Changes in enzyme activities at the pyruvate node in glutamate-overproducing Corynebacterium glutamicum

Glutamate is industrially produced by fermentation using Corynebacterium glutamicum. The key factor for efficient glutamate production by this microorganism has been considered to be a metabolic change at the 2-oxoglutarate dehydrogenase (ODH) branch point caused by a decrease in ODH activity under...

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Veröffentlicht in:	Journal of bioscience and bioengineering 2008, Vol.105 (1), p.12-19
Hauptverfasser:	Hasegawa, Takuo, Hashimoto, Ken-Ichi, Kawasaki, Hisashi, Nakamatsu, Tsuyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyl Coenzyme A - metabolism Bacterial Proteins - metabolism Biological and medical sciences Biotechnology Corynebacterium glutamicum Corynebacterium glutamicum - enzymology Down-Regulation Fundamental and applied biological sciences. Psychology glutamate overproduction Glutamic Acid - biosynthesis Industrial Microbiology metabolic change Oxaloacetic Acid - metabolism pyruvate pyruvate carboxylase Pyruvate Carboxylase - metabolism pyruvate dehydrogenase Pyruvate Dehydrogenase Complex - metabolism Pyruvic Acid - metabolism
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