A Practical, Metal-Free Synthesis of 1H-Indazoles
The synthesis of 1H-indazoles is achieved from o-aminobenzoximes by the selective activation of the oxime in the presence of the amino group. The reaction occurs with a variety of substituted o-aminobenzoximes using a slight excess of methanesulfonyl chloride and triethylamine at 0−23 °C and is amen...
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| Veröffentlicht in: | Organic letters 2008-03, Vol.10 (5), p.1021-1023 |
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| container_end_page | 1023 |
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| container_issue | 5 |
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| container_title | Organic letters |
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| creator | Counceller, Carla M Eichman, Chad C Wray, Brenda C Stambuli, James P |
| description | The synthesis of 1H-indazoles is achieved from o-aminobenzoximes by the selective activation of the oxime in the presence of the amino group. The reaction occurs with a variety of substituted o-aminobenzoximes using a slight excess of methanesulfonyl chloride and triethylamine at 0−23 °C and is amenable to scale-up. The synthesis of 1H-indazoles under these conditions is extremely mild compared with previous synthetic approaches and affords the desired compounds in good to excellent yields. |
| doi_str_mv | 10.1021/ol800053f |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1523-7060 |
| ispartof | Organic letters, 2008-03, Vol.10 (5), p.1021-1023 |
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| language | eng |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Catalysis Combinatorial Chemistry Techniques Indazoles - chemical synthesis Indazoles - chemistry Molecular Structure Oximes - chemistry |
| title | A Practical, Metal-Free Synthesis of 1H-Indazoles |
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