Magnetic Resonance Imaging of the Thalamus and Adhesio Interthalamica in Twins With Schizophrenia
CONTEXT Abnormalities of the thalamus are thought to be central to the pathophysiology of schizophrenia. These abnormalities include altered structure and shape of the thalamus itself and possibly changes to the adhesio interthalamica (or massa intermedia), the gray matter bridge connecting the 2 th...
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| Veröffentlicht in: | Archives of general psychiatry 2007-04, Vol.64 (4), p.401-409 |
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| creator | Ettinger, Ulrich Picchioni, Marco Landau, Sabine Matsumoto, Kazunori van Haren, Neeltje E Marshall, Nicolette Hall, Mei-Hua Schulze, Katja Toulopoulou, Timothea Davies, Nadia Ribchester, Tracy McGuire, Philip K Murray, Robin M |
| description | CONTEXT Abnormalities of the thalamus are thought to be central to the pathophysiology of schizophrenia. These abnormalities include altered structure and shape of the thalamus itself and possibly changes to the adhesio interthalamica (or massa intermedia), the gray matter bridge connecting the 2 thalamic lobes. However, it is not clear to what extent these abnormalities are determined by the genetic liability for schizophrenia. OBJECTIVE To investigate thalamic volume and the presence of the adhesio interthalamica in monozygotic (MZ) twins concordant or discordant for schizophrenia. DESIGN Study of MZ twins. SETTING Patients were drawn from inpatient and outpatient clinics. Twin controls were recruited from a volunteer twin register and through media advertisements. PARTICIPANTS A total of 123 twins participated: 19 MZ twin pairs concordant for schizophrenia, 15 MZ schizophrenic twins and 16 MZ nonschizophrenic twins drawn from 17 pairs discordant for schizophrenia, and 27 MZ twin pairs without schizophrenia. Groups were matched for age, sex, handedness, level of education, parental socioeconomic status, and ethnicity. MAIN OUTCOME MEASURES The volume of the thalamus (including right and left hemispheres) was measured (in cubic centimeters) and the presence of the adhesio interthalamica was ascertained from structural magnetic resonance images. RESULTS Concordant twin pairs displayed significantly reduced thalamic volume compared with control twins, even when covarying for effects of whole-brain volume, age, and sex. There was a significant linear decrease in thalamic volume (control greater than discordant nonschizophrenic greater than discordant schizophrenic greater than concordant). In all groups, right thalamus was larger than left thalamus. There was no difference across groups in the frequency of the adhesio interthalamica. CONCLUSIONS Volumetric thalamic abnormalities in schizophrenia occur in twin pairs concordant for schizophrenia. These abnormalities may mark the substantial genetic contribution to the illness seen in concordant twin pairs, whereas the adhesio interthalamica is unlikely to be affected in schizophrenia.Arch Gen Psychiatry. 2007;64:401-409--> |
| doi_str_mv | 10.1001/archpsyc.64.4.401 |
| format | Article |
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These abnormalities include altered structure and shape of the thalamus itself and possibly changes to the adhesio interthalamica (or massa intermedia), the gray matter bridge connecting the 2 thalamic lobes. However, it is not clear to what extent these abnormalities are determined by the genetic liability for schizophrenia. OBJECTIVE To investigate thalamic volume and the presence of the adhesio interthalamica in monozygotic (MZ) twins concordant or discordant for schizophrenia. DESIGN Study of MZ twins. SETTING Patients were drawn from inpatient and outpatient clinics. Twin controls were recruited from a volunteer twin register and through media advertisements. PARTICIPANTS A total of 123 twins participated: 19 MZ twin pairs concordant for schizophrenia, 15 MZ schizophrenic twins and 16 MZ nonschizophrenic twins drawn from 17 pairs discordant for schizophrenia, and 27 MZ twin pairs without schizophrenia. Groups were matched for age, sex, handedness, level of education, parental socioeconomic status, and ethnicity. MAIN OUTCOME MEASURES The volume of the thalamus (including right and left hemispheres) was measured (in cubic centimeters) and the presence of the adhesio interthalamica was ascertained from structural magnetic resonance images. RESULTS Concordant twin pairs displayed significantly reduced thalamic volume compared with control twins, even when covarying for effects of whole-brain volume, age, and sex. There was a significant linear decrease in thalamic volume (control greater than discordant nonschizophrenic greater than discordant schizophrenic greater than concordant). In all groups, right thalamus was larger than left thalamus. There was no difference across groups in the frequency of the adhesio interthalamica. CONCLUSIONS Volumetric thalamic abnormalities in schizophrenia occur in twin pairs concordant for schizophrenia. These abnormalities may mark the substantial genetic contribution to the illness seen in concordant twin pairs, whereas the adhesio interthalamica is unlikely to be affected in schizophrenia.Arch Gen Psychiatry. 2007;64:401-409--></description><identifier>ISSN: 0003-990X</identifier><identifier>EISSN: 1538-3636</identifier><identifier>DOI: 10.1001/archpsyc.64.4.401</identifier><identifier>PMID: 17404117</identifier><identifier>CODEN: ARGPAQ</identifier><language>eng</language><publisher>Chicago, IL: American Medical Association</publisher><subject>Adult ; Adult and adolescent clinical studies ; Atrophy ; Biological and medical sciences ; Diseases in Twins - genetics ; Diseases in Twins - pathology ; Female ; Functional Laterality - physiology ; Humans ; Magnetic Resonance Imaging - statistics & numerical data ; Male ; Medical sciences ; Neural Pathways - pathology ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Schizophrenia ; Schizophrenia - genetics ; Schizophrenia - pathology ; Schizophrenia - physiopathology ; Sex Factors ; Thalamus - pathology ; Thalamus - physiopathology ; Twins, Monozygotic - genetics</subject><ispartof>Archives of general psychiatry, 2007-04, Vol.64 (4), p.401-409</ispartof><rights>2007 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a347t-82face6c30c71d35d0ed6376261f82fed7edfc08a35380c324e7d26df8e3c7bd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jamanetwork.com/journals/jamapsychiatry/articlepdf/10.1001/archpsyc.64.4.401$$EPDF$$P50$$Gama$$H</linktopdf><linktohtml>$$Uhttps://jamanetwork.com/journals/jamapsychiatry/fullarticle/10.1001/archpsyc.64.4.401$$EHTML$$P50$$Gama$$H</linktohtml><link.rule.ids>64,314,777,781,3327,27905,27906,76238,76241</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18695140$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17404117$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ettinger, Ulrich</creatorcontrib><creatorcontrib>Picchioni, Marco</creatorcontrib><creatorcontrib>Landau, Sabine</creatorcontrib><creatorcontrib>Matsumoto, Kazunori</creatorcontrib><creatorcontrib>van Haren, Neeltje E</creatorcontrib><creatorcontrib>Marshall, Nicolette</creatorcontrib><creatorcontrib>Hall, Mei-Hua</creatorcontrib><creatorcontrib>Schulze, Katja</creatorcontrib><creatorcontrib>Toulopoulou, Timothea</creatorcontrib><creatorcontrib>Davies, Nadia</creatorcontrib><creatorcontrib>Ribchester, Tracy</creatorcontrib><creatorcontrib>McGuire, Philip K</creatorcontrib><creatorcontrib>Murray, Robin M</creatorcontrib><title>Magnetic Resonance Imaging of the Thalamus and Adhesio Interthalamica in Twins With Schizophrenia</title><title>Archives of general psychiatry</title><addtitle>Arch Gen Psychiatry</addtitle><description>CONTEXT Abnormalities of the thalamus are thought to be central to the pathophysiology of schizophrenia. These abnormalities include altered structure and shape of the thalamus itself and possibly changes to the adhesio interthalamica (or massa intermedia), the gray matter bridge connecting the 2 thalamic lobes. However, it is not clear to what extent these abnormalities are determined by the genetic liability for schizophrenia. OBJECTIVE To investigate thalamic volume and the presence of the adhesio interthalamica in monozygotic (MZ) twins concordant or discordant for schizophrenia. DESIGN Study of MZ twins. SETTING Patients were drawn from inpatient and outpatient clinics. Twin controls were recruited from a volunteer twin register and through media advertisements. PARTICIPANTS A total of 123 twins participated: 19 MZ twin pairs concordant for schizophrenia, 15 MZ schizophrenic twins and 16 MZ nonschizophrenic twins drawn from 17 pairs discordant for schizophrenia, and 27 MZ twin pairs without schizophrenia. Groups were matched for age, sex, handedness, level of education, parental socioeconomic status, and ethnicity. MAIN OUTCOME MEASURES The volume of the thalamus (including right and left hemispheres) was measured (in cubic centimeters) and the presence of the adhesio interthalamica was ascertained from structural magnetic resonance images. RESULTS Concordant twin pairs displayed significantly reduced thalamic volume compared with control twins, even when covarying for effects of whole-brain volume, age, and sex. There was a significant linear decrease in thalamic volume (control greater than discordant nonschizophrenic greater than discordant schizophrenic greater than concordant). In all groups, right thalamus was larger than left thalamus. There was no difference across groups in the frequency of the adhesio interthalamica. CONCLUSIONS Volumetric thalamic abnormalities in schizophrenia occur in twin pairs concordant for schizophrenia. These abnormalities may mark the substantial genetic contribution to the illness seen in concordant twin pairs, whereas the adhesio interthalamica is unlikely to be affected in schizophrenia.Arch Gen Psychiatry. 2007;64:401-409--></description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Atrophy</subject><subject>Biological and medical sciences</subject><subject>Diseases in Twins - genetics</subject><subject>Diseases in Twins - pathology</subject><subject>Female</subject><subject>Functional Laterality - physiology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging - statistics & numerical data</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neural Pathways - pathology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Schizophrenia</subject><subject>Schizophrenia - genetics</subject><subject>Schizophrenia - pathology</subject><subject>Schizophrenia - physiopathology</subject><subject>Sex Factors</subject><subject>Thalamus - pathology</subject><subject>Thalamus - physiopathology</subject><subject>Twins, Monozygotic - genetics</subject><issn>0003-990X</issn><issn>1538-3636</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEFPGzEQhS1UVELoD-CCfCm3DeP1xt4co6iFSEFIENTeVoM9m3W1603tjRD8egxJi-YwGr3vzWgeY-cCJgJAXGEwzTa-mIkqJqlAHLGRmMoyk0qqL2wEADKbzeD3CTuN8U8aYaryr-xE6AIKIfSI4S1uPA3O8HuKvUdviC873Di_4X3Nh4b4usEWu13k6C2f24ai6_nSDxSGD8UZ5M7z9bPzkf9yQ8MfTONe-20TyDs8Y8c1tpG-HfqYPf78sV7cZKu76-VivspQFnrIyrxGQ8pIMFpYObVAVkmtciXqpJHVZGsDJcr0IBiZF6RtrmxdkjT6ycoxu9zv3Yb-747iUHUuGmpb9NTvYqVBSlClSqDYgyb0MQaqq21wHYaXSkD1nmv1L9dKFVUqEMlzcVi-e-rIfjoOQSbg-wHAaLCtQ0rSxU-uVLOpKCBx53sOO_yv5u9XZ_INV3KMNQ</recordid><startdate>20070401</startdate><enddate>20070401</enddate><creator>Ettinger, Ulrich</creator><creator>Picchioni, Marco</creator><creator>Landau, Sabine</creator><creator>Matsumoto, Kazunori</creator><creator>van Haren, Neeltje E</creator><creator>Marshall, Nicolette</creator><creator>Hall, Mei-Hua</creator><creator>Schulze, Katja</creator><creator>Toulopoulou, Timothea</creator><creator>Davies, Nadia</creator><creator>Ribchester, Tracy</creator><creator>McGuire, Philip K</creator><creator>Murray, Robin M</creator><general>American Medical Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070401</creationdate><title>Magnetic Resonance Imaging of the Thalamus and Adhesio Interthalamica in Twins With Schizophrenia</title><author>Ettinger, Ulrich ; Picchioni, Marco ; Landau, Sabine ; Matsumoto, Kazunori ; van Haren, Neeltje E ; Marshall, Nicolette ; Hall, Mei-Hua ; Schulze, Katja ; Toulopoulou, Timothea ; Davies, Nadia ; Ribchester, Tracy ; McGuire, Philip K ; Murray, Robin M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a347t-82face6c30c71d35d0ed6376261f82fed7edfc08a35380c324e7d26df8e3c7bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Atrophy</topic><topic>Biological and medical sciences</topic><topic>Diseases in Twins - genetics</topic><topic>Diseases in Twins - pathology</topic><topic>Female</topic><topic>Functional Laterality - physiology</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging - statistics & numerical data</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neural Pathways - pathology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Schizophrenia</topic><topic>Schizophrenia - genetics</topic><topic>Schizophrenia - pathology</topic><topic>Schizophrenia - physiopathology</topic><topic>Sex Factors</topic><topic>Thalamus - pathology</topic><topic>Thalamus - physiopathology</topic><topic>Twins, Monozygotic - genetics</topic><toplevel>online_resources</toplevel><creatorcontrib>Ettinger, Ulrich</creatorcontrib><creatorcontrib>Picchioni, Marco</creatorcontrib><creatorcontrib>Landau, Sabine</creatorcontrib><creatorcontrib>Matsumoto, Kazunori</creatorcontrib><creatorcontrib>van Haren, Neeltje E</creatorcontrib><creatorcontrib>Marshall, Nicolette</creatorcontrib><creatorcontrib>Hall, Mei-Hua</creatorcontrib><creatorcontrib>Schulze, Katja</creatorcontrib><creatorcontrib>Toulopoulou, Timothea</creatorcontrib><creatorcontrib>Davies, Nadia</creatorcontrib><creatorcontrib>Ribchester, Tracy</creatorcontrib><creatorcontrib>McGuire, Philip K</creatorcontrib><creatorcontrib>Murray, Robin M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of general psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ettinger, Ulrich</au><au>Picchioni, Marco</au><au>Landau, Sabine</au><au>Matsumoto, Kazunori</au><au>van Haren, Neeltje E</au><au>Marshall, Nicolette</au><au>Hall, Mei-Hua</au><au>Schulze, Katja</au><au>Toulopoulou, Timothea</au><au>Davies, Nadia</au><au>Ribchester, Tracy</au><au>McGuire, Philip K</au><au>Murray, Robin M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Magnetic Resonance Imaging of the Thalamus and Adhesio Interthalamica in Twins With Schizophrenia</atitle><jtitle>Archives of general psychiatry</jtitle><addtitle>Arch Gen Psychiatry</addtitle><date>2007-04-01</date><risdate>2007</risdate><volume>64</volume><issue>4</issue><spage>401</spage><epage>409</epage><pages>401-409</pages><issn>0003-990X</issn><eissn>1538-3636</eissn><coden>ARGPAQ</coden><abstract>CONTEXT Abnormalities of the thalamus are thought to be central to the pathophysiology of schizophrenia. These abnormalities include altered structure and shape of the thalamus itself and possibly changes to the adhesio interthalamica (or massa intermedia), the gray matter bridge connecting the 2 thalamic lobes. However, it is not clear to what extent these abnormalities are determined by the genetic liability for schizophrenia. OBJECTIVE To investigate thalamic volume and the presence of the adhesio interthalamica in monozygotic (MZ) twins concordant or discordant for schizophrenia. DESIGN Study of MZ twins. SETTING Patients were drawn from inpatient and outpatient clinics. Twin controls were recruited from a volunteer twin register and through media advertisements. PARTICIPANTS A total of 123 twins participated: 19 MZ twin pairs concordant for schizophrenia, 15 MZ schizophrenic twins and 16 MZ nonschizophrenic twins drawn from 17 pairs discordant for schizophrenia, and 27 MZ twin pairs without schizophrenia. Groups were matched for age, sex, handedness, level of education, parental socioeconomic status, and ethnicity. MAIN OUTCOME MEASURES The volume of the thalamus (including right and left hemispheres) was measured (in cubic centimeters) and the presence of the adhesio interthalamica was ascertained from structural magnetic resonance images. RESULTS Concordant twin pairs displayed significantly reduced thalamic volume compared with control twins, even when covarying for effects of whole-brain volume, age, and sex. There was a significant linear decrease in thalamic volume (control greater than discordant nonschizophrenic greater than discordant schizophrenic greater than concordant). In all groups, right thalamus was larger than left thalamus. There was no difference across groups in the frequency of the adhesio interthalamica. CONCLUSIONS Volumetric thalamic abnormalities in schizophrenia occur in twin pairs concordant for schizophrenia. These abnormalities may mark the substantial genetic contribution to the illness seen in concordant twin pairs, whereas the adhesio interthalamica is unlikely to be affected in schizophrenia.Arch Gen Psychiatry. 2007;64:401-409--></abstract><cop>Chicago, IL</cop><pub>American Medical Association</pub><pmid>17404117</pmid><doi>10.1001/archpsyc.64.4.401</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult Adult and adolescent clinical studies Atrophy Biological and medical sciences Diseases in Twins - genetics Diseases in Twins - pathology Female Functional Laterality - physiology Humans Magnetic Resonance Imaging - statistics & numerical data Male Medical sciences Neural Pathways - pathology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Schizophrenia Schizophrenia - genetics Schizophrenia - pathology Schizophrenia - physiopathology Sex Factors Thalamus - pathology Thalamus - physiopathology Twins, Monozygotic - genetics |
| title | Magnetic Resonance Imaging of the Thalamus and Adhesio Interthalamica in Twins With Schizophrenia |
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