Mold Allergen, Pen c 13, Induces IL-8 Expression in Human Airway Epithelial Cells by Activating Protease-Activated Receptor 1 and 2

Allergenic serine proteases are important in the pathogenesis of asthma. One of these, Pen c 13, is the immunodominant allergen produced by Penicillium citrinum. Many serine proteases induce cytokine expression, but whether Pen c 13 does so in human respiratory epithelial cells is not known. In this...

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Veröffentlicht in:	Journal of Immunology 2007-04, Vol.178 (8), p.5237-5244
Hauptverfasser:	Chiu, Li-Li, Perng, Diahn-Warng, Yu, Chia-Hsien, Su, Song-Nan, Chow, Lu-Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergens - pharmacology Calcium - metabolism Cells, Cultured Epithelial Cells - immunology Extracellular Signal-Regulated MAP Kinases - metabolism Humans Interleukin-8 - biosynthesis Lung - immunology Penicillium - immunology Penicillium citrinum Phosphorylation Protease Inhibitors - pharmacology Receptor, PAR-1 - physiology Receptor, PAR-2 - physiology Type C Phospholipases - physiology
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