Coordinate Expression and Functional Profiling Identify an Extracellular Proteolytic Signaling Pathway

A multidisciplinary method combining transcriptional data, specificity profiling, and biological characterization of an enzyme may be used to predict novel substrates. By integrating protease substrate profiling with microarray gene coexpression data from nearly 2,000 human normal and cancerous tiss...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2007-04, Vol.104 (14), p.5771-5776
Hauptverfasser:	Bhatt, Ami S., Welm, Alana, Farady, Christopher J., Vásquez, Maximiliano, Wilson, Keith, Craik, Charles S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Biochemistry Biological Sciences Bone marrow Bone Marrow Cells - cytology Cancer Cell Line, Tumor Cells, Cultured Cultured cells Female Gene expression Gene Expression Profiling Humans Macrophage Activation Macrophages Macrophages, Peritoneal - cytology Macrophages, Peritoneal - enzymology Macrophages, Peritoneal - metabolism Male Mice Nitric oxide Nitric Oxide - antagonists & inhibitors Oligonucleotide Array Sequence Analysis Oxides Peritoneal macrophages Proteases Proteinase Inhibitory Proteins, Secretory - genetics Proteinase Inhibitory Proteins, Secretory - metabolism Proteomics Recombinant Proteins - metabolism Serine Endopeptidases - genetics Serine Endopeptidases - metabolism Signal Transduction Substrate Specificity Tissue samples Transcription, Genetic Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!