Binding effect and design of a competitive inhibitory peptide for HMG-CoA reductase through modeling of an active peptide backbone

This study presents an application of two approaches in the design of constrained and unconstrained peptides in an investigation of the peptide binding effect for HMG-CoA reductase (HMGR). In previous works, hypocholesterolemic peptides isolated from soybean were determined as competitive inhibitory...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2008-02, Vol.16 (3), p.1309-1318
Hauptverfasser:	Pak, Valeriy Viktorovich, Koo, Minseon, Kim, Min Jung, Yun, Lyubov, Kwon, Dae Young
Format:	Artikel
Sprache:	eng
Schlagworte:	Active conformation Binding, Competitive Biological and medical sciences Circular Dichroism Databases, Protein Drug Design Enzymes Hydroxymethylglutaryl CoA Reductases - chemistry Hydroxymethylglutaryl CoA Reductases - metabolism Hydroxymethylglutaryl-CoA Reductase Inhibitors - chemical synthesis Hydroxymethylglutaryl-CoA Reductase Inhibitors - chemistry Hydroxymethylglutaryl-CoA Reductase Inhibitors - metabolism Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Inhibition mechanism Inhibitors Medical sciences Miscellaneous Models, Biological Models, Molecular Peptides Peptides - chemical synthesis Peptides - chemistry Peptides - metabolism Peptides - pharmacology Pharmacology. Drug treatments Protein Binding Protein Denaturation Protein Folding Protein Structure, Tertiary Structure-Activity Relationship Temperature
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