from Machilus thunbergii on Osteoblast Differentiation</title><title>Biological & Pharmaceutical Bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>Phytoestrogens are naturally occurring compounds exerting estrogenic activity, and include isoflavonoids, flavonoids and lignans. In the present study, we evaluated the stimulating activity of six lignans, meso-dihydroguaiaretic acid, nordihydroguaiaretic acid, machilin A, guaiacin, isoguaiacin and isoguaiacin dimethylether, from Machilus thunbergii, on osteoblast differentiation employing primary cultures of mouse osteoblast as an in vitro assay system. Among the six lignans tested, arylnaphthalene type lignans such as guaiacin, isoguaiacin and isoguaiacin dimethylether significantly increased alkaline phosphatase activity, whereas bibenzylbutane type lignans such as meso-dihydroguaiaretic acid, nordihydroguaiaretic acid and machilin A showed little effects. Isoguaiacin and isoguaiacin dimethylether also increased collagen synthesis as well as calcium deposition. In addition, treatment of the mouse osteoblasts with tamoxifen markedly reduced ALP activity increased by isoguaiacin or isoguaiacin dimethylether, suggesting the involvement of estrogen receptor in the action of these lignans on osteoblast differentiation. Taken together, these results suggest that arylnaphthalene type lignans such as guaiacin, isoguaiacin and isoguaiacin dimethylether significantly increase osteoblast differentiation.</description><subject>Alkaline Phosphatase - analysis</subject><subject>Alkaline Phosphatase - metabolism</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Calcinosis - metabolism</subject><subject>Cell Differentiation - drug effects</subject><subject>Cells, Cultured</subject><subject>Collagen - analysis</subject><subject>Collagen - biosynthesis</subject><subject>Dose-Response Relationship, Drug</subject><subject>estrogen receptor</subject><subject>Histocytochemistry</subject><subject>isoguaiacin dimethylether</subject><subject>Lauraceae - chemistry</subject><subject>lignans</subject><subject>Lignans - chemistry</subject><subject>Lignans - isolation & purification</subject><subject>Lignans - pharmacology</subject><subject>Machilus thunbergii</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Molecular Structure</subject><subject>osteoblast differentiation</subject><subject>Osteoblasts - cytology</subject><subject>Osteoblasts - drug effects</subject><subject>Osteoblasts - enzymology</subject><subject>Osteoblasts - metabolism</subject><subject>Skull - cytology</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU2LFDEQhoMo7uzqxR8gDYIHocfKVyc5ybK6qzCyBz-uIR3TMxm6kzFJC_PvzdCzLnipHOrJU8VbCL3CsMaEyff9oV9TWEvMnqAVpky0nGD-FK1AYdl2mMsLdJnzHgAEEPocXWDBQHEiV-jnt-KneTQlpmNzbYv_48uxiUOz8dtgQm6GFKfmq7E7P865Kbs59C5tvW9iaO5zcbEfTS7NRz8MLrlQvCk-hhfo2WDG7F6e3yv04_bT95vP7eb-7svN9aa1nWSlpcRyoxjuO1BikAQkEXLouWQKW4qJYh0Vg1I9NYQr4tTQE2WpNEyAJZbRK_R28R5S_D27XPTks3XjaIKLc9YCKCeK8gq--Q_cxzmFupvGjCnaASWiUu8WyqaYc3KDPiQ_mXTUGPQpa12z1hR0zbrCr8_KuZ_cr0f0HG4Fbhegdr01YwyjD-5xsM2i93GMmtTDaAAKwDRQpaHqT0UQzjt1En1YRPtczNb9m2RS8XZ0D0uxpZw-P3TsziTtAv0L2jKl5Q</recordid><startdate>20070401</startdate><enddate>20070401</enddate><creator>Lee, Mi Kyeong</creator><creator>Yang, Hyekyung</creator><creator>Ma, Choong Je</creator><creator>Kim, Young Choong</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20070401</creationdate><title>Stimulatory Activity of Lignans from Machilus thunbergii on Osteoblast Differentiation</title><author>Lee, Mi Kyeong ; Yang, Hyekyung ; Ma, Choong Je ; Kim, Young Choong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c684t-32c5a941b6097f8208278fb58491c31294637f99b3a2592e9fb29c38a470c2c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Alkaline Phosphatase - analysis</topic><topic>Alkaline Phosphatase - metabolism</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Calcinosis - metabolism</topic><topic>Cell Differentiation - drug effects</topic><topic>Cells, Cultured</topic><topic>Collagen - analysis</topic><topic>Collagen - biosynthesis</topic><topic>Dose-Response Relationship, Drug</topic><topic>estrogen receptor</topic><topic>Histocytochemistry</topic><topic>isoguaiacin dimethylether</topic><topic>Lauraceae - chemistry</topic><topic>lignans</topic><topic>Lignans - chemistry</topic><topic>Lignans - isolation & purification</topic><topic>Lignans - pharmacology</topic><topic>Machilus thunbergii</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Molecular Structure</topic><topic>osteoblast differentiation</topic><topic>Osteoblasts - cytology</topic><topic>Osteoblasts - drug effects</topic><topic>Osteoblasts - enzymology</topic><topic>Osteoblasts - metabolism</topic><topic>Skull - cytology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Mi Kyeong</creatorcontrib><creatorcontrib>Yang, Hyekyung</creatorcontrib><creatorcontrib>Ma, Choong Je</creatorcontrib><creatorcontrib>Kim, Young Choong</creatorcontrib><creatorcontrib>College of Pharmacy and Research Institute of Pharmaceutical Science</creatorcontrib><creatorcontrib>Seoul National University</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & Pharmaceutical Bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Mi Kyeong</au><au>Yang, Hyekyung</au><au>Ma, Choong Je</au><au>Kim, Young Choong</au><aucorp>College of Pharmacy and Research Institute of Pharmaceutical Science</aucorp><aucorp>Seoul National University</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stimulatory Activity of Lignans from Machilus thunbergii on Osteoblast Differentiation</atitle><jtitle>Biological & Pharmaceutical Bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>2007-04-01</date><risdate>2007</risdate><volume>30</volume><issue>4</issue><spage>814</spage><epage>817</epage><pages>814-817</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>Phytoestrogens are naturally occurring compounds exerting estrogenic activity, and include isoflavonoids, flavonoids and lignans. In the present study, we evaluated the stimulating activity of six lignans, meso-dihydroguaiaretic acid, nordihydroguaiaretic acid, machilin A, guaiacin, isoguaiacin and isoguaiacin dimethylether, from Machilus thunbergii, on osteoblast differentiation employing primary cultures of mouse osteoblast as an in vitro assay system. Among the six lignans tested, arylnaphthalene type lignans such as guaiacin, isoguaiacin and isoguaiacin dimethylether significantly increased alkaline phosphatase activity, whereas bibenzylbutane type lignans such as meso-dihydroguaiaretic acid, nordihydroguaiaretic acid and machilin A showed little effects. Isoguaiacin and isoguaiacin dimethylether also increased collagen synthesis as well as calcium deposition. In addition, treatment of the mouse osteoblasts with tamoxifen markedly reduced ALP activity increased by isoguaiacin or isoguaiacin dimethylether, suggesting the involvement of estrogen receptor in the action of these lignans on osteoblast differentiation. Taken together, these results suggest that arylnaphthalene type lignans such as guaiacin, isoguaiacin and isoguaiacin dimethylether significantly increase osteoblast differentiation.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>17409528</pmid><doi>10.1248/bpb.30.814</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Alkaline Phosphatase - analysis Alkaline Phosphatase - metabolism Animals Animals, Newborn Calcinosis - metabolism Cell Differentiation - drug effects Cells, Cultured Collagen - analysis Collagen - biosynthesis Dose-Response Relationship, Drug estrogen receptor Histocytochemistry isoguaiacin dimethylether Lauraceae - chemistry lignans Lignans - chemistry Lignans - isolation & purification Lignans - pharmacology Machilus thunbergii Mice Mice, Inbred ICR Molecular Structure osteoblast differentiation Osteoblasts - cytology Osteoblasts - drug effects Osteoblasts - enzymology Osteoblasts - metabolism Skull - cytology |
| title | Stimulatory Activity of Lignans from Machilus thunbergii on Osteoblast Differentiation |
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