Molecular profiling techniques and bioinformatics in cancer research
Abstract Aims Our aim was to describe the commonly used molecular profiling techniques in cancer research, to examine their limitations and to discuss the challenges of bioinformatics. Methods A literature search was performed using the PubMed database to identify publications relevant to this revie...
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| Veröffentlicht in: | European journal of surgical oncology 2007-04, Vol.33 (3), p.255-265 |
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| container_title | European journal of surgical oncology |
| container_volume | 33 |
| creator | Manning, A.T Garvin, J.T Shahbazi, R.I Miller, N McNeill, R.E Kerin, M.J |
| description | Abstract Aims Our aim was to describe the commonly used molecular profiling techniques in cancer research, to examine their limitations and to discuss the challenges of bioinformatics. Methods A literature search was performed using the PubMed database to identify publications relevant to this review. Citations from these articles were also examined to yield further relevant publications. Results We describe the use of DNA microarrays, comparative genomic hybridisation, tissue microarrays and digital differential display. The limitations of these technologies, their contribution to cancer research and the challenges of bioinformatics are also discussed. Conclusions Although these high throughput technologies each have their own limitations they are rapidly developing and contributing significantly to our understanding of cancer genetics. They have also led to the emergence of bioinformatics as a rapidly developing and vital field. |
| doi_str_mv | 10.1016/j.ejso.2006.09.002 |
| format | Article |
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Methods A literature search was performed using the PubMed database to identify publications relevant to this review. Citations from these articles were also examined to yield further relevant publications. Results We describe the use of DNA microarrays, comparative genomic hybridisation, tissue microarrays and digital differential display. The limitations of these technologies, their contribution to cancer research and the challenges of bioinformatics are also discussed. Conclusions Although these high throughput technologies each have their own limitations they are rapidly developing and contributing significantly to our understanding of cancer genetics. They have also led to the emergence of bioinformatics as a rapidly developing and vital field.</description><identifier>ISSN: 0748-7983</identifier><identifier>EISSN: 1532-2157</identifier><identifier>DOI: 10.1016/j.ejso.2006.09.002</identifier><identifier>PMID: 17071042</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Bioinformatics ; Biomarkers, Tumor - analysis ; Comparative genomic hybridisation ; Computational Biology - methods ; Digital differential display ; DNA, Neoplasm - analysis ; DNA-microarrays ; Gene Expression Profiling - methods ; Hematology, Oncology and Palliative Medicine ; Humans ; Microarray Analysis - methods ; Molecular profiling ; Neoplasms - genetics ; Surgery ; Tissue microarrays</subject><ispartof>European journal of surgical oncology, 2007-04, Vol.33 (3), p.255-265</ispartof><rights>Elsevier Ltd</rights><rights>2006 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-c18bc01391eb8fdcf49fc65f20694c523d7c544dd25d6a5ef60bf12e52474e203</citedby><cites>FETCH-LOGICAL-c409t-c18bc01391eb8fdcf49fc65f20694c523d7c544dd25d6a5ef60bf12e52474e203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejso.2006.09.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17071042$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Manning, A.T</creatorcontrib><creatorcontrib>Garvin, J.T</creatorcontrib><creatorcontrib>Shahbazi, R.I</creatorcontrib><creatorcontrib>Miller, N</creatorcontrib><creatorcontrib>McNeill, R.E</creatorcontrib><creatorcontrib>Kerin, M.J</creatorcontrib><title>Molecular profiling techniques and bioinformatics in cancer research</title><title>European journal of surgical oncology</title><addtitle>Eur J Surg Oncol</addtitle><description>Abstract Aims Our aim was to describe the commonly used molecular profiling techniques in cancer research, to examine their limitations and to discuss the challenges of bioinformatics. Methods A literature search was performed using the PubMed database to identify publications relevant to this review. Citations from these articles were also examined to yield further relevant publications. Results We describe the use of DNA microarrays, comparative genomic hybridisation, tissue microarrays and digital differential display. The limitations of these technologies, their contribution to cancer research and the challenges of bioinformatics are also discussed. Conclusions Although these high throughput technologies each have their own limitations they are rapidly developing and contributing significantly to our understanding of cancer genetics. 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| identifier | ISSN: 0748-7983 |
| ispartof | European journal of surgical oncology, 2007-04, Vol.33 (3), p.255-265 |
| issn | 0748-7983 1532-2157 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Bioinformatics Biomarkers, Tumor - analysis Comparative genomic hybridisation Computational Biology - methods Digital differential display DNA, Neoplasm - analysis DNA-microarrays Gene Expression Profiling - methods Hematology, Oncology and Palliative Medicine Humans Microarray Analysis - methods Molecular profiling Neoplasms - genetics Surgery Tissue microarrays |
| title | Molecular profiling techniques and bioinformatics in cancer research |
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