Concise enantioselective total syntheses of (+)-homochelidonine, (+)-chelamidine, (+)-chelidonine, (+)-chelamine and (+)-norchelidonine by a Pd II-catalyzed ring-opening strategy

New enantioselective syntheses of the B/C hexahydrobenzo[c]phenanthridine alkaloids (+)-homochelidonine, (+)-chelamidine, (+)-chelidonine, (+)-chelamine, and (+)-norchelidonine are described. Our rapid and convergent route to this class of natural products involved the development and application of...

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Veröffentlicht in:	Chemistry : a European journal 2008, Vol.14 (7), p.2112-2124
Hauptverfasser:	Fleming, Matthew J, McManus, Helen A, Rudolph, Alena, Chan, Walter H, Ruiz, Jérémy, Dockendorff, Chris, Lautens, Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzophenanthridines - chemical synthesis Benzophenanthridines - chemistry Berberine Alkaloids - chemical synthesis Berberine Alkaloids - chemistry Boronic Acids - chemistry Catalysis Molecular Conformation Organometallic Compounds - chemistry Palladium - chemistry Stereoisomerism
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