Differences in Atherosclerotic Profiles Between Patients With Thoracic and Abdominal Aortic Aneurysms
Differences in atherosclerotic profiles between patients with thoracic aortic aneurysm (TAA) and patients with abdominal aortic aneurysm (AAA) have not been studied. We retrospectively studied the clinical records of 343 consecutive patients (132 TAA and 211 AAA) who were admitted to our hospital fo...
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| Veröffentlicht in: | The American journal of cardiology 2008-03, Vol.101 (5), p.696-699 |
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| container_title | The American journal of cardiology |
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| creator | Ito, Shin, MD Akutsu, Koichi, MD Tamori, Yuiichi, MD Sakamoto, Shingo, MD Yoshimuta, Tsuyoshi, MD Hashimoto, Hideki, MD Takeshita, Satoshi, MD |
| description | Differences in atherosclerotic profiles between patients with thoracic aortic aneurysm (TAA) and patients with abdominal aortic aneurysm (AAA) have not been studied. We retrospectively studied the clinical records of 343 consecutive patients (132 TAA and 211 AAA) who were admitted to our hospital for elective repair of aortic aneurysms between July 2001 and December 2004. Clinical variables were compared between patients with TAA and those with AAA by using a univariate analysis, and those achieving statistical significance were subsequently assessed in a multivariate analysis. The incidence of coronary artery disease (CAD) (53% vs 23%, p |
| doi_str_mv | 10.1016/j.amjcard.2007.10.039 |
| format | Article |
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We retrospectively studied the clinical records of 343 consecutive patients (132 TAA and 211 AAA) who were admitted to our hospital for elective repair of aortic aneurysms between July 2001 and December 2004. Clinical variables were compared between patients with TAA and those with AAA by using a univariate analysis, and those achieving statistical significance were subsequently assessed in a multivariate analysis. The incidence of coronary artery disease (CAD) (53% vs 23%, p <0.0001), 3-vessel coronary disease (41% vs 10%, p <0.0001), male gender (86% vs 74%, p <0.01), smoker (88% vs 76%, p <0.01), chronic obstructive pulmonary disease (COPD) (30% vs 15%, p <0.01), and diabetes mellitus (39% vs 23%, p <0.01) were significantly higher in patients with AAA than in those with TAA. In contrast, the incidence of hypertension (91% vs 81%, p <0.05), saccular-type aneurysm (61% vs 7%, p <0.0001), and body mass index (24.1 ± 3.1 vs 23.2 ± 3.5, p <0.05) were significantly higher in patients with TAA than in those with AAA. Multivariate stepwise logistic analysis revealed that CAD (odds ratio [OR] 3.65; 95% confidence interval [CI] 2.12 to 6.42; p <0.0001), COPD (OR 2.05; 95% CI 1.11 to 3.89; p <0.05), and diabetes mellitus (OR 1.85; 95% CI 1.06 to 3.27; p <0.05) were associated with AAA, and that body mass index (OR 9.39; 95% CI 2.0 to 46.8; p <0.01), hypertension (OR 3.09; 95% CI 1.48 to 6.87; p <0.01), and cerebral infarction (OR 2.83; 95% CI 1.25 to 6.50; p <0.05) were associated with TAA. In conclusion, atherosclerotic profiles are significantly different between patients with TAA and patients with AAA. This result suggests the possibility that mechanisms underlying the development of aortic aneurysms may differ between TAA and AAA, and, from the perspective of prevention, provides further stimulus for the modification of key risk factors for atherosclerosis.]]></description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2007.10.039</identifier><identifier>PMID: 18308024</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Aged ; Aneurysms ; Aortic Aneurysm, Abdominal - epidemiology ; Aortic Aneurysm, Thoracic - epidemiology ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; Body Mass Index ; Cardiology ; Cardiology. Vascular system ; Cardiovascular ; Cardiovascular disease ; Cerebral Infarction - epidemiology ; Coronary Artery Disease - epidemiology ; Diabetes Mellitus - epidemiology ; Diseases of the aorta ; Female ; Humans ; Hypertension ; Hypertension - epidemiology ; Male ; Medical sciences ; Multivariate Analysis ; Pulmonary Disease, Chronic Obstructive - epidemiology ; Retrospective Studies ; Risk factors ; Studies</subject><ispartof>The American journal of cardiology, 2008-03, Vol.101 (5), p.696-699</ispartof><rights>Elsevier Inc.</rights><rights>2008 Elsevier Inc.</rights><rights>2008 INIST-CNRS</rights><rights>Copyright Elsevier Sequoia S.A. Mar 1, 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-15f33e9a035e0f19e7188d4ab6d8f8c6effcecd06db8889b106c0485e2463bfe3</citedby><cites>FETCH-LOGICAL-c475t-15f33e9a035e0f19e7188d4ab6d8f8c6effcecd06db8889b106c0485e2463bfe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.amjcard.2007.10.039$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20128314$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18308024$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ito, Shin, MD</creatorcontrib><creatorcontrib>Akutsu, Koichi, MD</creatorcontrib><creatorcontrib>Tamori, Yuiichi, MD</creatorcontrib><creatorcontrib>Sakamoto, Shingo, MD</creatorcontrib><creatorcontrib>Yoshimuta, Tsuyoshi, MD</creatorcontrib><creatorcontrib>Hashimoto, Hideki, MD</creatorcontrib><creatorcontrib>Takeshita, Satoshi, MD</creatorcontrib><title>Differences in Atherosclerotic Profiles Between Patients With Thoracic and Abdominal Aortic Aneurysms</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description><![CDATA[Differences in atherosclerotic profiles between patients with thoracic aortic aneurysm (TAA) and patients with abdominal aortic aneurysm (AAA) have not been studied. We retrospectively studied the clinical records of 343 consecutive patients (132 TAA and 211 AAA) who were admitted to our hospital for elective repair of aortic aneurysms between July 2001 and December 2004. Clinical variables were compared between patients with TAA and those with AAA by using a univariate analysis, and those achieving statistical significance were subsequently assessed in a multivariate analysis. The incidence of coronary artery disease (CAD) (53% vs 23%, p <0.0001), 3-vessel coronary disease (41% vs 10%, p <0.0001), male gender (86% vs 74%, p <0.01), smoker (88% vs 76%, p <0.01), chronic obstructive pulmonary disease (COPD) (30% vs 15%, p <0.01), and diabetes mellitus (39% vs 23%, p <0.01) were significantly higher in patients with AAA than in those with TAA. In contrast, the incidence of hypertension (91% vs 81%, p <0.05), saccular-type aneurysm (61% vs 7%, p <0.0001), and body mass index (24.1 ± 3.1 vs 23.2 ± 3.5, p <0.05) were significantly higher in patients with TAA than in those with AAA. Multivariate stepwise logistic analysis revealed that CAD (odds ratio [OR] 3.65; 95% confidence interval [CI] 2.12 to 6.42; p <0.0001), COPD (OR 2.05; 95% CI 1.11 to 3.89; p <0.05), and diabetes mellitus (OR 1.85; 95% CI 1.06 to 3.27; p <0.05) were associated with AAA, and that body mass index (OR 9.39; 95% CI 2.0 to 46.8; p <0.01), hypertension (OR 3.09; 95% CI 1.48 to 6.87; p <0.01), and cerebral infarction (OR 2.83; 95% CI 1.25 to 6.50; p <0.05) were associated with TAA. In conclusion, atherosclerotic profiles are significantly different between patients with TAA and patients with AAA. This result suggests the possibility that mechanisms underlying the development of aortic aneurysms may differ between TAA and AAA, and, from the perspective of prevention, provides further stimulus for the modification of key risk factors for atherosclerosis.]]></description><subject>Aged</subject><subject>Aneurysms</subject><subject>Aortic Aneurysm, Abdominal - epidemiology</subject><subject>Aortic Aneurysm, Thoracic - epidemiology</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Body Mass Index</subject><subject>Cardiology</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular</subject><subject>Cardiovascular disease</subject><subject>Cerebral Infarction - epidemiology</subject><subject>Coronary Artery Disease - epidemiology</subject><subject>Diabetes Mellitus - epidemiology</subject><subject>Diseases of the aorta</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - epidemiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Multivariate Analysis</subject><subject>Pulmonary Disease, Chronic Obstructive - epidemiology</subject><subject>Retrospective Studies</subject><subject>Risk factors</subject><subject>Studies</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkl2L1TAQhoMo7nH1JyhF0LseZ5p-pDdKXT9hwQVXvAxpOuGktulu0irn35tyygp7401CJs9MJu87jD1H2CNg-abfq7HXynf7DKCKsT3w-gHboajqFGvkD9kOALK0xrw-Y09C6OMRsSgfszMUHARk-Y7RB2sMeXKaQmJd0swH8lPQQ1xnq5MrPxk7xLv3NP8hcsmVmi25OSQ_7XxIrg-TVzpyynVJ03bTaJ0akmbya3LjaPHHMIan7JFRQ6Bn237Ofnz6eH3xJb389vnrRXOZ6rwq5hQLwznVCnhBYLCmCoXoctWWnTBCl2SMJt1B2bVCiLpFKDXkoqAsL3lriJ-z16e6N366XSjMcrRB0zAoR9MSZAU85zViBF_eA_tp8bH1IDMOvMpLyCNUnCAdFQmejLzxdlT-KBHkaoLs5WaCXE1Yw9GEmPdiK760I3X_sjbVI_BqA1TQajBeOW3DHZcBZoLjyr07cRQ1-23Jy6DtalVnPelZdpP9bytv71XQg3U2PvqLjhTuPo0yZBLk93Vi1oGBCjIsolh_AS1AvPg</recordid><startdate>20080301</startdate><enddate>20080301</enddate><creator>Ito, Shin, MD</creator><creator>Akutsu, Koichi, MD</creator><creator>Tamori, Yuiichi, MD</creator><creator>Sakamoto, Shingo, MD</creator><creator>Yoshimuta, Tsuyoshi, MD</creator><creator>Hashimoto, Hideki, MD</creator><creator>Takeshita, Satoshi, MD</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20080301</creationdate><title>Differences in Atherosclerotic Profiles Between Patients With Thoracic and Abdominal Aortic Aneurysms</title><author>Ito, Shin, MD ; Akutsu, Koichi, MD ; Tamori, Yuiichi, MD ; Sakamoto, Shingo, MD ; Yoshimuta, Tsuyoshi, MD ; Hashimoto, Hideki, MD ; Takeshita, Satoshi, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-15f33e9a035e0f19e7188d4ab6d8f8c6effcecd06db8889b106c0485e2463bfe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aged</topic><topic>Aneurysms</topic><topic>Aortic Aneurysm, Abdominal - epidemiology</topic><topic>Aortic Aneurysm, Thoracic - epidemiology</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Body Mass Index</topic><topic>Cardiology</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular</topic><topic>Cardiovascular disease</topic><topic>Cerebral Infarction - epidemiology</topic><topic>Coronary Artery Disease - epidemiology</topic><topic>Diabetes Mellitus - epidemiology</topic><topic>Diseases of the aorta</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - epidemiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Multivariate Analysis</topic><topic>Pulmonary Disease, Chronic Obstructive - epidemiology</topic><topic>Retrospective Studies</topic><topic>Risk factors</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ito, Shin, MD</creatorcontrib><creatorcontrib>Akutsu, Koichi, MD</creatorcontrib><creatorcontrib>Tamori, Yuiichi, MD</creatorcontrib><creatorcontrib>Sakamoto, Shingo, MD</creatorcontrib><creatorcontrib>Yoshimuta, Tsuyoshi, MD</creatorcontrib><creatorcontrib>Hashimoto, Hideki, MD</creatorcontrib><creatorcontrib>Takeshita, Satoshi, MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ito, Shin, MD</au><au>Akutsu, Koichi, MD</au><au>Tamori, Yuiichi, MD</au><au>Sakamoto, Shingo, MD</au><au>Yoshimuta, Tsuyoshi, MD</au><au>Hashimoto, Hideki, MD</au><au>Takeshita, Satoshi, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differences in Atherosclerotic Profiles Between Patients With Thoracic and Abdominal Aortic Aneurysms</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>2008-03-01</date><risdate>2008</risdate><volume>101</volume><issue>5</issue><spage>696</spage><epage>699</epage><pages>696-699</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract><![CDATA[Differences in atherosclerotic profiles between patients with thoracic aortic aneurysm (TAA) and patients with abdominal aortic aneurysm (AAA) have not been studied. We retrospectively studied the clinical records of 343 consecutive patients (132 TAA and 211 AAA) who were admitted to our hospital for elective repair of aortic aneurysms between July 2001 and December 2004. Clinical variables were compared between patients with TAA and those with AAA by using a univariate analysis, and those achieving statistical significance were subsequently assessed in a multivariate analysis. The incidence of coronary artery disease (CAD) (53% vs 23%, p <0.0001), 3-vessel coronary disease (41% vs 10%, p <0.0001), male gender (86% vs 74%, p <0.01), smoker (88% vs 76%, p <0.01), chronic obstructive pulmonary disease (COPD) (30% vs 15%, p <0.01), and diabetes mellitus (39% vs 23%, p <0.01) were significantly higher in patients with AAA than in those with TAA. In contrast, the incidence of hypertension (91% vs 81%, p <0.05), saccular-type aneurysm (61% vs 7%, p <0.0001), and body mass index (24.1 ± 3.1 vs 23.2 ± 3.5, p <0.05) were significantly higher in patients with TAA than in those with AAA. Multivariate stepwise logistic analysis revealed that CAD (odds ratio [OR] 3.65; 95% confidence interval [CI] 2.12 to 6.42; p <0.0001), COPD (OR 2.05; 95% CI 1.11 to 3.89; p <0.05), and diabetes mellitus (OR 1.85; 95% CI 1.06 to 3.27; p <0.05) were associated with AAA, and that body mass index (OR 9.39; 95% CI 2.0 to 46.8; p <0.01), hypertension (OR 3.09; 95% CI 1.48 to 6.87; p <0.01), and cerebral infarction (OR 2.83; 95% CI 1.25 to 6.50; p <0.05) were associated with TAA. In conclusion, atherosclerotic profiles are significantly different between patients with TAA and patients with AAA. This result suggests the possibility that mechanisms underlying the development of aortic aneurysms may differ between TAA and AAA, and, from the perspective of prevention, provides further stimulus for the modification of key risk factors for atherosclerosis.]]></abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>18308024</pmid><doi>10.1016/j.amjcard.2007.10.039</doi><tpages>4</tpages></addata></record> |
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| subjects | Aged Aneurysms Aortic Aneurysm, Abdominal - epidemiology Aortic Aneurysm, Thoracic - epidemiology Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Body Mass Index Cardiology Cardiology. Vascular system Cardiovascular Cardiovascular disease Cerebral Infarction - epidemiology Coronary Artery Disease - epidemiology Diabetes Mellitus - epidemiology Diseases of the aorta Female Humans Hypertension Hypertension - epidemiology Male Medical sciences Multivariate Analysis Pulmonary Disease, Chronic Obstructive - epidemiology Retrospective Studies Risk factors Studies |
| title | Differences in Atherosclerotic Profiles Between Patients With Thoracic and Abdominal Aortic Aneurysms |
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