Sox18 and Sox7 play redundant roles in vascular development

Mutations in SOX18 cause the human hypotrichosis-lymphedema-telangiectasia (HLT) syndrome. Their murine counterparts are the spontaneous ragged mutants, showing combined defects in hair follicle, blood vessel, and lymphatic vessel development. Mice null for Sox18 display only mild coat defects, sugg...

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Veröffentlicht in:	Blood 2008-03, Vol.111 (5), p.2657-2666
Hauptverfasser:	Cermenati, Solei, Moleri, Silvia, Cimbro, Simona, Corti, Paola, Del Giacco, Luca, Amodeo, Roberta, Dejana, Elisabetta, Koopman, Peter, Cotelli, Franco, Beltrame, Monica
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Biomarkers - metabolism Blood Circulation Blood Vessels - abnormalities Blood Vessels - embryology DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Embryo, Nonmammalian - abnormalities Endothelial Cells - metabolism Gene Expression Regulation, Developmental Genes, Reporter Mutation - genetics Organ Specificity Sequence Homology, Amino Acid SOXF Transcription Factors Zebrafish - embryology Zebrafish - genetics Zebrafish Proteins - genetics Zebrafish Proteins - metabolism
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