Genetic diversity and function in the human cytosolic sulfotransferases

Amino-acid substitutions, which result from common nonsynonymous (NS) polymorphisms, may dramatically alter the function of the encoded protein. Gaining insight into how these substitutions alter function is a step toward acquiring predictability. In this study, we incorporated gene resequencing, fu...

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Veröffentlicht in:	The pharmacogenomics journal 2007-04, Vol.7 (2), p.133-143
Hauptverfasser:	Hildebrandt, M A T, Carrington, D P, Thomae, B A, Eckloff, B W, Schaid, D J, Yee, V C, Weinshilboum, R M, Wieben, E D
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid sequence Amino Acid Substitution Animals Biological diversity Biomedical and Life Sciences Biomedicine Cercopithecus aethiops Computer Simulation COS Cells Crystal structure Crystallography - methods Cytosol - enzymology Databases, Protein Deoxyribonucleic acid DNA Enzyme kinetics Evaluation Evolution, Molecular Evolutionary conservation Gene Expression Gene Frequency Genetic diversity Genetic research Genetic Variation Genomics Human Genetics Human genome Humans Isoenzymes Isoenzymes - genetics Isoenzymes - metabolism Models, Molecular Oncology original-article Pharmacotherapy Physicochemical properties Polymorphism, Single Nucleotide Protein Conformation Protein structure Proteins Psychopharmacology Selection, Genetic Sequence Analysis, DNA Sequence Analysis, Protein Single nucleotide polymorphisms Single-nucleotide polymorphism Sulfotransferases - chemistry Sulfotransferases - genetics Sulfotransferases - metabolism Transfection
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