Classifying protein kinase structures guides use of ligand-selectivity profiles to predict inactive conformations: Structure of lck/imatinib complex

We report a clustering of public human protein kinase structures based on the conformations of two structural elements, the activation segment and the C‐helix, revealing three discrete clusters. One cluster includes kinases in catalytically active conformations. Each of the other clusters contains a...

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Veröffentlicht in:	Proteins, structure, function, and bioinformatics structure, function, and bioinformatics, 2008-03, Vol.70 (4), p.1451-1460
Hauptverfasser:	Jacobs, Marc D., Caron, Paul R., Hare, Brian J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzamides Classification Crystallography, X-Ray Gleevec Humans Imatinib Mesylate kinase inhibitor Ligands Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - chemistry Piperazines - chemistry Protein Binding Protein Conformation Protein Kinases - chemistry Protein Kinases - classification Pyrimidines - chemistry structural bioinformatics X-ray crystallography
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