Narrowing in on Cardiovascular Disease: The Atheroprotective Role of Peroxisome Proliferator–Activated Receptor γ
Peroxisome proliferator–activated receptor γ (PPAR γ ) is a nuclear receptor that has been suggested to play protective roles in the pathogenesis of diseases that are characterized by chronic inflammation, such as atherosclerosis. The study of nuclear receptors, including PPAR γ , has led to the dis...
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| Veröffentlicht in: | Trends in cardiovascular medicine 2008-02, Vol.18 (2), p.39-44 |
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| creator | Gerry, Jon M Pascual, Gabriel |
| description | Peroxisome proliferator–activated receptor γ (PPAR γ ) is a nuclear receptor that has been suggested to play protective roles in the pathogenesis of diseases that are characterized by chronic inflammation, such as atherosclerosis. The study of nuclear receptors, including PPAR γ , has led to the discovery of anti-inflammatory processes that are collectively known as transrepression. In this review, we will highlight some of the mechanisms of PPAR γ -mediated transrepression that have surfaced throughout the past decade. We will also discuss the existing evidence for an atheroprotective role of PPARγ as a repressor of inflammatory genes and as a key determinant of distinct monocyte-derived subpopulations that may serve an anti-inflammatory, homeostatic role in atherogenesis. |
| doi_str_mv | 10.1016/j.tcm.2007.12.001 |
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| fulltext | fulltext |
| identifier | ISSN: 1050-1738 |
| ispartof | Trends in cardiovascular medicine, 2008-02, Vol.18 (2), p.39-44 |
| issn | 1050-1738 1873-2615 |
| language | eng |
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| source | MEDLINE; ScienceDirect Freedom Collection (Elsevier) |
| subjects | Atherosclerosis - physiopathology Cardiovascular Humans Inflammation Macrophage Activation Macrophages - physiology PPAR gamma - physiology Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - physiology Transcription Factors - physiology |
| title | Narrowing in on Cardiovascular Disease: The Atheroprotective Role of Peroxisome Proliferator–Activated Receptor γ |
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