Bimodal occurrence of aspartoacylase in myelin and cytosol of brain

The growing use of N‐acetylaspartate as an indicator of neuronal viability has fostered interest in the biological function(s) of this unusual amino acid derivative. In considering the various physiological roles that have been proposed for this relatively abundant molecule one is obliged to take in...

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Veröffentlicht in:	Journal of neurochemistry 2007-04, Vol.101 (2), p.448-457
Hauptverfasser:	Wang, Jianfeng, Matalon, Reuben, Bhatia, Gita, Wu, Gusheng, Li, Hong, Liu, Tong, Lu, Zi‐Hua, Ledeen, Robert W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amidohydrolases - analysis Amidohydrolases - metabolism Animals Aspartic Acid - analogs & derivatives Aspartic Acid - biosynthesis aspartoacylase axon–myelin interaction Biochemistry Biochemistry and metabolism Biological and medical sciences Brain - cytology Brain - enzymology Brain Chemistry - physiology Brain research Cell Membrane - enzymology Central nervous system Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Chromatography, Thin Layer Cytosol - enzymology Enzymes Fundamental and applied biological sciences. Psychology Immunoblotting Membrane Lipids - biosynthesis Mice Mice, Inbred C57BL myelin myelin lipid synthesis Myelin Sheath - enzymology myelin‐localized enzymes Neurons Neurons - enzymology N‐acetylaspartate N‐acetylaspartate assay Oligodendroglia - enzymology Proteomics Vertebrates: nervous system and sense organs
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