Effects of folic acid fortification in the rates of malformations at birth in Chile
The effects of folic acid fortification on neural tube defects is well known. Other reports show a beneficial effect of the fortification on orofacial clefts, urinary malformations and defects caused by limb reduction. To determine the changes in prevalence of congenital malformations after the star...
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| Veröffentlicht in: | Revista medíca de Chile 2007-02, Vol.135 (2), p.198-204 |
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| container_title | Revista medíca de Chile |
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| creator | Nazer H, Julio Cifuentes O, Lucía Aguila R, Alfredo Juárez H, María Eugenia Cid R, María Pía Godoy V, María Loreto García A, Karen Melibosky R, Francisco |
| description | The effects of folic acid fortification on neural tube defects is well known. Other reports show a beneficial effect of the fortification on orofacial clefts, urinary malformations and defects caused by limb reduction.
To determine the changes in prevalence of congenital malformations after the start of flour folic acid fortification in Chile.
The rates of 22 malformations occurring in the maternity of the University of Chile Clinical Hospital and other Chilean hospitals participating in the Latin American Collaborative Study of Congenital Malformations (ECLAMC) were compared before and after the start of flour folic acid fortification.
After the start of folic acid fortification a significant reduction in the rates of anencephalia, spina bifida and diaphragmatic hernia, was observed. The rates of all other malformations remained stable or increased. The rates of all malformations at the University of Chile Clinical Hospital had a steady increase until 2005 and were significantly higher than in the rest of hospitals participating in ECLAMC.
Folic acid fortification was associated with an expected reduction in rates of spina bifida and anencephalia and an unexpected reduction in the rates of diaphragmatic hernia. |
| format | Article |
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To determine the changes in prevalence of congenital malformations after the start of flour folic acid fortification in Chile.
The rates of 22 malformations occurring in the maternity of the University of Chile Clinical Hospital and other Chilean hospitals participating in the Latin American Collaborative Study of Congenital Malformations (ECLAMC) were compared before and after the start of flour folic acid fortification.
After the start of folic acid fortification a significant reduction in the rates of anencephalia, spina bifida and diaphragmatic hernia, was observed. The rates of all other malformations remained stable or increased. The rates of all malformations at the University of Chile Clinical Hospital had a steady increase until 2005 and were significantly higher than in the rest of hospitals participating in ECLAMC.
Folic acid fortification was associated with an expected reduction in rates of spina bifida and anencephalia and an unexpected reduction in the rates of diaphragmatic hernia.</description><identifier>ISSN: 0034-9887</identifier><identifier>PMID: 17406737</identifier><language>eng ; spa</language><publisher>Chile</publisher><subject>Anencephaly - epidemiology ; Anencephaly - prevention & control ; Chi-Square Distribution ; Chile - epidemiology ; Congenital Abnormalities - epidemiology ; Congenital Abnormalities - prevention & control ; Dietary Supplements ; Flour ; Folic Acid - administration & dosage ; Food, Fortified ; Hernia, Diaphragmatic - epidemiology ; Hernia, Diaphragmatic - prevention & control ; Humans ; Infant, Newborn ; Live Birth - epidemiology ; Prevalence ; Spinal Dysraphism - epidemiology ; Spinal Dysraphism - prevention & control ; Stillbirth - epidemiology</subject><ispartof>Revista medíca de Chile, 2007-02, Vol.135 (2), p.198-204</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17406737$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nazer H, Julio</creatorcontrib><creatorcontrib>Cifuentes O, Lucía</creatorcontrib><creatorcontrib>Aguila R, Alfredo</creatorcontrib><creatorcontrib>Juárez H, María Eugenia</creatorcontrib><creatorcontrib>Cid R, María Pía</creatorcontrib><creatorcontrib>Godoy V, María Loreto</creatorcontrib><creatorcontrib>García A, Karen</creatorcontrib><creatorcontrib>Melibosky R, Francisco</creatorcontrib><title>Effects of folic acid fortification in the rates of malformations at birth in Chile</title><title>Revista medíca de Chile</title><addtitle>Rev Med Chil</addtitle><description>The effects of folic acid fortification on neural tube defects is well known. Other reports show a beneficial effect of the fortification on orofacial clefts, urinary malformations and defects caused by limb reduction.
To determine the changes in prevalence of congenital malformations after the start of flour folic acid fortification in Chile.
The rates of 22 malformations occurring in the maternity of the University of Chile Clinical Hospital and other Chilean hospitals participating in the Latin American Collaborative Study of Congenital Malformations (ECLAMC) were compared before and after the start of flour folic acid fortification.
After the start of folic acid fortification a significant reduction in the rates of anencephalia, spina bifida and diaphragmatic hernia, was observed. The rates of all other malformations remained stable or increased. The rates of all malformations at the University of Chile Clinical Hospital had a steady increase until 2005 and were significantly higher than in the rest of hospitals participating in ECLAMC.
Folic acid fortification was associated with an expected reduction in rates of spina bifida and anencephalia and an unexpected reduction in the rates of diaphragmatic hernia.</description><subject>Anencephaly - epidemiology</subject><subject>Anencephaly - prevention & control</subject><subject>Chi-Square Distribution</subject><subject>Chile - epidemiology</subject><subject>Congenital Abnormalities - epidemiology</subject><subject>Congenital Abnormalities - prevention & control</subject><subject>Dietary Supplements</subject><subject>Flour</subject><subject>Folic Acid - administration & dosage</subject><subject>Food, Fortified</subject><subject>Hernia, Diaphragmatic - epidemiology</subject><subject>Hernia, Diaphragmatic - prevention & control</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Live Birth - epidemiology</subject><subject>Prevalence</subject><subject>Spinal Dysraphism - epidemiology</subject><subject>Spinal Dysraphism - prevention & control</subject><subject>Stillbirth - epidemiology</subject><issn>0034-9887</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo10DtPxDAMB_AMIO44-AooE1slp2mbZESn4yGdxADMlZuHGpQ-SNKBb085jsm2_j978AXZAvCqUFKKDblO6ROgFA2TV2TDRAWN4GJL3g7OWZ0TnRx1U_CaovZmbWP2zmvMfhqpH2nuLY2Y7QkOGFYwnMJEMdPOx9z_sn3vg70hlw5DsrfnuiMfj4f3_XNxfH162T8ci5lxlQvWaMW0AbVODjtEoYSqhKpBlMqAKQWDEpXumOSN5VBLLkuDtpK1BOeQ78j93905Tl-LTbkdfNI2BBzttKRWAK_XLbHCuzNcusGado5-wPjd_r-B_wBMzFdf</recordid><startdate>200702</startdate><enddate>200702</enddate><creator>Nazer H, Julio</creator><creator>Cifuentes O, Lucía</creator><creator>Aguila R, Alfredo</creator><creator>Juárez H, María Eugenia</creator><creator>Cid R, María Pía</creator><creator>Godoy V, María Loreto</creator><creator>García A, Karen</creator><creator>Melibosky R, Francisco</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200702</creationdate><title>Effects of folic acid fortification in the rates of malformations at birth in Chile</title><author>Nazer H, Julio ; Cifuentes O, Lucía ; Aguila R, Alfredo ; Juárez H, María Eugenia ; Cid R, María Pía ; Godoy V, María Loreto ; García A, Karen ; Melibosky R, Francisco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p139t-16c91cd09139fabaa797947950729d0d27102a9cb1836e3058382dae48580ffa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; spa</language><creationdate>2007</creationdate><topic>Anencephaly - epidemiology</topic><topic>Anencephaly - prevention & control</topic><topic>Chi-Square Distribution</topic><topic>Chile - epidemiology</topic><topic>Congenital Abnormalities - epidemiology</topic><topic>Congenital Abnormalities - prevention & control</topic><topic>Dietary Supplements</topic><topic>Flour</topic><topic>Folic Acid - administration & dosage</topic><topic>Food, Fortified</topic><topic>Hernia, Diaphragmatic - epidemiology</topic><topic>Hernia, Diaphragmatic - prevention & control</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Live Birth - epidemiology</topic><topic>Prevalence</topic><topic>Spinal Dysraphism - epidemiology</topic><topic>Spinal Dysraphism - prevention & control</topic><topic>Stillbirth - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nazer H, Julio</creatorcontrib><creatorcontrib>Cifuentes O, Lucía</creatorcontrib><creatorcontrib>Aguila R, Alfredo</creatorcontrib><creatorcontrib>Juárez H, María Eugenia</creatorcontrib><creatorcontrib>Cid R, María Pía</creatorcontrib><creatorcontrib>Godoy V, María Loreto</creatorcontrib><creatorcontrib>García A, Karen</creatorcontrib><creatorcontrib>Melibosky R, Francisco</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Revista medíca de Chile</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nazer H, Julio</au><au>Cifuentes O, Lucía</au><au>Aguila R, Alfredo</au><au>Juárez H, María Eugenia</au><au>Cid R, María Pía</au><au>Godoy V, María Loreto</au><au>García A, Karen</au><au>Melibosky R, Francisco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of folic acid fortification in the rates of malformations at birth in Chile</atitle><jtitle>Revista medíca de Chile</jtitle><addtitle>Rev Med Chil</addtitle><date>2007-02</date><risdate>2007</risdate><volume>135</volume><issue>2</issue><spage>198</spage><epage>204</epage><pages>198-204</pages><issn>0034-9887</issn><abstract>The effects of folic acid fortification on neural tube defects is well known. Other reports show a beneficial effect of the fortification on orofacial clefts, urinary malformations and defects caused by limb reduction.
To determine the changes in prevalence of congenital malformations after the start of flour folic acid fortification in Chile.
The rates of 22 malformations occurring in the maternity of the University of Chile Clinical Hospital and other Chilean hospitals participating in the Latin American Collaborative Study of Congenital Malformations (ECLAMC) were compared before and after the start of flour folic acid fortification.
After the start of folic acid fortification a significant reduction in the rates of anencephalia, spina bifida and diaphragmatic hernia, was observed. The rates of all other malformations remained stable or increased. The rates of all malformations at the University of Chile Clinical Hospital had a steady increase until 2005 and were significantly higher than in the rest of hospitals participating in ECLAMC.
Folic acid fortification was associated with an expected reduction in rates of spina bifida and anencephalia and an unexpected reduction in the rates of diaphragmatic hernia.</abstract><cop>Chile</cop><pmid>17406737</pmid><tpages>7</tpages></addata></record> |
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| ispartof | Revista medíca de Chile, 2007-02, Vol.135 (2), p.198-204 |
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| language | eng ; spa |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Anencephaly - epidemiology Anencephaly - prevention & control Chi-Square Distribution Chile - epidemiology Congenital Abnormalities - epidemiology Congenital Abnormalities - prevention & control Dietary Supplements Flour Folic Acid - administration & dosage Food, Fortified Hernia, Diaphragmatic - epidemiology Hernia, Diaphragmatic - prevention & control Humans Infant, Newborn Live Birth - epidemiology Prevalence Spinal Dysraphism - epidemiology Spinal Dysraphism - prevention & control Stillbirth - epidemiology |
| title | Effects of folic acid fortification in the rates of malformations at birth in Chile |
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