Actions of 3-methyl- N-oleoyldopamine, 4-methyl- N-oleoyldopamine and N-oleoylethanolamide on the rat TRPV1 receptor in vitro and in vivo

N-oleoyldopamine (OLDA) has been identified as an agonist of the transient receptor potential vanilloid type 1 (TRPV1) receptor. A related fatty acid amide, N-oleoylethanolamide (OEA), was found to excite sensory neurons and produce visceral hyperalgesia via activation of the TRPV1 receptor, however...

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Veröffentlicht in:	Life sciences (1973) 2008-03, Vol.82 (11), p.644-651
Hauptverfasser:	Almási, Róbert, Szőke, Éva, Bölcskei, Kata, Varga, Angelika, Riedl, Zsuzsanna, Sándor, Zoltán, Szolcsányi, János, Pethő, Gábor
Format:	Artikel
Sprache:	eng
Schlagworte:	3-methyl- N-oleoyldopamine 4-methyl- N-oleoyldopamine 45Ca 2+ uptake anandamide Animals Ca 2+ imaging Calcium - metabolism Calcium Radioisotopes - metabolism Capsaicin - metabolism Cells, Cultured Dopamine - analogs & derivatives Dopamine - chemistry Dopamine - genetics Dopamine - metabolism Endocannabinoids Increasing-temperature (incremental) hot plate Molecular Structure N-oleoylethanolamide Neurons - cytology Neurons - metabolism Oleic Acids - chemistry Oleic Acids - genetics Oleic Acids - metabolism Rats Sensory System Agents - metabolism Trigeminal Ganglion - cytology TRPV Cation Channels - agonists TRPV Cation Channels - antagonists & inhibitors TRPV Cation Channels - metabolism TRPV1 receptor
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