Circumdatin I, a New Ultraviolet-A Protecting Benzodiazepine Alkaloid from a Marine Isolate of the Fungus Exophiala
A new ultraviolet-A (UV-A) protecting benzodiazepine alkaloid, circumdatin I ( 1 ), along with the previously described circumdatin C ( 2 ) and circumdatin G ( 3 ), have been isolated from the mycelium of a marine-derived fungus of the genus Exophiala . The structures of the three circumdatins were...
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| Veröffentlicht in: | Journal of antibiotics 2008-01, Vol.61 (1), p.40-42 |
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| container_title | Journal of antibiotics |
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| creator | Zhang, Dahai Yang, Xiudong Kang, Jung Sook Choi, Hong Dae Son, Byeng Wha |
| description | A new ultraviolet-A (UV-A) protecting benzodiazepine alkaloid, circumdatin I (
1
), along with the previously described circumdatin C (
2
) and circumdatin G (
3
), have been isolated from the mycelium of a marine-derived fungus of the genus
Exophiala
. The structures of the three circumdatins were assigned on the basis of physicochemical evidence. The absolute stereochemistry of
1
was determined by comparison of optical rotation and CD experiments with those of
2
and
3
. |
| doi_str_mv | 10.1038/ja.2008.108 |
| format | Article |
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1
), along with the previously described circumdatin C (
2
) and circumdatin G (
3
), have been isolated from the mycelium of a marine-derived fungus of the genus
Exophiala
. The structures of the three circumdatins were assigned on the basis of physicochemical evidence. The absolute stereochemistry of
1
was determined by comparison of optical rotation and CD experiments with those of
2
and
3
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1
), along with the previously described circumdatin C (
2
) and circumdatin G (
3
), have been isolated from the mycelium of a marine-derived fungus of the genus
Exophiala
. The structures of the three circumdatins were assigned on the basis of physicochemical evidence. The absolute stereochemistry of
1
was determined by comparison of optical rotation and CD experiments with those of
2
and
3
.</description><subject>Alkaloids - chemistry</subject><subject>Alkaloids - isolation & purification</subject><subject>Alkaloids - pharmacology</subject><subject>Bacteriology</subject><subject>Benzodiazepines - chemistry</subject><subject>Benzodiazepines - isolation & purification</subject><subject>Benzodiazepines - pharmacology</subject><subject>Benzodiazepinones - chemistry</subject><subject>Benzodiazepinones - isolation & purification</subject><subject>Benzodiazepinones - pharmacology</subject><subject>Biomedical and Life Sciences</subject><subject>Bioorganic Chemistry</subject><subject>Exophiala</subject><subject>Exophiala - chemistry</subject><subject>Exophiala - isolation & purification</subject><subject>Life Sciences</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Marine Biology</subject><subject>Medicinal Chemistry</subject><subject>Microbiology</subject><subject>Molecular Structure</subject><subject>Organic Chemistry</subject><subject>Radiation-Protective Agents - 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pharmacology</topic><topic>Ultraviolet Rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Dahai</creatorcontrib><creatorcontrib>Yang, Xiudong</creatorcontrib><creatorcontrib>Kang, Jung Sook</creatorcontrib><creatorcontrib>Choi, Hong Dae</creatorcontrib><creatorcontrib>Son, Byeng Wha</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>ASFA: Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Dahai</au><au>Yang, Xiudong</au><au>Kang, Jung Sook</au><au>Choi, Hong Dae</au><au>Son, Byeng Wha</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circumdatin I, a New Ultraviolet-A Protecting Benzodiazepine Alkaloid from a Marine Isolate of the Fungus Exophiala</atitle><jtitle>Journal of antibiotics</jtitle><stitle>J Antibiot</stitle><addtitle>J Antibiot (Tokyo)</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>61</volume><issue>1</issue><spage>40</spage><epage>42</epage><pages>40-42</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><abstract>A new ultraviolet-A (UV-A) protecting benzodiazepine alkaloid, circumdatin I (
1
), along with the previously described circumdatin C (
2
) and circumdatin G (
3
), have been isolated from the mycelium of a marine-derived fungus of the genus
Exophiala
. The structures of the three circumdatins were assigned on the basis of physicochemical evidence. The absolute stereochemistry of
1
was determined by comparison of optical rotation and CD experiments with those of
2
and
3
.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>18305359</pmid><doi>10.1038/ja.2008.108</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of antibiotics, 2008-01, Vol.61 (1), p.40-42 |
| issn | 0021-8820 1881-1469 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70338679 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Alkaloids - chemistry Alkaloids - isolation & purification Alkaloids - pharmacology Bacteriology Benzodiazepines - chemistry Benzodiazepines - isolation & purification Benzodiazepines - pharmacology Benzodiazepinones - chemistry Benzodiazepinones - isolation & purification Benzodiazepinones - pharmacology Biomedical and Life Sciences Bioorganic Chemistry Exophiala Exophiala - chemistry Exophiala - isolation & purification Life Sciences Magnetic Resonance Spectroscopy Marine Biology Medicinal Chemistry Microbiology Molecular Structure Organic Chemistry Radiation-Protective Agents - chemistry Radiation-Protective Agents - isolation & purification Radiation-Protective Agents - pharmacology Ultraviolet Rays |
| title | Circumdatin I, a New Ultraviolet-A Protecting Benzodiazepine Alkaloid from a Marine Isolate of the Fungus Exophiala |
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