Platelet-Derived Microparticles and Platelet Count in Preterm Newborns
Objective: Does formation of platelet-derived microparticles correspond to platelet activation? Methods: The study was performed in 51 preterm newborns, 25 girls and 26 boys. The control group consisted of 55 term newborns, 25 girls and 30 boys. Blood samples were collected from the umbilical artery...
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| Veröffentlicht in: | Fetal diagnosis and therapy 2008-01, Vol.23 (2), p.149-152 |
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| container_title | Fetal diagnosis and therapy |
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| creator | Wasiluk, Alicja Mantur, Maria Szczepański, Marek Matowicka-Karna, Joanna Kemona, Halina Warda, Janusz |
| description | Objective: Does formation of platelet-derived microparticles correspond to platelet activation? Methods: The study was performed in 51 preterm newborns, 25 girls and 26 boys. The control group consisted of 55 term newborns, 25 girls and 30 boys. Blood samples were collected from the umbilical artery. The percentage of platelet-derived microparticles and platelet count were determined using flow cytometric analysis based on the CD61-positive antigen. Results: The percentage of platelet-derived microparticles was higher in preterm newborns (5.46) in comparison to term newborns (4.22, p < 0.01). We found 4.61% of platelet-derived microparticles in preterm female newborns and 6.28% in preterm boys (p < 0.0070). The platelet count was 256 × 10 3 µl in girls and 238 × 10 3 µl in boys. Female healthy term newborns presented higher values of platelet-derived microparticles (4.4%) than male newborns (4.07%, p = 0.4725, table 1). The platelet count in girls was found to be 308 × 10 3 µl and in boys 270 × 10 3 µl. Conclusions: Higher percentage of platelet-derived microparticles in preterm newborns may provide a compensatory mechanism for the hemostatic system. |
| doi_str_mv | 10.1159/000111597 |
| format | Article |
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Methods: The study was performed in 51 preterm newborns, 25 girls and 26 boys. The control group consisted of 55 term newborns, 25 girls and 30 boys. Blood samples were collected from the umbilical artery. The percentage of platelet-derived microparticles and platelet count were determined using flow cytometric analysis based on the CD61-positive antigen. Results: The percentage of platelet-derived microparticles was higher in preterm newborns (5.46) in comparison to term newborns (4.22, p < 0.01). We found 4.61% of platelet-derived microparticles in preterm female newborns and 6.28% in preterm boys (p < 0.0070). The platelet count was 256 × 10 3 µl in girls and 238 × 10 3 µl in boys. Female healthy term newborns presented higher values of platelet-derived microparticles (4.4%) than male newborns (4.07%, p = 0.4725, table 1). The platelet count in girls was found to be 308 × 10 3 µl and in boys 270 × 10 3 µl. Conclusions: Higher percentage of platelet-derived microparticles in preterm newborns may provide a compensatory mechanism for the hemostatic system.</description><identifier>ISSN: 1015-3837</identifier><identifier>EISSN: 1421-9964</identifier><identifier>DOI: 10.1159/000111597</identifier><identifier>PMID: 18046075</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Biological and medical sciences ; Cell Separation - methods ; Delivery. Postpartum. Lactation ; Diseases of mother, fetus and pregnancy ; Female ; Flow Cytometry - methods ; General aspects ; Gynecology. Andrology. Obstetrics ; Humans ; Infant, Newborn ; Infant, Premature - blood ; Infant, Premature - physiology ; Male ; Medical sciences ; Platelet Activation - physiology ; Platelet Count - methods ; Pregnancy. Fetus. Placenta</subject><ispartof>Fetal diagnosis and therapy, 2008-01, Vol.23 (2), p.149-152</ispartof><rights>2007 S. Karger AG, Basel</rights><rights>2008 INIST-CNRS</rights><rights>Copyright 2007 S. Karger AG, Basel.</rights><rights>Copyright (c) 2008 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-7e479d8d77099e981e6e29f36137f006c25e00e92af6581df7039d28cf0cc9e43</citedby><cites>FETCH-LOGICAL-c361t-7e479d8d77099e981e6e29f36137f006c25e00e92af6581df7039d28cf0cc9e43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20113470$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18046075$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wasiluk, Alicja</creatorcontrib><creatorcontrib>Mantur, Maria</creatorcontrib><creatorcontrib>Szczepański, Marek</creatorcontrib><creatorcontrib>Matowicka-Karna, Joanna</creatorcontrib><creatorcontrib>Kemona, Halina</creatorcontrib><creatorcontrib>Warda, Janusz</creatorcontrib><title>Platelet-Derived Microparticles and Platelet Count in Preterm Newborns</title><title>Fetal diagnosis and therapy</title><addtitle>Fetal Diagn Ther</addtitle><description>Objective: Does formation of platelet-derived microparticles correspond to platelet activation? Methods: The study was performed in 51 preterm newborns, 25 girls and 26 boys. The control group consisted of 55 term newborns, 25 girls and 30 boys. Blood samples were collected from the umbilical artery. The percentage of platelet-derived microparticles and platelet count were determined using flow cytometric analysis based on the CD61-positive antigen. Results: The percentage of platelet-derived microparticles was higher in preterm newborns (5.46) in comparison to term newborns (4.22, p < 0.01). We found 4.61% of platelet-derived microparticles in preterm female newborns and 6.28% in preterm boys (p < 0.0070). The platelet count was 256 × 10 3 µl in girls and 238 × 10 3 µl in boys. Female healthy term newborns presented higher values of platelet-derived microparticles (4.4%) than male newborns (4.07%, p = 0.4725, table 1). The platelet count in girls was found to be 308 × 10 3 µl and in boys 270 × 10 3 µl. Conclusions: Higher percentage of platelet-derived microparticles in preterm newborns may provide a compensatory mechanism for the hemostatic system.</description><subject>Biological and medical sciences</subject><subject>Cell Separation - methods</subject><subject>Delivery. Postpartum. Lactation</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Female</subject><subject>Flow Cytometry - methods</subject><subject>General aspects</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infant, Premature - blood</subject><subject>Infant, Premature - physiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Platelet Activation - physiology</subject><subject>Platelet Count - methods</subject><subject>Pregnancy. Fetus. 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Postpartum. Lactation</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Female</topic><topic>Flow Cytometry - methods</topic><topic>General aspects</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infant, Premature - blood</topic><topic>Infant, Premature - physiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Platelet Activation - physiology</topic><topic>Platelet Count - methods</topic><topic>Pregnancy. Fetus. Placenta</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wasiluk, Alicja</creatorcontrib><creatorcontrib>Mantur, Maria</creatorcontrib><creatorcontrib>Szczepański, Marek</creatorcontrib><creatorcontrib>Matowicka-Karna, Joanna</creatorcontrib><creatorcontrib>Kemona, Halina</creatorcontrib><creatorcontrib>Warda, Janusz</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Fetal diagnosis and therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wasiluk, Alicja</au><au>Mantur, Maria</au><au>Szczepański, Marek</au><au>Matowicka-Karna, Joanna</au><au>Kemona, Halina</au><au>Warda, Janusz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Platelet-Derived Microparticles and Platelet Count in Preterm Newborns</atitle><jtitle>Fetal diagnosis and therapy</jtitle><addtitle>Fetal Diagn Ther</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>23</volume><issue>2</issue><spage>149</spage><epage>152</epage><pages>149-152</pages><issn>1015-3837</issn><eissn>1421-9964</eissn><abstract>Objective: Does formation of platelet-derived microparticles correspond to platelet activation? Methods: The study was performed in 51 preterm newborns, 25 girls and 26 boys. The control group consisted of 55 term newborns, 25 girls and 30 boys. Blood samples were collected from the umbilical artery. The percentage of platelet-derived microparticles and platelet count were determined using flow cytometric analysis based on the CD61-positive antigen. Results: The percentage of platelet-derived microparticles was higher in preterm newborns (5.46) in comparison to term newborns (4.22, p < 0.01). We found 4.61% of platelet-derived microparticles in preterm female newborns and 6.28% in preterm boys (p < 0.0070). The platelet count was 256 × 10 3 µl in girls and 238 × 10 3 µl in boys. Female healthy term newborns presented higher values of platelet-derived microparticles (4.4%) than male newborns (4.07%, p = 0.4725, table 1). The platelet count in girls was found to be 308 × 10 3 µl and in boys 270 × 10 3 µl. Conclusions: Higher percentage of platelet-derived microparticles in preterm newborns may provide a compensatory mechanism for the hemostatic system.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>18046075</pmid><doi>10.1159/000111597</doi><tpages>4</tpages></addata></record> |
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| ispartof | Fetal diagnosis and therapy, 2008-01, Vol.23 (2), p.149-152 |
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| source | Karger Journal Archive Collection; Karger Journals; MEDLINE; Alma/SFX Local Collection |
| subjects | Biological and medical sciences Cell Separation - methods Delivery. Postpartum. Lactation Diseases of mother, fetus and pregnancy Female Flow Cytometry - methods General aspects Gynecology. Andrology. Obstetrics Humans Infant, Newborn Infant, Premature - blood Infant, Premature - physiology Male Medical sciences Platelet Activation - physiology Platelet Count - methods Pregnancy. Fetus. Placenta |
| title | Platelet-Derived Microparticles and Platelet Count in Preterm Newborns |
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