CYP19A1 polymorphisms are associated with bone mineral density in Chinese men
Aromatase-dependent biosynthesis of estrogen plays an important role in maintenance of the male skeleton, and Cytochrome p450 aromatase is the key enzyme to catalyze the conversion of androgen precursors to estrogens. We investigated the association of polymorphisms in the CYP19A1 gene and bone mine...
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| Veröffentlicht in: | Human genetics 2007-05, Vol.121 (3-4), p.491-500 |
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| creator | XIUMEI HONG HSU, Yi-Hsiang TERWEDOW, Henry ARGUELLES, Lester M GENFU TANG XUE LIU SHANCHUN ZHANG XIN XU XIPING XU |
| description | Aromatase-dependent biosynthesis of estrogen plays an important role in maintenance of the male skeleton, and Cytochrome p450 aromatase is the key enzyme to catalyze the conversion of androgen precursors to estrogens. We investigated the association of polymorphisms in the CYP19A1 gene and bone mineral density in a Chinese cohort. 2392 extreme low femoral neck BMD cases or extreme high femoral neck BMD controls were selected from a population-based cohort and genotyped for eight SNPs in the CYP19A1 gene. Significant associations for rs17703883, rs12594287 and rs16964201 SNPs with BMD were found in men only. Men with TC/CC genotypes in the rs17703883 SNP had a 1.5 times higher risk of having extreme low femoral neck BMD (P = 0.003, empirical P value = 0.05), and decreased BMDs at total body (P = 0.004, empirical P value = 0.07) and total hip (P = 0.003, empirical P value = 0.05). Men carrying AA/AG genotypes in the rs12594287 SNP had a 30% reduced risk of having extreme low femoral neck BMD (P = 0.007, empirical P value = 0.12), and increased BMDs at total body (P = 0.0009, empirical P value = 0.018) and total hip (P = 0.001, empirical P value = 0.02). Men carrying TT/TC genotypes in the rs16964201 SNP had a 40% reduced risk of having extreme low femoral neck BMD (P = 0.005, empirical P value = 0.087), and increased BMDs at total body (P = 0.0001, empirical P value = 0.002) and total hip (P = 0.0006, empirical P value = 0.012). Haplotype analysis showed that the G-C-T-A-T haplotype was significantly related to higher BMD. Our finding suggests that genetic variations in the CYP19A1 gene are significantly associated with BMD at different skeletal sites in adult men, but not in women. |
| doi_str_mv | 10.1007/s00439-006-0303-1 |
| format | Article |
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We investigated the association of polymorphisms in the CYP19A1 gene and bone mineral density in a Chinese cohort. 2392 extreme low femoral neck BMD cases or extreme high femoral neck BMD controls were selected from a population-based cohort and genotyped for eight SNPs in the CYP19A1 gene. Significant associations for rs17703883, rs12594287 and rs16964201 SNPs with BMD were found in men only. Men with TC/CC genotypes in the rs17703883 SNP had a 1.5 times higher risk of having extreme low femoral neck BMD (P = 0.003, empirical P value = 0.05), and decreased BMDs at total body (P = 0.004, empirical P value = 0.07) and total hip (P = 0.003, empirical P value = 0.05). Men carrying AA/AG genotypes in the rs12594287 SNP had a 30% reduced risk of having extreme low femoral neck BMD (P = 0.007, empirical P value = 0.12), and increased BMDs at total body (P = 0.0009, empirical P value = 0.018) and total hip (P = 0.001, empirical P value = 0.02). Men carrying TT/TC genotypes in the rs16964201 SNP had a 40% reduced risk of having extreme low femoral neck BMD (P = 0.005, empirical P value = 0.087), and increased BMDs at total body (P = 0.0001, empirical P value = 0.002) and total hip (P = 0.0006, empirical P value = 0.012). Haplotype analysis showed that the G-C-T-A-T haplotype was significantly related to higher BMD. Our finding suggests that genetic variations in the CYP19A1 gene are significantly associated with BMD at different skeletal sites in adult men, but not in women.</description><identifier>ISSN: 0340-6717</identifier><identifier>EISSN: 1432-1203</identifier><identifier>DOI: 10.1007/s00439-006-0303-1</identifier><identifier>PMID: 17216495</identifier><identifier>CODEN: HUGEDQ</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adult ; Analysis ; Aromatase - genetics ; Asian Continental Ancestry Group - genetics ; Biological and medical sciences ; Bone Density ; Bones ; Case-Control Studies ; Classical genetics, quantitative genetics, hybrids ; Cohort Studies ; Density ; Enzymes ; Estrogen ; Female ; Femur Neck - chemistry ; Fundamental and applied biological sciences. Psychology ; Gene Frequency ; Genes ; Genetic aspects ; Genetics of eukaryotes. Biological and molecular evolution ; Genotype ; Human ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Single nucleotide polymorphisms</subject><ispartof>Human genetics, 2007-05, Vol.121 (3-4), p.491-500</ispartof><rights>2007 INIST-CNRS</rights><rights>COPYRIGHT 2007 Springer</rights><rights>Springer-Verlag 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c449t-68b49e0bee680686ec1135559dc7bbf2b6ec69b388d6c98bc290a40e9fbb7ead3</citedby><cites>FETCH-LOGICAL-c449t-68b49e0bee680686ec1135559dc7bbf2b6ec69b388d6c98bc290a40e9fbb7ead3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27915,27916</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18699669$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17216495$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>XIUMEI HONG</creatorcontrib><creatorcontrib>HSU, Yi-Hsiang</creatorcontrib><creatorcontrib>TERWEDOW, Henry</creatorcontrib><creatorcontrib>ARGUELLES, Lester M</creatorcontrib><creatorcontrib>GENFU TANG</creatorcontrib><creatorcontrib>XUE LIU</creatorcontrib><creatorcontrib>SHANCHUN ZHANG</creatorcontrib><creatorcontrib>XIN XU</creatorcontrib><creatorcontrib>XIPING XU</creatorcontrib><title>CYP19A1 polymorphisms are associated with bone mineral density in Chinese men</title><title>Human genetics</title><addtitle>Hum Genet</addtitle><description>Aromatase-dependent biosynthesis of estrogen plays an important role in maintenance of the male skeleton, and Cytochrome p450 aromatase is the key enzyme to catalyze the conversion of androgen precursors to estrogens. We investigated the association of polymorphisms in the CYP19A1 gene and bone mineral density in a Chinese cohort. 2392 extreme low femoral neck BMD cases or extreme high femoral neck BMD controls were selected from a population-based cohort and genotyped for eight SNPs in the CYP19A1 gene. Significant associations for rs17703883, rs12594287 and rs16964201 SNPs with BMD were found in men only. Men with TC/CC genotypes in the rs17703883 SNP had a 1.5 times higher risk of having extreme low femoral neck BMD (P = 0.003, empirical P value = 0.05), and decreased BMDs at total body (P = 0.004, empirical P value = 0.07) and total hip (P = 0.003, empirical P value = 0.05). Men carrying AA/AG genotypes in the rs12594287 SNP had a 30% reduced risk of having extreme low femoral neck BMD (P = 0.007, empirical P value = 0.12), and increased BMDs at total body (P = 0.0009, empirical P value = 0.018) and total hip (P = 0.001, empirical P value = 0.02). Men carrying TT/TC genotypes in the rs16964201 SNP had a 40% reduced risk of having extreme low femoral neck BMD (P = 0.005, empirical P value = 0.087), and increased BMDs at total body (P = 0.0001, empirical P value = 0.002) and total hip (P = 0.0006, empirical P value = 0.012). Haplotype analysis showed that the G-C-T-A-T haplotype was significantly related to higher BMD. Our finding suggests that genetic variations in the CYP19A1 gene are significantly associated with BMD at different skeletal sites in adult men, but not in women.</description><subject>Adult</subject><subject>Analysis</subject><subject>Aromatase - genetics</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Biological and medical sciences</subject><subject>Bone Density</subject><subject>Bones</subject><subject>Case-Control Studies</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>Cohort Studies</subject><subject>Density</subject><subject>Enzymes</subject><subject>Estrogen</subject><subject>Female</subject><subject>Femur Neck - chemistry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Frequency</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Genotype</subject><subject>Human</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Single nucleotide polymorphisms</subject><issn>0340-6717</issn><issn>1432-1203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0U2LFDEQBuAgiju7-gO8SKMoeGitdNLp5DgMri6sKH4cPIUkXb2TpTsZk250_r0ZZmBZL54ClaeKVF5CnlF4SwG6dxmAM1UDiBoYsJo-ICvKWVPTBthDsgLGoRYd7c7Iec63ALRVTfuYnNGuoYKrdkU-bX5-oWpNq10c91NMu63PU65MwsrkHJ03M_bVbz9vKxsDVpMPmMxY9Riyn_eVD9VmW2q5XGF4Qh4NZsz49HRekB-X779vPtbXnz9cbdbXteNczbWQlisEiygkCCnQUcratlW966wdGlsqQlkmZS-cktY1CgwHVIO1HZqeXZDXx7m7FH8tmGc9-exwHE3AuGTdAWOSNuq_kKryE1zyAl_8A2_jkkJZQje0bUF1vCno5RHdmBG1D0Ock3GHiXrdKcpbyYQs6s095WKY8c98Y5ac9dW3r_ctPVqXYs4JB71LfjJprynoQ8b6mLEuGetDxpqWnuenpy52wv6u4xRqAa9OwGRnxiGZ4Hy-c1IoJYRifwHoX6t0</recordid><startdate>20070501</startdate><enddate>20070501</enddate><creator>XIUMEI HONG</creator><creator>HSU, Yi-Hsiang</creator><creator>TERWEDOW, Henry</creator><creator>ARGUELLES, Lester M</creator><creator>GENFU TANG</creator><creator>XUE LIU</creator><creator>SHANCHUN ZHANG</creator><creator>XIN XU</creator><creator>XIPING XU</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20070501</creationdate><title>CYP19A1 polymorphisms are associated with bone mineral density in Chinese men</title><author>XIUMEI HONG ; HSU, Yi-Hsiang ; TERWEDOW, Henry ; ARGUELLES, Lester M ; GENFU TANG ; XUE LIU ; SHANCHUN ZHANG ; XIN XU ; XIPING XU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c449t-68b49e0bee680686ec1135559dc7bbf2b6ec69b388d6c98bc290a40e9fbb7ead3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Analysis</topic><topic>Aromatase - genetics</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Biological and medical sciences</topic><topic>Bone Density</topic><topic>Bones</topic><topic>Case-Control Studies</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>Cohort Studies</topic><topic>Density</topic><topic>Enzymes</topic><topic>Estrogen</topic><topic>Female</topic><topic>Femur Neck - chemistry</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Frequency</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Genotype</topic><topic>Human</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Single nucleotide polymorphisms</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>XIUMEI HONG</creatorcontrib><creatorcontrib>HSU, Yi-Hsiang</creatorcontrib><creatorcontrib>TERWEDOW, Henry</creatorcontrib><creatorcontrib>ARGUELLES, Lester M</creatorcontrib><creatorcontrib>GENFU TANG</creatorcontrib><creatorcontrib>XUE LIU</creatorcontrib><creatorcontrib>SHANCHUN ZHANG</creatorcontrib><creatorcontrib>XIN XU</creatorcontrib><creatorcontrib>XIPING XU</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Biological Science Journals</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Human genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>XIUMEI HONG</au><au>HSU, Yi-Hsiang</au><au>TERWEDOW, Henry</au><au>ARGUELLES, Lester M</au><au>GENFU TANG</au><au>XUE LIU</au><au>SHANCHUN ZHANG</au><au>XIN XU</au><au>XIPING XU</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CYP19A1 polymorphisms are associated with bone mineral density in Chinese men</atitle><jtitle>Human genetics</jtitle><addtitle>Hum Genet</addtitle><date>2007-05-01</date><risdate>2007</risdate><volume>121</volume><issue>3-4</issue><spage>491</spage><epage>500</epage><pages>491-500</pages><issn>0340-6717</issn><eissn>1432-1203</eissn><coden>HUGEDQ</coden><abstract>Aromatase-dependent biosynthesis of estrogen plays an important role in maintenance of the male skeleton, and Cytochrome p450 aromatase is the key enzyme to catalyze the conversion of androgen precursors to estrogens. We investigated the association of polymorphisms in the CYP19A1 gene and bone mineral density in a Chinese cohort. 2392 extreme low femoral neck BMD cases or extreme high femoral neck BMD controls were selected from a population-based cohort and genotyped for eight SNPs in the CYP19A1 gene. Significant associations for rs17703883, rs12594287 and rs16964201 SNPs with BMD were found in men only. Men with TC/CC genotypes in the rs17703883 SNP had a 1.5 times higher risk of having extreme low femoral neck BMD (P = 0.003, empirical P value = 0.05), and decreased BMDs at total body (P = 0.004, empirical P value = 0.07) and total hip (P = 0.003, empirical P value = 0.05). Men carrying AA/AG genotypes in the rs12594287 SNP had a 30% reduced risk of having extreme low femoral neck BMD (P = 0.007, empirical P value = 0.12), and increased BMDs at total body (P = 0.0009, empirical P value = 0.018) and total hip (P = 0.001, empirical P value = 0.02). Men carrying TT/TC genotypes in the rs16964201 SNP had a 40% reduced risk of having extreme low femoral neck BMD (P = 0.005, empirical P value = 0.087), and increased BMDs at total body (P = 0.0001, empirical P value = 0.002) and total hip (P = 0.0006, empirical P value = 0.012). Haplotype analysis showed that the G-C-T-A-T haplotype was significantly related to higher BMD. Our finding suggests that genetic variations in the CYP19A1 gene are significantly associated with BMD at different skeletal sites in adult men, but not in women.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><cop>New York, NY</cop><pub>Springer</pub><pmid>17216495</pmid><doi>10.1007/s00439-006-0303-1</doi><tpages>10</tpages></addata></record> |
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| subjects | Adult Analysis Aromatase - genetics Asian Continental Ancestry Group - genetics Biological and medical sciences Bone Density Bones Case-Control Studies Classical genetics, quantitative genetics, hybrids Cohort Studies Density Enzymes Estrogen Female Femur Neck - chemistry Fundamental and applied biological sciences. Psychology Gene Frequency Genes Genetic aspects Genetics of eukaryotes. Biological and molecular evolution Genotype Human Humans Male Middle Aged Polymorphism, Single Nucleotide Single nucleotide polymorphisms |
| title | CYP19A1 polymorphisms are associated with bone mineral density in Chinese men |
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