Chronic biochemical cholestasis in patients receiving home parenteral nutrition: prevalence and predisposing factors
Summary Background Chronic biochemical cholestasis has been shown to be associated with a fivefold increase in histologically advanced liver disease in patients receiving home parenteral nutrition. Aims To investigate prevalence of chronic biochemical cholestasis in home parenteral nutrition patie...
Gespeichert in:
| Veröffentlicht in: | Alimentary pharmacology & therapeutics 2008-04, Vol.27 (7), p.552-560 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 560 |
|---|---|
| container_issue | 7 |
| container_start_page | 552 |
| container_title | Alimentary pharmacology & therapeutics |
| container_volume | 27 |
| creator | LLOYD, D. A. J. ZABRON, A. A. GABE, S. M. |
| description | Summary
Background Chronic biochemical cholestasis has been shown to be associated with a fivefold increase in histologically advanced liver disease in patients receiving home parenteral nutrition.
Aims To investigate prevalence of chronic biochemical cholestasis in home parenteral nutrition patients and examine factors influencing its occurrence.
Methods Records of all patients receiving home parenteral nutrition for >6 months treated at a single centre were reviewed and plasma biochemistry recorded. Logistic regression analysis was employed to identify factors associated with prevalence of chronic biochemical cholestasis.
Results Records of 113 patients were reviewed. The point prevalence of chronic biochemical cholestasis was 24%, increasing to 28% if patients receiving parenteral fluid and electrolytes only were excluded. In multivariate analysis, presence of colon in continuity was associated with a significantly lower prevalence of chronic biochemical cholestasis, while total parenteral calorie intake was associated with a higher prevalence of chronic biochemical cholestasis. No association was seen between small intestinal lengths or between parenteral lipid intake and chronic biochemical cholestasis in multivariate analysis.
Conclusions Chronic biochemical cholestasis is common in patients receiving home parenteral nutrition. High parenteral calorie intake and lack of a colon in continuity with small intestine are independently associated with an increased risk of chronic biochemical cholestasis. |
| doi_str_mv | 10.1111/j.1365-2036.2008.03615.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70336151</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70336151</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3975-c16ed5623d57f9d39ccaf089817fdcbe0433393c0757b9534736ba5b5470dfd53</originalsourceid><addsrcrecordid>eNqNkE9PHCEYh0mjqavtV2i46G1GGIZhMOnBbFo1MdGDPRMG3umymYEpzFr99jLdjb3KhZeX58efByFMSUnzuNyWlDW8qAhryoqQtswF5eXLJ7R63zhCK1I1sqhayk7QaUpbQkgjSPUZndCWyrqWfIXm9SYG7wzuXDAbGJ3RAzabMECadXIJO48nPTvwc8IRDLhn53_jTRgh92NuQ8wJv5ujm13wV3iK8KwH8Aaw9nZZWpemkJZYr80cYvqCjns9JPh6mM_Qr58_nta3xf3Dzd36-r4wTApeGNqA5U3FLBe9tEwao3vSypaK3poOSM0Yk8wQwUUnOasFazrNO14LYnvL2Rm62J87xfBnl3-kRpcMDIP2EHZJCcIWbzSD7R40MaQUoVdTdKOOr4oStRhXW7WIVYtYtRhX_4yrlxz9drhj141g_wcPijNwfgB0ynL7qL1x6Z2rCG1a0laZ-77n_roBXj_8AHX9-LRU7A2Ir56c</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70336151</pqid></control><display><type>article</type><title>Chronic biochemical cholestasis in patients receiving home parenteral nutrition: prevalence and predisposing factors</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Wiley Free Content</source><creator>LLOYD, D. A. J. ; ZABRON, A. A. ; GABE, S. M.</creator><creatorcontrib>LLOYD, D. A. J. ; ZABRON, A. A. ; GABE, S. M.</creatorcontrib><description>Summary
Background Chronic biochemical cholestasis has been shown to be associated with a fivefold increase in histologically advanced liver disease in patients receiving home parenteral nutrition.
Aims To investigate prevalence of chronic biochemical cholestasis in home parenteral nutrition patients and examine factors influencing its occurrence.
Methods Records of all patients receiving home parenteral nutrition for >6 months treated at a single centre were reviewed and plasma biochemistry recorded. Logistic regression analysis was employed to identify factors associated with prevalence of chronic biochemical cholestasis.
Results Records of 113 patients were reviewed. The point prevalence of chronic biochemical cholestasis was 24%, increasing to 28% if patients receiving parenteral fluid and electrolytes only were excluded. In multivariate analysis, presence of colon in continuity was associated with a significantly lower prevalence of chronic biochemical cholestasis, while total parenteral calorie intake was associated with a higher prevalence of chronic biochemical cholestasis. No association was seen between small intestinal lengths or between parenteral lipid intake and chronic biochemical cholestasis in multivariate analysis.
Conclusions Chronic biochemical cholestasis is common in patients receiving home parenteral nutrition. High parenteral calorie intake and lack of a colon in continuity with small intestine are independently associated with an increased risk of chronic biochemical cholestasis.</description><identifier>ISSN: 0269-2813</identifier><identifier>EISSN: 1365-2036</identifier><identifier>DOI: 10.1111/j.1365-2036.2008.03615.x</identifier><identifier>PMID: 18194495</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Body Mass Index ; Cholestasis - enzymology ; Cholestasis - epidemiology ; Cholestasis - etiology ; Chronic Disease ; Digestive system ; Energy Intake ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical Records ; Medical sciences ; Middle Aged ; Other diseases. Semiology ; Parenteral Nutrition - adverse effects ; Pharmacology. Drug treatments ; Prevalence ; United Kingdom - epidemiology</subject><ispartof>Alimentary pharmacology & therapeutics, 2008-04, Vol.27 (7), p.552-560</ispartof><rights>2008 The Authors. Journal compilation © 2008 Blackwell Publishing Ltd</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3975-c16ed5623d57f9d39ccaf089817fdcbe0433393c0757b9534736ba5b5470dfd53</citedby><cites>FETCH-LOGICAL-c3975-c16ed5623d57f9d39ccaf089817fdcbe0433393c0757b9534736ba5b5470dfd53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2036.2008.03615.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2036.2008.03615.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27903,27904,45553,45554,46387,46811</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20168082$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18194495$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LLOYD, D. A. J.</creatorcontrib><creatorcontrib>ZABRON, A. A.</creatorcontrib><creatorcontrib>GABE, S. M.</creatorcontrib><title>Chronic biochemical cholestasis in patients receiving home parenteral nutrition: prevalence and predisposing factors</title><title>Alimentary pharmacology & therapeutics</title><addtitle>Aliment Pharmacol Ther</addtitle><description>Summary
Background Chronic biochemical cholestasis has been shown to be associated with a fivefold increase in histologically advanced liver disease in patients receiving home parenteral nutrition.
Aims To investigate prevalence of chronic biochemical cholestasis in home parenteral nutrition patients and examine factors influencing its occurrence.
Methods Records of all patients receiving home parenteral nutrition for >6 months treated at a single centre were reviewed and plasma biochemistry recorded. Logistic regression analysis was employed to identify factors associated with prevalence of chronic biochemical cholestasis.
Results Records of 113 patients were reviewed. The point prevalence of chronic biochemical cholestasis was 24%, increasing to 28% if patients receiving parenteral fluid and electrolytes only were excluded. In multivariate analysis, presence of colon in continuity was associated with a significantly lower prevalence of chronic biochemical cholestasis, while total parenteral calorie intake was associated with a higher prevalence of chronic biochemical cholestasis. No association was seen between small intestinal lengths or between parenteral lipid intake and chronic biochemical cholestasis in multivariate analysis.
Conclusions Chronic biochemical cholestasis is common in patients receiving home parenteral nutrition. High parenteral calorie intake and lack of a colon in continuity with small intestine are independently associated with an increased risk of chronic biochemical cholestasis.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>Cholestasis - enzymology</subject><subject>Cholestasis - epidemiology</subject><subject>Cholestasis - etiology</subject><subject>Chronic Disease</subject><subject>Digestive system</subject><subject>Energy Intake</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical Records</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Other diseases. Semiology</subject><subject>Parenteral Nutrition - adverse effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Prevalence</subject><subject>United Kingdom - epidemiology</subject><issn>0269-2813</issn><issn>1365-2036</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE9PHCEYh0mjqavtV2i46G1GGIZhMOnBbFo1MdGDPRMG3umymYEpzFr99jLdjb3KhZeX58efByFMSUnzuNyWlDW8qAhryoqQtswF5eXLJ7R63zhCK1I1sqhayk7QaUpbQkgjSPUZndCWyrqWfIXm9SYG7wzuXDAbGJ3RAzabMECadXIJO48nPTvwc8IRDLhn53_jTRgh92NuQ8wJv5ujm13wV3iK8KwH8Aaw9nZZWpemkJZYr80cYvqCjns9JPh6mM_Qr58_nta3xf3Dzd36-r4wTApeGNqA5U3FLBe9tEwao3vSypaK3poOSM0Yk8wQwUUnOasFazrNO14LYnvL2Rm62J87xfBnl3-kRpcMDIP2EHZJCcIWbzSD7R40MaQUoVdTdKOOr4oStRhXW7WIVYtYtRhX_4yrlxz9drhj141g_wcPijNwfgB0ynL7qL1x6Z2rCG1a0laZ-77n_roBXj_8AHX9-LRU7A2Ir56c</recordid><startdate>200804</startdate><enddate>200804</enddate><creator>LLOYD, D. A. J.</creator><creator>ZABRON, A. A.</creator><creator>GABE, S. M.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200804</creationdate><title>Chronic biochemical cholestasis in patients receiving home parenteral nutrition: prevalence and predisposing factors</title><author>LLOYD, D. A. J. ; ZABRON, A. A. ; GABE, S. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3975-c16ed5623d57f9d39ccaf089817fdcbe0433393c0757b9534736ba5b5470dfd53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>Cholestasis - enzymology</topic><topic>Cholestasis - epidemiology</topic><topic>Cholestasis - etiology</topic><topic>Chronic Disease</topic><topic>Digestive system</topic><topic>Energy Intake</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical Records</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Other diseases. Semiology</topic><topic>Parenteral Nutrition - adverse effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Prevalence</topic><topic>United Kingdom - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LLOYD, D. A. J.</creatorcontrib><creatorcontrib>ZABRON, A. A.</creatorcontrib><creatorcontrib>GABE, S. M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Alimentary pharmacology & therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LLOYD, D. A. J.</au><au>ZABRON, A. A.</au><au>GABE, S. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic biochemical cholestasis in patients receiving home parenteral nutrition: prevalence and predisposing factors</atitle><jtitle>Alimentary pharmacology & therapeutics</jtitle><addtitle>Aliment Pharmacol Ther</addtitle><date>2008-04</date><risdate>2008</risdate><volume>27</volume><issue>7</issue><spage>552</spage><epage>560</epage><pages>552-560</pages><issn>0269-2813</issn><eissn>1365-2036</eissn><abstract>Summary
Background Chronic biochemical cholestasis has been shown to be associated with a fivefold increase in histologically advanced liver disease in patients receiving home parenteral nutrition.
Aims To investigate prevalence of chronic biochemical cholestasis in home parenteral nutrition patients and examine factors influencing its occurrence.
Methods Records of all patients receiving home parenteral nutrition for >6 months treated at a single centre were reviewed and plasma biochemistry recorded. Logistic regression analysis was employed to identify factors associated with prevalence of chronic biochemical cholestasis.
Results Records of 113 patients were reviewed. The point prevalence of chronic biochemical cholestasis was 24%, increasing to 28% if patients receiving parenteral fluid and electrolytes only were excluded. In multivariate analysis, presence of colon in continuity was associated with a significantly lower prevalence of chronic biochemical cholestasis, while total parenteral calorie intake was associated with a higher prevalence of chronic biochemical cholestasis. No association was seen between small intestinal lengths or between parenteral lipid intake and chronic biochemical cholestasis in multivariate analysis.
Conclusions Chronic biochemical cholestasis is common in patients receiving home parenteral nutrition. High parenteral calorie intake and lack of a colon in continuity with small intestine are independently associated with an increased risk of chronic biochemical cholestasis.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>18194495</pmid><doi>10.1111/j.1365-2036.2008.03615.x</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0269-2813 |
| ispartof | Alimentary pharmacology & therapeutics, 2008-04, Vol.27 (7), p.552-560 |
| issn | 0269-2813 1365-2036 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70336151 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Free Content |
| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Body Mass Index Cholestasis - enzymology Cholestasis - epidemiology Cholestasis - etiology Chronic Disease Digestive system Energy Intake Female Gastroenterology. Liver. Pancreas. Abdomen Humans Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical Records Medical sciences Middle Aged Other diseases. Semiology Parenteral Nutrition - adverse effects Pharmacology. Drug treatments Prevalence United Kingdom - epidemiology |
| title | Chronic biochemical cholestasis in patients receiving home parenteral nutrition: prevalence and predisposing factors |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T15%3A28%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Chronic%20biochemical%20cholestasis%20in%20patients%20receiving%20home%20parenteral%20nutrition:%20prevalence%20and%20predisposing%20factors&rft.jtitle=Alimentary%20pharmacology%20&%20therapeutics&rft.au=LLOYD,%20D.%20A.%20J.&rft.date=2008-04&rft.volume=27&rft.issue=7&rft.spage=552&rft.epage=560&rft.pages=552-560&rft.issn=0269-2813&rft.eissn=1365-2036&rft_id=info:doi/10.1111/j.1365-2036.2008.03615.x&rft_dat=%3Cproquest_cross%3E70336151%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=70336151&rft_id=info:pmid/18194495&rfr_iscdi=true |