Serum amyloid A-induced IL-6 production by rheumatoid synoviocytes

In this study, we investigated the role of serum amyloid A protein (SAA) in the production of interleukin-6 (IL-6) using rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS). Recombinant SAA stimulation induced the production of pro-inflammatory cytokine, IL-6, from RA-FLS. The signaling event...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	FEBS letters 2008-03, Vol.582 (5), p.579-585
Hauptverfasser:	Koga, Tomohiro, Torigoshi, Takafumi, Motokawa, Satoru, Miyashita, Taichiro, Maeda, Yumi, Nakamura, Minoru, Komori, Atsumasa, Aiba, Yoshihiro, Uemura, Takashi, Yatsuhashi, Hiroshi, Ishibashi, Hiromi, Eguchi, Katsumi, Migita, Kiyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Arthritis, Rheumatoid - enzymology Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - pathology DNA - metabolism fibroblast-like synoviocytes Fibroblasts - drug effects Fibroblasts - enzymology Fibroblasts - pathology FLS FPRL1 Gene Expression Regulation - drug effects Humans IL-6 Interleukin-6 Interleukin-6 - genetics Interleukin-6 - secretion JNK Mitogen-Activated Protein Kinases - metabolism MAPKs mitogen-activated protein kineases N-formyl peptide receptor-like 1 NF-kappa B - antagonists & inhibitors NF-κB Nuclear factor-kappa B p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation - drug effects Protein Binding - drug effects Receptors, Formyl Peptide - genetics Receptors, Formyl Peptide - metabolism Receptors, Lipoxin - genetics Receptors, Lipoxin - metabolism Rheumatoid arthritis RNA, Messenger - genetics RNA, Messenger - metabolism SAA Serum amyloid A protein Serum Amyloid A Protein - pharmacology Synovial Fluid - cytology Synovial Fluid - drug effects Synovial Fluid - enzymology Synovial Fluid - secretion Transcription Factor RelA - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!