Dynamic stromal‐epithelial interactions during progression of MCF10DCIS.com xenografts

MCF10DCIS.com cells form comedo type ductal carcinoma in situ in immune‐deficient mice before forming invasive ductal carcinoma. As the lesions mature, both stromal and epithelial cells undergo phenotypic changes detected by immunohistochemistry. Myofibroblasts are present before the formation of ca...

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Veröffentlicht in:	International journal of cancer 2007-05, Vol.120 (10), p.2127-2134
Hauptverfasser:	Tait, Larry R., Pauley, Robert J., Santner, Steven J., Heppner, Gloria H., Heng, Henry H., Rak, Janusz W., Miller, Fred R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals breast cancer Breast Neoplasms - metabolism Breast Neoplasms - pathology carcinoma in situ Carcinoma, Ductal, Breast - metabolism Carcinoma, Ductal, Breast - pathology Carcinoma, Intraductal, Noninfiltrating - metabolism Carcinoma, Intraductal, Noninfiltrating - pathology Cell Communication - physiology Disease Progression Epithelial Cells - metabolism Epithelial Cells - pathology Female Humans Immunohistochemistry MCF10DCIS.com Mice Mice, Nude Mice, SCID progression Protein Biosynthesis Receptors, CXCR4 - biosynthesis stroma Stromal Cells - metabolism Stromal Cells - pathology Transforming Growth Factor beta1 - biosynthesis Transplantation, Heterologous xenograft
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