Bone healing in critical-size defects treated with platelet-rich plasma: a histologic and histometric study in rat calvaria
Background and Objective: The purpose of this study was to analyze histologically the influence of autologous platelet‐rich plasma on bone healing in surgically created critical‐size defects in rat calvaria. Material and Methods: Thirty‐two rats were divided into two groups: the control group (gro...
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| Veröffentlicht in: | Journal of periodontal research 2008-04, Vol.43 (2), p.217-223 |
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| creator | Messora, M. R. Nagata, M. J. H. Mariano, R. C. Dornelles, R. C. M. Bomfim, S. R. M. Fucini, S. E. Garcia, V. G. Bosco, A. F. |
| description | Background and Objective: The purpose of this study was to analyze histologically the influence of autologous platelet‐rich plasma on bone healing in surgically created critical‐size defects in rat calvaria.
Material and Methods: Thirty‐two rats were divided into two groups: the control group (group C) and the platelet‐rich plasma group. An 8‐mm‐diameter critical‐size defect was created in the calvarium of each animal. In group C the defect was filled by a blood clot only. In the platelet‐rich plasma group, 0.35 mL of platelet‐rich plasma was placed in the defect and covered by 0.35 mL of platelet‐poor plasma. Both groups were divided into subgroups (n = 8) and killed at either 4 or 12 wk postoperatively. Histometric (using image‐analysis software) and histologic analyses were performed. The amount of new bone formed was calculated as a percentage of the total area of the original defect. Percentage data were transformed into arccosine for statistical analysis (analysis of variance, Tukey, p |
| doi_str_mv | 10.1111/j.1600-0765.2007.01017.x |
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Material and Methods: Thirty‐two rats were divided into two groups: the control group (group C) and the platelet‐rich plasma group. An 8‐mm‐diameter critical‐size defect was created in the calvarium of each animal. In group C the defect was filled by a blood clot only. In the platelet‐rich plasma group, 0.35 mL of platelet‐rich plasma was placed in the defect and covered by 0.35 mL of platelet‐poor plasma. Both groups were divided into subgroups (n = 8) and killed at either 4 or 12 wk postoperatively. Histometric (using image‐analysis software) and histologic analyses were performed. The amount of new bone formed was calculated as a percentage of the total area of the original defect. Percentage data were transformed into arccosine for statistical analysis (analysis of variance, Tukey, p < 0.05).
Results: No defect completely regenerated with bone. The platelet‐rich plasma group had a statistically greater amount of bone formation than group C at both 4 wk (17.68% vs. 7.20%, respectively) and 12 wk (24.69% vs. 11.65%, respectively) postoperatively.
Conclusion: Within the limits of this study, it can be concluded that platelet‐rich plasma placed in the defects and covered by platelet‐poor plasma significantly enhanced bone healing in critical‐size defects in rat calvaria.</description><identifier>ISSN: 0022-3484</identifier><identifier>EISSN: 1600-0765</identifier><identifier>DOI: 10.1111/j.1600-0765.2007.01017.x</identifier><identifier>PMID: 18302625</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Analysis of Variance ; Animals ; Biological and medical sciences ; Bone Regeneration ; Dentistry ; growth factors ; Image Processing, Computer-Assisted ; in vivo model ; Male ; Medical sciences ; Otorhinolaryngology. Stomatology ; Platelet Count ; Platelet-Rich Plasma ; platelets ; Random Allocation ; Rats ; Skull - surgery</subject><ispartof>Journal of periodontal research, 2008-04, Vol.43 (2), p.217-223</ispartof><rights>2007 The Authors</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4357-5c503d6b3d566032a66ea05d56475859187b57fd3bcc041032da44c90f9cbe93</citedby><cites>FETCH-LOGICAL-c4357-5c503d6b3d566032a66ea05d56475859187b57fd3bcc041032da44c90f9cbe93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0765.2007.01017.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0765.2007.01017.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20161430$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18302625$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Messora, M. R.</creatorcontrib><creatorcontrib>Nagata, M. J. H.</creatorcontrib><creatorcontrib>Mariano, R. C.</creatorcontrib><creatorcontrib>Dornelles, R. C. M.</creatorcontrib><creatorcontrib>Bomfim, S. R. M.</creatorcontrib><creatorcontrib>Fucini, S. E.</creatorcontrib><creatorcontrib>Garcia, V. G.</creatorcontrib><creatorcontrib>Bosco, A. F.</creatorcontrib><title>Bone healing in critical-size defects treated with platelet-rich plasma: a histologic and histometric study in rat calvaria</title><title>Journal of periodontal research</title><addtitle>J Periodontal Res</addtitle><description>Background and Objective: The purpose of this study was to analyze histologically the influence of autologous platelet‐rich plasma on bone healing in surgically created critical‐size defects in rat calvaria.
Material and Methods: Thirty‐two rats were divided into two groups: the control group (group C) and the platelet‐rich plasma group. An 8‐mm‐diameter critical‐size defect was created in the calvarium of each animal. In group C the defect was filled by a blood clot only. In the platelet‐rich plasma group, 0.35 mL of platelet‐rich plasma was placed in the defect and covered by 0.35 mL of platelet‐poor plasma. Both groups were divided into subgroups (n = 8) and killed at either 4 or 12 wk postoperatively. Histometric (using image‐analysis software) and histologic analyses were performed. The amount of new bone formed was calculated as a percentage of the total area of the original defect. Percentage data were transformed into arccosine for statistical analysis (analysis of variance, Tukey, p < 0.05).
Results: No defect completely regenerated with bone. The platelet‐rich plasma group had a statistically greater amount of bone formation than group C at both 4 wk (17.68% vs. 7.20%, respectively) and 12 wk (24.69% vs. 11.65%, respectively) postoperatively.
Conclusion: Within the limits of this study, it can be concluded that platelet‐rich plasma placed in the defects and covered by platelet‐poor plasma significantly enhanced bone healing in critical‐size defects in rat calvaria.</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bone Regeneration</subject><subject>Dentistry</subject><subject>growth factors</subject><subject>Image Processing, Computer-Assisted</subject><subject>in vivo model</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Platelet Count</subject><subject>Platelet-Rich Plasma</subject><subject>platelets</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Skull - surgery</subject><issn>0022-3484</issn><issn>1600-0765</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtv1DAUhS0EokPhLyBvYJdwHb8SJBZQlfKoilRVqtSN5ThOx0MeU9tDZ9o_j9OMhi3e-B75O8f2QQgTyElaH1Y5EQAZSMHzAkDmQIDIfPsMLQ4Hz9ECoCgyykp2hF6FsIKkhaxeoiNS0jQWfIEev4yDxUurOzfcYjdg4110RndZcA8WN7a1JgYcvdXRNvjexSVed2nubMy8M08q9Poj1njpQhy78dYZrIdmlr2NicIhbprdFO91xCn9j_ZOv0YvWt0F-2a_H6Orr6dXJ9-y819n308-n2eGUS4zbjjQRtS04UIALbQQVgNPikle8oqUsuaybWhtDDCSiEYzZipoK1Pbih6j93Ps2o93Gxui6l0wtuv0YMdNUBIorWjFEljOoPFjCN62au1dr_1OEVBT72qlpnrVVK-aeldPvattsr7d37Gpe9v8M-6LTsC7PaBD-n_r9WBcOHAFEEEYhcR9mrl719ndfz9A_bg8nabkz2Z_Kt9uD37tfyshqeTq-uJM0eubS3FDL9RP-hdk5q4Z</recordid><startdate>200804</startdate><enddate>200804</enddate><creator>Messora, M. R.</creator><creator>Nagata, M. J. H.</creator><creator>Mariano, R. C.</creator><creator>Dornelles, R. C. M.</creator><creator>Bomfim, S. R. M.</creator><creator>Fucini, S. E.</creator><creator>Garcia, V. G.</creator><creator>Bosco, A. F.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200804</creationdate><title>Bone healing in critical-size defects treated with platelet-rich plasma: a histologic and histometric study in rat calvaria</title><author>Messora, M. R. ; Nagata, M. J. H. ; Mariano, R. C. ; Dornelles, R. C. M. ; Bomfim, S. R. M. ; Fucini, S. E. ; Garcia, V. G. ; Bosco, A. F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4357-5c503d6b3d566032a66ea05d56475859187b57fd3bcc041032da44c90f9cbe93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bone Regeneration</topic><topic>Dentistry</topic><topic>growth factors</topic><topic>Image Processing, Computer-Assisted</topic><topic>in vivo model</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Platelet Count</topic><topic>Platelet-Rich Plasma</topic><topic>platelets</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Skull - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Messora, M. R.</creatorcontrib><creatorcontrib>Nagata, M. J. H.</creatorcontrib><creatorcontrib>Mariano, R. C.</creatorcontrib><creatorcontrib>Dornelles, R. C. M.</creatorcontrib><creatorcontrib>Bomfim, S. R. M.</creatorcontrib><creatorcontrib>Fucini, S. E.</creatorcontrib><creatorcontrib>Garcia, V. G.</creatorcontrib><creatorcontrib>Bosco, A. F.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of periodontal research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Messora, M. R.</au><au>Nagata, M. J. H.</au><au>Mariano, R. C.</au><au>Dornelles, R. C. M.</au><au>Bomfim, S. R. M.</au><au>Fucini, S. E.</au><au>Garcia, V. G.</au><au>Bosco, A. F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone healing in critical-size defects treated with platelet-rich plasma: a histologic and histometric study in rat calvaria</atitle><jtitle>Journal of periodontal research</jtitle><addtitle>J Periodontal Res</addtitle><date>2008-04</date><risdate>2008</risdate><volume>43</volume><issue>2</issue><spage>217</spage><epage>223</epage><pages>217-223</pages><issn>0022-3484</issn><eissn>1600-0765</eissn><abstract>Background and Objective: The purpose of this study was to analyze histologically the influence of autologous platelet‐rich plasma on bone healing in surgically created critical‐size defects in rat calvaria.
Material and Methods: Thirty‐two rats were divided into two groups: the control group (group C) and the platelet‐rich plasma group. An 8‐mm‐diameter critical‐size defect was created in the calvarium of each animal. In group C the defect was filled by a blood clot only. In the platelet‐rich plasma group, 0.35 mL of platelet‐rich plasma was placed in the defect and covered by 0.35 mL of platelet‐poor plasma. Both groups were divided into subgroups (n = 8) and killed at either 4 or 12 wk postoperatively. Histometric (using image‐analysis software) and histologic analyses were performed. The amount of new bone formed was calculated as a percentage of the total area of the original defect. Percentage data were transformed into arccosine for statistical analysis (analysis of variance, Tukey, p < 0.05).
Results: No defect completely regenerated with bone. The platelet‐rich plasma group had a statistically greater amount of bone formation than group C at both 4 wk (17.68% vs. 7.20%, respectively) and 12 wk (24.69% vs. 11.65%, respectively) postoperatively.
Conclusion: Within the limits of this study, it can be concluded that platelet‐rich plasma placed in the defects and covered by platelet‐poor plasma significantly enhanced bone healing in critical‐size defects in rat calvaria.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>18302625</pmid><doi>10.1111/j.1600-0765.2007.01017.x</doi><tpages>7</tpages></addata></record> |
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| subjects | Analysis of Variance Animals Biological and medical sciences Bone Regeneration Dentistry growth factors Image Processing, Computer-Assisted in vivo model Male Medical sciences Otorhinolaryngology. Stomatology Platelet Count Platelet-Rich Plasma platelets Random Allocation Rats Skull - surgery |
| title | Bone healing in critical-size defects treated with platelet-rich plasma: a histologic and histometric study in rat calvaria |
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