The contribution of cerebral vascular semicarbazide-sensitive amine oxidase to cerebral amyloid angiopathy in Alzheimer's disease

Semicarbazide‐sensitive amine oxidase (SSAO) catalyses the oxidative deamination of a variety of endogenous substrates, such as methylamine and aminoacetone, to produce highly reactive aldehydes, which are capable of inducing protein cross‐linkage, beta amyloid (Aβ) aggregation and advanced glycatio...

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Veröffentlicht in:	Neuropathology and applied neurobiology 2008-04, Vol.34 (2), p.194-204
Hauptverfasser:	Jiang, Z. J., Richardson, J. S., Yu, P. H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - enzymology Alzheimer's disease Amine Oxidase (Copper-Containing) - metabolism Amyloid beta-Peptides - metabolism Biological and medical sciences Blood Vessels - enzymology Brain - blood supply Brain - metabolism Brain - pathology cerebral amyloid angiopathy Cerebral Amyloid Angiopathy - enzymology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female formaldehyde Humans Immunohistochemistry Male Medical sciences Neurology semicarbazide-sensitive amine oxidase Umbilical Cord
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