Overexpression of protease-activated receptors-1,-2, and-4 (PAR-1, -2, and -4) in prostate cancer

BACKGROUND Although protease‐activated receptors (PARs) have been described to play a role in different malignancies, their expression and biological activity in prostate cancer are mostly unknown. METHODS PAR expression in radical prostatectomy specimens was investigated by immunohistochemistry (IH...

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Veröffentlicht in:	The Prostate 2007-05, Vol.67 (7), p.743-756
Hauptverfasser:	Black, Peter C., Mize, Gregory J., Karlin, Peter, Greenberg, Daniel L., Hawley, Sarah J., True, Lawrence D., Vessella, Robert L., Takayama, Thomas K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biological and medical sciences cdc42 GTP-Binding Protein - physiology Cell Movement - physiology Disease-Free Survival Gene Expression Regulation, Neoplastic Gynecology. Andrology. Obstetrics Humans LNCaP Male Male genital diseases Medical sciences Middle Aged Multivariate Analysis Neoplasm Recurrence, Local Nephrology. Urinary tract diseases PAR-1 PAR-2 PAR-4 prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology rac1 GTP-Binding Protein - physiology Receptor, PAR-1 - genetics Receptor, PAR-1 - metabolism Receptor, PAR-2 - genetics Receptor, PAR-2 - metabolism Receptors, Thrombin - genetics Receptors, Thrombin - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction - physiology Tumor Cells, Cultured Tumors Tumors of the urinary system Urinary tract. Prostate gland
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