The role of postoperative radiotherapy in node negative breast cancer patients with pT3–T4 disease
Abstract Aims To evaluate the role of postmastectomy radiotherapy (PMRT) in patients with pT3–T4N0M0 breast cancer. Methods 156 patients with T3–T4N0M0 breast cancer were retrospectively analyzed. Results Locoregional recurrences were seen in 17 of 156 patients with a median time for development of...
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| Veröffentlicht in: | European journal of surgical oncology 2007-04, Vol.33 (3), p.285-293 |
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| creator | Aksu, G Kucucuk, S Fayda, M Saynak, M Baskaya, S Saip, P Ozturk, N Aslay, I |
| description | Abstract Aims To evaluate the role of postmastectomy radiotherapy (PMRT) in patients with pT3–T4N0M0 breast cancer. Methods 156 patients with T3–T4N0M0 breast cancer were retrospectively analyzed. Results Locoregional recurrences were seen in 17 of 156 patients with a median time for development of 27 months (5.7–248.7 months). Two of 9 patients who were not treated with post-operative radiation therapy had locoregional recurrence as compared with 16 of 147 patients receiving radiotherapy. In multivariate analysis, presence of locoregional recurrence was the only significant prognostic factor for overall survival (18% vs. 86%, p < 0.001, RR = 9.05). The patients with a median number of dissected lymph nodes ≥10 had a significantly better locoregional disease free survival rate as compared with patients with dissected lymph nodes |
| doi_str_mv | 10.1016/j.ejso.2006.10.037 |
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Methods 156 patients with T3–T4N0M0 breast cancer were retrospectively analyzed. Results Locoregional recurrences were seen in 17 of 156 patients with a median time for development of 27 months (5.7–248.7 months). Two of 9 patients who were not treated with post-operative radiation therapy had locoregional recurrence as compared with 16 of 147 patients receiving radiotherapy. In multivariate analysis, presence of locoregional recurrence was the only significant prognostic factor for overall survival (18% vs. 86%, p < 0.001, RR = 9.05). The patients with a median number of dissected lymph nodes ≥10 had a significantly better locoregional disease free survival rate as compared with patients with dissected lymph nodes <10 (90% vs. 78%, p = 0.04). Chest wall recurrences were clearly higher in patients without chest wall RT since 5 of 49 patients without RT had recurrences in the chest wall region while only 4 of 107 who received chest wall RT had recurrence. However receiving RT to peripherical lymphatic regions had no additional effect on reducing recurrences in these regions (5% vs. 4%). Conclusions Due to the lack of phase III randomized trials directly addressing the role of postmastectomy radiotherapy in these stages, our series suggest that postmastectomy radiotherapy to the ipsilateral chest wall is recommended for patients with PT3N0 and T4N0 breast cancer. The need for irradiating axillary or supraclavicular region shall be neglected in patients who undergo sufficient axillary sampling.</description><identifier>ISSN: 0748-7983</identifier><identifier>EISSN: 1532-2157</identifier><identifier>DOI: 10.1016/j.ejso.2006.10.037</identifier><identifier>PMID: 17145158</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adult ; Aged ; Antineoplastic Agents - therapeutic use ; Breast cancer ; Breast Neoplasms - drug therapy ; Breast Neoplasms - pathology ; Breast Neoplasms - radiotherapy ; Breast Neoplasms - surgery ; Chemotherapy, Adjuvant ; Chi-Square Distribution ; Combined Modality Therapy ; Female ; Hematology, Oncology and Palliative Medicine ; Humans ; Locoregional recurrence ; Mastectomy ; Middle Aged ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Node-negative disease ; Postoperative Period ; Prognosis ; Prognostic factors ; Proportional Hazards Models ; Radiotherapy ; Radiotherapy Dosage ; Radiotherapy, Adjuvant ; Retrospective Studies ; Surgery ; Survival Analysis ; T3N0 ; Treatment Outcome</subject><ispartof>European journal of surgical oncology, 2007-04, Vol.33 (3), p.285-293</ispartof><rights>Elsevier Ltd</rights><rights>2006 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-f552721e48ba4d699d96e1cb4aca4d6a2eec479e72d0b40af9521b12dd2da9e33</citedby><cites>FETCH-LOGICAL-c409t-f552721e48ba4d699d96e1cb4aca4d6a2eec479e72d0b40af9521b12dd2da9e33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejso.2006.10.037$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17145158$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aksu, G</creatorcontrib><creatorcontrib>Kucucuk, S</creatorcontrib><creatorcontrib>Fayda, M</creatorcontrib><creatorcontrib>Saynak, M</creatorcontrib><creatorcontrib>Baskaya, S</creatorcontrib><creatorcontrib>Saip, P</creatorcontrib><creatorcontrib>Ozturk, N</creatorcontrib><creatorcontrib>Aslay, I</creatorcontrib><title>The role of postoperative radiotherapy in node negative breast cancer patients with pT3–T4 disease</title><title>European journal of surgical oncology</title><addtitle>Eur J Surg Oncol</addtitle><description>Abstract Aims To evaluate the role of postmastectomy radiotherapy (PMRT) in patients with pT3–T4N0M0 breast cancer. Methods 156 patients with T3–T4N0M0 breast cancer were retrospectively analyzed. Results Locoregional recurrences were seen in 17 of 156 patients with a median time for development of 27 months (5.7–248.7 months). Two of 9 patients who were not treated with post-operative radiation therapy had locoregional recurrence as compared with 16 of 147 patients receiving radiotherapy. In multivariate analysis, presence of locoregional recurrence was the only significant prognostic factor for overall survival (18% vs. 86%, p < 0.001, RR = 9.05). The patients with a median number of dissected lymph nodes ≥10 had a significantly better locoregional disease free survival rate as compared with patients with dissected lymph nodes <10 (90% vs. 78%, p = 0.04). Chest wall recurrences were clearly higher in patients without chest wall RT since 5 of 49 patients without RT had recurrences in the chest wall region while only 4 of 107 who received chest wall RT had recurrence. However receiving RT to peripherical lymphatic regions had no additional effect on reducing recurrences in these regions (5% vs. 4%). Conclusions Due to the lack of phase III randomized trials directly addressing the role of postmastectomy radiotherapy in these stages, our series suggest that postmastectomy radiotherapy to the ipsilateral chest wall is recommended for patients with PT3N0 and T4N0 breast cancer. The need for irradiating axillary or supraclavicular region shall be neglected in patients who undergo sufficient axillary sampling.</description><subject>Adult</subject><subject>Aged</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - radiotherapy</subject><subject>Breast Neoplasms - surgery</subject><subject>Chemotherapy, Adjuvant</subject><subject>Chi-Square Distribution</subject><subject>Combined Modality Therapy</subject><subject>Female</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Locoregional recurrence</subject><subject>Mastectomy</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local</subject><subject>Neoplasm Staging</subject><subject>Node-negative disease</subject><subject>Postoperative Period</subject><subject>Prognosis</subject><subject>Prognostic factors</subject><subject>Proportional Hazards Models</subject><subject>Radiotherapy</subject><subject>Radiotherapy Dosage</subject><subject>Radiotherapy, Adjuvant</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Survival Analysis</subject><subject>T3N0</subject><subject>Treatment Outcome</subject><issn>0748-7983</issn><issn>1532-2157</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2KFDEUhYMoTjv6Ai4kK3fV3vxUpQIiyOAfDLiwXYdUcstOWV0pk-oZeuc7-IY-iSm6QXDhJuGenHMg3yXkOYMtA9a8GrY45LjlAE0RtiDUA7JhteAVZ7V6SDagZFsp3Yor8iTnAQC0UPoxuWKKyZrV7Yb43R5piiPS2NM55iXOmOwS7opqfYjLvozziYaJTtEjnfDb-bVLaPNCnZ0cJjoXEacl0_uw7Om8E79__tpJ6kMuLnxKHvV2zPjscl-Tr-_f7W4-VrefP3y6eXtbOQl6qfq65oozlG1npW-09rpB5jpp3Tpbjuik0qi4h06C7XXNWce499xbjUJck5fn3jnFH0fMizmE7HAc7YTxmI0CIUXbtMXIz0aXYs4JezOncLDpZBiYla0ZzMrWrGxXrbAtoReX9mN3QP83coFZDK_PBix_vAuYTHaFikMfErrF-Bj-3__mn7gbwxScHb_jCfMQj2kq9AwzmRswX9btrsuFBkCWU_wBdneiDw</recordid><startdate>20070401</startdate><enddate>20070401</enddate><creator>Aksu, G</creator><creator>Kucucuk, S</creator><creator>Fayda, M</creator><creator>Saynak, M</creator><creator>Baskaya, S</creator><creator>Saip, P</creator><creator>Ozturk, N</creator><creator>Aslay, I</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070401</creationdate><title>The role of postoperative radiotherapy in node negative breast cancer patients with pT3–T4 disease</title><author>Aksu, G ; Kucucuk, S ; Fayda, M ; Saynak, M ; Baskaya, S ; Saip, P ; Ozturk, N ; Aslay, I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-f552721e48ba4d699d96e1cb4aca4d6a2eec479e72d0b40af9521b12dd2da9e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - radiotherapy</topic><topic>Breast Neoplasms - surgery</topic><topic>Chemotherapy, Adjuvant</topic><topic>Chi-Square Distribution</topic><topic>Combined Modality Therapy</topic><topic>Female</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Locoregional recurrence</topic><topic>Mastectomy</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local</topic><topic>Neoplasm Staging</topic><topic>Node-negative disease</topic><topic>Postoperative Period</topic><topic>Prognosis</topic><topic>Prognostic factors</topic><topic>Proportional Hazards Models</topic><topic>Radiotherapy</topic><topic>Radiotherapy Dosage</topic><topic>Radiotherapy, Adjuvant</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Survival Analysis</topic><topic>T3N0</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aksu, G</creatorcontrib><creatorcontrib>Kucucuk, S</creatorcontrib><creatorcontrib>Fayda, M</creatorcontrib><creatorcontrib>Saynak, M</creatorcontrib><creatorcontrib>Baskaya, S</creatorcontrib><creatorcontrib>Saip, P</creatorcontrib><creatorcontrib>Ozturk, N</creatorcontrib><creatorcontrib>Aslay, I</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aksu, G</au><au>Kucucuk, S</au><au>Fayda, M</au><au>Saynak, M</au><au>Baskaya, S</au><au>Saip, P</au><au>Ozturk, N</au><au>Aslay, I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of postoperative radiotherapy in node negative breast cancer patients with pT3–T4 disease</atitle><jtitle>European journal of surgical oncology</jtitle><addtitle>Eur J Surg Oncol</addtitle><date>2007-04-01</date><risdate>2007</risdate><volume>33</volume><issue>3</issue><spage>285</spage><epage>293</epage><pages>285-293</pages><issn>0748-7983</issn><eissn>1532-2157</eissn><abstract>Abstract Aims To evaluate the role of postmastectomy radiotherapy (PMRT) in patients with pT3–T4N0M0 breast cancer. Methods 156 patients with T3–T4N0M0 breast cancer were retrospectively analyzed. Results Locoregional recurrences were seen in 17 of 156 patients with a median time for development of 27 months (5.7–248.7 months). Two of 9 patients who were not treated with post-operative radiation therapy had locoregional recurrence as compared with 16 of 147 patients receiving radiotherapy. In multivariate analysis, presence of locoregional recurrence was the only significant prognostic factor for overall survival (18% vs. 86%, p < 0.001, RR = 9.05). The patients with a median number of dissected lymph nodes ≥10 had a significantly better locoregional disease free survival rate as compared with patients with dissected lymph nodes <10 (90% vs. 78%, p = 0.04). Chest wall recurrences were clearly higher in patients without chest wall RT since 5 of 49 patients without RT had recurrences in the chest wall region while only 4 of 107 who received chest wall RT had recurrence. However receiving RT to peripherical lymphatic regions had no additional effect on reducing recurrences in these regions (5% vs. 4%). Conclusions Due to the lack of phase III randomized trials directly addressing the role of postmastectomy radiotherapy in these stages, our series suggest that postmastectomy radiotherapy to the ipsilateral chest wall is recommended for patients with PT3N0 and T4N0 breast cancer. The need for irradiating axillary or supraclavicular region shall be neglected in patients who undergo sufficient axillary sampling.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>17145158</pmid><doi>10.1016/j.ejso.2006.10.037</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult Aged Antineoplastic Agents - therapeutic use Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - pathology Breast Neoplasms - radiotherapy Breast Neoplasms - surgery Chemotherapy, Adjuvant Chi-Square Distribution Combined Modality Therapy Female Hematology, Oncology and Palliative Medicine Humans Locoregional recurrence Mastectomy Middle Aged Neoplasm Recurrence, Local Neoplasm Staging Node-negative disease Postoperative Period Prognosis Prognostic factors Proportional Hazards Models Radiotherapy Radiotherapy Dosage Radiotherapy, Adjuvant Retrospective Studies Surgery Survival Analysis T3N0 Treatment Outcome |
| title | The role of postoperative radiotherapy in node negative breast cancer patients with pT3–T4 disease |
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