Indices of platelet activation and the stability of coronary artery disease
Aim: To determine whether indices of platelet activation are associated with the stability of coronary artery disease (CAD). Methods: Platelet function was examined in 677 consecutive aspirin‐treated patients presenting for cardiac catheterization. Patients were grouped into recent myocardial infa...
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| Veröffentlicht in: | Journal of thrombosis and haemostasis 2007-04, Vol.5 (4), p.761-765 |
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| creator | LINDEN, M. D. FURMAN, M. I. FRELINGER, A.L. FOX, M. L. BARNARD, M. R. LI, Y. PRZYKLENK, K. MICHELSON, A. D. |
| description | Aim: To determine whether indices of platelet activation are associated with the stability of coronary artery disease (CAD).
Methods: Platelet function was examined in 677 consecutive aspirin‐treated patients presenting for cardiac catheterization. Patients were grouped into recent myocardial infarction (MI), no MI but angiographically documented CAD (non‐MI CAD) and no angiographically detectible CAD (no CAD), as well as additional subgroups.
Results: Compared with non‐MI CAD or no CAD patients, more patients with recent MI had a shortened platelet function analyzer (PFA)‐100 collagen‐epinephrine closure time (CT) and increased circulating monocyte‐platelet aggregates, neutrophil‐platelet aggregates, activated platelet surface GPIIb‐IIIa and plasma soluble CD40 ligand (sCD40L). More patients with non‐MI CAD had shortened PFA‐100 CTs and increased monocyte‐platelet aggregates compared with patients with no CAD. Platelet surface P‐selectin did not differ among the groups. Subgroup analysis revealed that decreasing PFA‐100 CT correlated with the stability of CAD.
Conclusions: Indices of platelet activation, especially the PFA‐100 CT, are associated with the stability of CAD, and may reflect plaque instability, an ongoing thrombotic state and/or reduced responsiveness to aspirin. |
| doi_str_mv | 10.1111/j.1538-7836.2007.02462.x |
| format | Article |
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Methods: Platelet function was examined in 677 consecutive aspirin‐treated patients presenting for cardiac catheterization. Patients were grouped into recent myocardial infarction (MI), no MI but angiographically documented CAD (non‐MI CAD) and no angiographically detectible CAD (no CAD), as well as additional subgroups.
Results: Compared with non‐MI CAD or no CAD patients, more patients with recent MI had a shortened platelet function analyzer (PFA)‐100 collagen‐epinephrine closure time (CT) and increased circulating monocyte‐platelet aggregates, neutrophil‐platelet aggregates, activated platelet surface GPIIb‐IIIa and plasma soluble CD40 ligand (sCD40L). More patients with non‐MI CAD had shortened PFA‐100 CTs and increased monocyte‐platelet aggregates compared with patients with no CAD. Platelet surface P‐selectin did not differ among the groups. Subgroup analysis revealed that decreasing PFA‐100 CT correlated with the stability of CAD.
Conclusions: Indices of platelet activation, especially the PFA‐100 CT, are associated with the stability of CAD, and may reflect plaque instability, an ongoing thrombotic state and/or reduced responsiveness to aspirin.</description><identifier>ISSN: 1538-7933</identifier><identifier>ISSN: 1538-7836</identifier><identifier>EISSN: 1538-7836</identifier><identifier>DOI: 10.1111/j.1538-7836.2007.02462.x</identifier><identifier>PMID: 17371489</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Aged ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; aspirin ; Aspirin - pharmacology ; CD40 Ligand - metabolism ; coronary artery disease ; Coronary Artery Disease - blood ; Coronary Artery Disease - diagnosis ; Coronary Artery Disease - therapy ; Epinephrine - metabolism ; Female ; flow cytometry ; Humans ; Male ; Middle Aged ; Neutrophils - metabolism ; P-Selectin - biosynthesis ; PFA‐100 ; Platelet Activation ; Platelet Function Tests ; Platelet Glycoprotein GPIIb-IIIa Complex - metabolism ; platelets</subject><ispartof>Journal of thrombosis and haemostasis, 2007-04, Vol.5 (4), p.761-765</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4172-a9387d40db85a030394b56665ab88c5009e434525c707001555bfe00ad0d43a73</citedby><cites>FETCH-LOGICAL-c4172-a9387d40db85a030394b56665ab88c5009e434525c707001555bfe00ad0d43a73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17371489$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LINDEN, M. D.</creatorcontrib><creatorcontrib>FURMAN, M. I.</creatorcontrib><creatorcontrib>FRELINGER, A.L.</creatorcontrib><creatorcontrib>FOX, M. L.</creatorcontrib><creatorcontrib>BARNARD, M. R.</creatorcontrib><creatorcontrib>LI, Y.</creatorcontrib><creatorcontrib>PRZYKLENK, K.</creatorcontrib><creatorcontrib>MICHELSON, A. D.</creatorcontrib><title>Indices of platelet activation and the stability of coronary artery disease</title><title>Journal of thrombosis and haemostasis</title><addtitle>J Thromb Haemost</addtitle><description>Aim: To determine whether indices of platelet activation are associated with the stability of coronary artery disease (CAD).
Methods: Platelet function was examined in 677 consecutive aspirin‐treated patients presenting for cardiac catheterization. Patients were grouped into recent myocardial infarction (MI), no MI but angiographically documented CAD (non‐MI CAD) and no angiographically detectible CAD (no CAD), as well as additional subgroups.
Results: Compared with non‐MI CAD or no CAD patients, more patients with recent MI had a shortened platelet function analyzer (PFA)‐100 collagen‐epinephrine closure time (CT) and increased circulating monocyte‐platelet aggregates, neutrophil‐platelet aggregates, activated platelet surface GPIIb‐IIIa and plasma soluble CD40 ligand (sCD40L). More patients with non‐MI CAD had shortened PFA‐100 CTs and increased monocyte‐platelet aggregates compared with patients with no CAD. Platelet surface P‐selectin did not differ among the groups. Subgroup analysis revealed that decreasing PFA‐100 CT correlated with the stability of CAD.
Conclusions: Indices of platelet activation, especially the PFA‐100 CT, are associated with the stability of CAD, and may reflect plaque instability, an ongoing thrombotic state and/or reduced responsiveness to aspirin.</description><subject>Aged</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>aspirin</subject><subject>Aspirin - pharmacology</subject><subject>CD40 Ligand - metabolism</subject><subject>coronary artery disease</subject><subject>Coronary Artery Disease - blood</subject><subject>Coronary Artery Disease - diagnosis</subject><subject>Coronary Artery Disease - therapy</subject><subject>Epinephrine - metabolism</subject><subject>Female</subject><subject>flow cytometry</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neutrophils - metabolism</subject><subject>P-Selectin - biosynthesis</subject><subject>PFA‐100</subject><subject>Platelet Activation</subject><subject>Platelet Function Tests</subject><subject>Platelet Glycoprotein GPIIb-IIIa Complex - metabolism</subject><subject>platelets</subject><issn>1538-7933</issn><issn>1538-7836</issn><issn>1538-7836</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkD1PwzAQQC0EolD4C8gTW8I5tmNnYEAV0EIlljJbju0IV2lSYhfaf09CC6zccifduw89hDCBlPRxs0wJpzIRkuZpBiBSyFiepdsjdPbbOP6pC0pH6DyEJQApeAanaEQEFYTJ4gw9zxrrjQu4rfC61tHVLmJtov_Q0bcN1o3F8c3hEHXpax93A2jarm10t8O6i65P1geng7tAJ5Wug7s85DF6fbhfTKbJ_OVxNrmbJ4YRkSW6oFJYBraUXAMFWrCS53nOdSml4QCFY5TxjBsBov-Zc15WDkBbsIxqQcfoer933bXvGxeiWvlgXF3rxrWboARQRjPCelDuQdO1IXSuUuvOr_rHFQE1iFRLNThSgy81iFTfItW2H7063NiUK2f_Bg_meuB2D3z62u3-vVg9LaZDRb8Ar8-AjA</recordid><startdate>200704</startdate><enddate>200704</enddate><creator>LINDEN, M. D.</creator><creator>FURMAN, M. I.</creator><creator>FRELINGER, A.L.</creator><creator>FOX, M. L.</creator><creator>BARNARD, M. R.</creator><creator>LI, Y.</creator><creator>PRZYKLENK, K.</creator><creator>MICHELSON, A. D.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200704</creationdate><title>Indices of platelet activation and the stability of coronary artery disease</title><author>LINDEN, M. D. ; FURMAN, M. I. ; FRELINGER, A.L. ; FOX, M. L. ; BARNARD, M. R. ; LI, Y. ; PRZYKLENK, K. ; MICHELSON, A. D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4172-a9387d40db85a030394b56665ab88c5009e434525c707001555bfe00ad0d43a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aged</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</topic><topic>aspirin</topic><topic>Aspirin - pharmacology</topic><topic>CD40 Ligand - metabolism</topic><topic>coronary artery disease</topic><topic>Coronary Artery Disease - blood</topic><topic>Coronary Artery Disease - diagnosis</topic><topic>Coronary Artery Disease - therapy</topic><topic>Epinephrine - metabolism</topic><topic>Female</topic><topic>flow cytometry</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neutrophils - metabolism</topic><topic>P-Selectin - biosynthesis</topic><topic>PFA‐100</topic><topic>Platelet Activation</topic><topic>Platelet Function Tests</topic><topic>Platelet Glycoprotein GPIIb-IIIa Complex - metabolism</topic><topic>platelets</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LINDEN, M. D.</creatorcontrib><creatorcontrib>FURMAN, M. I.</creatorcontrib><creatorcontrib>FRELINGER, A.L.</creatorcontrib><creatorcontrib>FOX, M. L.</creatorcontrib><creatorcontrib>BARNARD, M. R.</creatorcontrib><creatorcontrib>LI, Y.</creatorcontrib><creatorcontrib>PRZYKLENK, K.</creatorcontrib><creatorcontrib>MICHELSON, A. D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of thrombosis and haemostasis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LINDEN, M. D.</au><au>FURMAN, M. I.</au><au>FRELINGER, A.L.</au><au>FOX, M. L.</au><au>BARNARD, M. R.</au><au>LI, Y.</au><au>PRZYKLENK, K.</au><au>MICHELSON, A. D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Indices of platelet activation and the stability of coronary artery disease</atitle><jtitle>Journal of thrombosis and haemostasis</jtitle><addtitle>J Thromb Haemost</addtitle><date>2007-04</date><risdate>2007</risdate><volume>5</volume><issue>4</issue><spage>761</spage><epage>765</epage><pages>761-765</pages><issn>1538-7933</issn><issn>1538-7836</issn><eissn>1538-7836</eissn><abstract>Aim: To determine whether indices of platelet activation are associated with the stability of coronary artery disease (CAD).
Methods: Platelet function was examined in 677 consecutive aspirin‐treated patients presenting for cardiac catheterization. Patients were grouped into recent myocardial infarction (MI), no MI but angiographically documented CAD (non‐MI CAD) and no angiographically detectible CAD (no CAD), as well as additional subgroups.
Results: Compared with non‐MI CAD or no CAD patients, more patients with recent MI had a shortened platelet function analyzer (PFA)‐100 collagen‐epinephrine closure time (CT) and increased circulating monocyte‐platelet aggregates, neutrophil‐platelet aggregates, activated platelet surface GPIIb‐IIIa and plasma soluble CD40 ligand (sCD40L). More patients with non‐MI CAD had shortened PFA‐100 CTs and increased monocyte‐platelet aggregates compared with patients with no CAD. Platelet surface P‐selectin did not differ among the groups. Subgroup analysis revealed that decreasing PFA‐100 CT correlated with the stability of CAD.
Conclusions: Indices of platelet activation, especially the PFA‐100 CT, are associated with the stability of CAD, and may reflect plaque instability, an ongoing thrombotic state and/or reduced responsiveness to aspirin.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17371489</pmid><doi>10.1111/j.1538-7836.2007.02462.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Anti-Inflammatory Agents, Non-Steroidal - pharmacology aspirin Aspirin - pharmacology CD40 Ligand - metabolism coronary artery disease Coronary Artery Disease - blood Coronary Artery Disease - diagnosis Coronary Artery Disease - therapy Epinephrine - metabolism Female flow cytometry Humans Male Middle Aged Neutrophils - metabolism P-Selectin - biosynthesis PFA‐100 Platelet Activation Platelet Function Tests Platelet Glycoprotein GPIIb-IIIa Complex - metabolism platelets |
| title | Indices of platelet activation and the stability of coronary artery disease |
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