Biosynthesis of Wdr16, a marker protein for kinocilia-bearing cells, starts at the time of kinocilia formation in rat, and wdr16 gene knockdown causes hydrocephalus in zebrafish

The rat ortholog of the WD40 repeat protein Wdr16 is abundantly expressed in testis and cultured ependymal cells. Low levels are found in lung and brain, respectively, while it is absent from kinocilia-free tissues. In testis and ependymal primary cultures, Wdr16 messenger RNA appears concomitantly...

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Veröffentlicht in:	Journal of neurochemistry 2007-04, Vol.101 (1), p.274-288
Hauptverfasser:	Hirschner, Wolfgang, Pogoda, Hans-Martin, Kramer, Carina, Thiess, Ulrike, Hamprecht, Bernd, Wiesmüller, Karl-Heinz, Lautner, Matthias, Verleysdonk, Stephan
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence Biomarkers - analysis Biomarkers - metabolism cell polarity Cells, Cultured cellular differentiation Cilia - metabolism Ciliary Motility Disorders - genetics Ciliary Motility Disorders - metabolism Ciliary Motility Disorders - physiopathology Down-Regulation - drug effects Down-Regulation - physiology Ependyma - abnormalities Ependyma - cytology Ependyma - metabolism Evolution, Molecular Humans Hydrocephalus - genetics Hydrocephalus - metabolism Hydrocephalus - physiopathology Lateral Ventricles - abnormalities Lateral Ventricles - metabolism Lateral Ventricles - physiopathology Microfilament Proteins - biosynthesis Microfilament Proteins - genetics Microfilament Proteins - isolation & purification Molecular Sequence Data nerve tissue Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - genetics Nerve Tissue Proteins - isolation & purification Oligonucleotides, Antisense - pharmacology Phylogeny primary cell culture Rats RNA, Messenger - metabolism Sequence Homology, Amino Acid testes Water-Electrolyte Balance - genetics Water-Electrolyte Balance - physiology WD40 repeat protein Zebrafish - abnormalities Zebrafish Proteins - biosynthesis Zebrafish Proteins - genetics Zebrafish Proteins - isolation & purification
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