Toll like receptor-9 agonists stimulate prostate cancer invasion in vitro

BACKGROUND Toll‐like receptor 9 (TLR9) recognizes microbial DNA. In addition to immune cells, TLR9 expression has been detected in various cancer cells. We showed recently that TLR9 agonistic CpG‐oligonucleotides (CpG‐ODNs) induce matrix metalloproteinase‐13 (MMP‐13)‐mediated invasion in TLR9‐expres...

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Veröffentlicht in:	The Prostate 2007-05, Vol.67 (7), p.774-781
Hauptverfasser:	Ilvesaro, Joanna M., Merrell, Melinda A., Swain, Telisha Millender, Davidson, Jennifer, Zayzafoon, Majd, Harris, Kevin W., Selander, Katri S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - pharmacology Antimalarials - pharmacology Biological and medical sciences Cell Line, Tumor Chloroquine - pharmacology DNA, Bacterial - pharmacology Estradiol - pharmacology Gene Expression Regulation, Leukemic - drug effects Gynecology. Andrology. Obstetrics Humans Infection - complications invasion Male Male genital diseases Matrix Metalloproteinase 13 - genetics Matrix Metalloproteinase 13 - physiology matrix metalloproteinase-13 Medical sciences Neoplasm Invasiveness Nephrology. Urinary tract diseases Oligodeoxyribonucleotides - pharmacology prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Toll-like receptor 9 Toll-Like Receptor 9 - agonists Toll-Like Receptor 9 - genetics Toll-Like Receptor 9 - physiology Tumors Tumors of the urinary system Urinary tract. Prostate gland
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