Activation of estrogen receptor-β regulates hippocampal synaptic plasticity and improves memory

Estrogens have long been implicated in influencing cognitive processes, yet the molecular mechanisms underlying these effects and the roles of the estrogen receptors alpha (ERα) and beta (ERβ) remain unclear. Using pharmacological, biochemical and behavioral techniques, we demonstrate that the effec...

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Veröffentlicht in:	Nature neuroscience 2008-03, Vol.11 (3), p.334-343
Hauptverfasser:	Liu, Feng, Day, Mark, Muñiz, Luis C, Bitran, Daniel, Arias, Robert, Revilla-Sanchez, Raquel, Grauer, Steve, Zhang, Guoming, Kelley, Cody, Pulito, Virginia, Sung, Amy, Mervis, Ronald F, Navarra, Rachel, Hirst, Warren D, Reinhart, Peter H, Marquis, Karen L, Moss, Stephen J, Pangalos, Menelas N, Brandon, Nicholas J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Genetics and Genomics Animals Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Cyclic AMP Response Element-Binding Protein - drug effects Cyclic AMP Response Element-Binding Protein - metabolism Dendritic Spines - drug effects Dendritic Spines - metabolism Estradiol - metabolism Estradiol - pharmacology Estrogen Estrogen Receptor beta - agonists Estrogen Receptor beta - genetics Estrogen Receptor beta - metabolism Estrogens - agonists Estrogens - metabolism Estrogens - pharmacology Female Hippocampus - cytology Hippocampus - drug effects Hippocampus - metabolism Long-Term Potentiation - drug effects Long-Term Potentiation - physiology Male Maze Learning - drug effects Maze Learning - physiology Memory Memory - drug effects Memory - physiology Mice Mice, Inbred C57BL Mice, Knockout Neurobiology Neuronal Plasticity - drug effects Neuronal Plasticity - physiology Neurons - cytology Neurons - drug effects Neurons - metabolism Neuroplasticity Neurosciences Organ Culture Techniques Ovariectomy Phosphorylation - drug effects Physiological aspects Rats Receptors Synaptic Transmission - drug effects Synaptic Transmission - physiology
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