Impaired acid secretion in cortical collecting duct intercalated cells from H-K-ATPase-deficient mice: role of HKalpha isoforms

Two classes of H pumps, H-K-ATPase and H-ATPase, contribute to luminal acidification and HCO(3) transport in the collecting duct (CD). At least two H-K-ATPase alpha-subunits are expressed in the CD: HKalpha(1) and HKalpha(2). Both exhibit K dependence but have different inhibitor sensitivities. The...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2008-03, Vol.294 (3), p.F621-F627
Hauptverfasser:	Lynch, I Jeanette, Rudin, Alicia, Xia, Shen-Ling, Stow, Lisa R, Shull, Gary E, Weiner, I David, Cain, Brian D, Wingo, Charles S
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids - metabolism Amiloride - analogs & derivatives Amiloride - pharmacology Animals Anti-Arrhythmia Agents - pharmacology Diet Female Genotype H(+)-K(+)-Exchanging ATPase - deficiency H(+)-K(+)-Exchanging ATPase - genetics Hydrogen-Ion Concentration - drug effects Kidney Tubules, Collecting - cytology Kidney Tubules, Collecting - metabolism Kidney Tubules, Collecting - secretion Macrolides - pharmacology Mice Mice, Inbred C57BL Mice, Knockout Protein Isoforms - metabolism Proton-Translocating ATPases - antagonists & inhibitors Protons
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