Aromatase Expression Was Not Detected by Immunohistochemistry in Endometrial Cancer
: Several studies suggested that aromatase could play an important role in tumor progression and prognosis in endometrial cancer because androstenedione is converted to estrogen by the enzyme. For better understanding of the aromatase expression in endometrial cancer and its relation to diverse cli...
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| Veröffentlicht in: | Annals of the New York Academy of Sciences 2007-01, Vol.1095 (1), p.70-75 |
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| container_title | Annals of the New York Academy of Sciences |
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| creator | JEON, YONG-TARK PARK, SO YEON KIM, YONG-BEOM KIM, JAE WEON PARK, NOH-HYUN KANG, SOON-BEOM LEE, HYO-PYO SONG, YONG-SANG |
| description | : Several studies suggested that aromatase could play an important role in tumor progression and prognosis in endometrial cancer because androstenedione is converted to estrogen by the enzyme. For better understanding of the aromatase expression in endometrial cancer and its relation to diverse clinicopathological parameters, we conducted this study. This study was carried out with 141 endometrial cancer patients, all of whom had undergone operations in our institution from 1993 to 2002. Paraffin‐embedded tissue blocks were sectioned and immunostained with monoclonal antiaromatase antibody using human placental tissue as positive control. Clinicopathological variables of all patients were also reviewed. Despite quite a high aromatase expression in positive control, there was no endometrial cancer specimen showing the enzyme expression. Our result, although needs further investigation on the cause of the difference from other studies, suggested that aromatase might not have an important role in endometrial cancer. |
| doi_str_mv | 10.1196/annals.1397.010 |
| format | Article |
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For better understanding of the aromatase expression in endometrial cancer and its relation to diverse clinicopathological parameters, we conducted this study. This study was carried out with 141 endometrial cancer patients, all of whom had undergone operations in our institution from 1993 to 2002. Paraffin‐embedded tissue blocks were sectioned and immunostained with monoclonal antiaromatase antibody using human placental tissue as positive control. Clinicopathological variables of all patients were also reviewed. Despite quite a high aromatase expression in positive control, there was no endometrial cancer specimen showing the enzyme expression. 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Our result, although needs further investigation on the cause of the difference from other studies, suggested that aromatase might not have an important role in endometrial cancer.</description><subject>Adult</subject><subject>Aged</subject><subject>aromatase</subject><subject>Aromatase - biosynthesis</subject><subject>Aromatase - genetics</subject><subject>Aromatase - physiology</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biomarkers, Tumor - physiology</subject><subject>endometrial cancer</subject><subject>Endometrial Neoplasms - enzymology</subject><subject>Endometrial Neoplasms - genetics</subject><subject>Endometrial Neoplasms - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Middle Aged</subject><subject>Placenta - enzymology</subject><issn>0077-8923</issn><issn>1749-6632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDFv2zAQhYmiQe0mnbsVnLrJOZKSKI6G47gODGdIAiNZCIo6I2ol0SVl1P73pSOjHTPd8r2Hdx8hXxlMGFP5tek604QJE0pOgMEHMmYyVUmeC_6RjAGkTArFxYh8DuEnAONFKj-RUYQgBabG5GHqXWt6E5DODzuPIdSuoxsT6Nr19AZ7tD1WtDzSZdvuO_dah97ZV2zj9Udad3TeVa7F3temoTPTWfRX5GIbV-GX870kT7fzx9mPZHW_WM6mq8RyxSHJlLQlcOCVASHy1EqVlWorDS-4lcLkYAUvQfFMFgKRCyhtJoUCWajq9NUl-T707rz7vcfQ67jKYtOYDt0-aBlrIU8hgtcDaL0LweNW73zdGn_UDPTJox486pNHHT3GxLdz9b5ssfrPn8VFQAzAn7rB43t9ev08fXirTYZUtIeHfynjf-lcCpnpzXqh715uNmrBuM7FX_d8jiw</recordid><startdate>200701</startdate><enddate>200701</enddate><creator>JEON, YONG-TARK</creator><creator>PARK, SO YEON</creator><creator>KIM, YONG-BEOM</creator><creator>KIM, JAE WEON</creator><creator>PARK, NOH-HYUN</creator><creator>KANG, SOON-BEOM</creator><creator>LEE, HYO-PYO</creator><creator>SONG, YONG-SANG</creator><general>Blackwell Publishing Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200701</creationdate><title>Aromatase Expression Was Not Detected by Immunohistochemistry in Endometrial Cancer</title><author>JEON, YONG-TARK ; PARK, SO YEON ; KIM, YONG-BEOM ; KIM, JAE WEON ; PARK, NOH-HYUN ; KANG, SOON-BEOM ; LEE, HYO-PYO ; SONG, YONG-SANG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2920-597cb0202da03364c795b9f7a282c73a60c32b0925783ee230bc57390789d8923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Aged</topic><topic>aromatase</topic><topic>Aromatase - biosynthesis</topic><topic>Aromatase - genetics</topic><topic>Aromatase - physiology</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Biomarkers, Tumor - physiology</topic><topic>endometrial cancer</topic><topic>Endometrial Neoplasms - enzymology</topic><topic>Endometrial Neoplasms - genetics</topic><topic>Endometrial Neoplasms - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Middle Aged</topic><topic>Placenta - enzymology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>JEON, YONG-TARK</creatorcontrib><creatorcontrib>PARK, SO YEON</creatorcontrib><creatorcontrib>KIM, YONG-BEOM</creatorcontrib><creatorcontrib>KIM, JAE WEON</creatorcontrib><creatorcontrib>PARK, NOH-HYUN</creatorcontrib><creatorcontrib>KANG, SOON-BEOM</creatorcontrib><creatorcontrib>LEE, HYO-PYO</creatorcontrib><creatorcontrib>SONG, YONG-SANG</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of the New York Academy of Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>JEON, YONG-TARK</au><au>PARK, SO YEON</au><au>KIM, YONG-BEOM</au><au>KIM, JAE WEON</au><au>PARK, NOH-HYUN</au><au>KANG, SOON-BEOM</au><au>LEE, HYO-PYO</au><au>SONG, YONG-SANG</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aromatase Expression Was Not Detected by Immunohistochemistry in Endometrial Cancer</atitle><jtitle>Annals of the New York Academy of Sciences</jtitle><addtitle>Ann N Y Acad Sci</addtitle><date>2007-01</date><risdate>2007</risdate><volume>1095</volume><issue>1</issue><spage>70</spage><epage>75</epage><pages>70-75</pages><issn>0077-8923</issn><eissn>1749-6632</eissn><abstract>: Several studies suggested that aromatase could play an important role in tumor progression and prognosis in endometrial cancer because androstenedione is converted to estrogen by the enzyme. 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| subjects | Adult Aged aromatase Aromatase - biosynthesis Aromatase - genetics Aromatase - physiology Biomarkers, Tumor - genetics Biomarkers, Tumor - physiology endometrial cancer Endometrial Neoplasms - enzymology Endometrial Neoplasms - genetics Endometrial Neoplasms - pathology Female Humans Immunohistochemistry Middle Aged Placenta - enzymology |
| title | Aromatase Expression Was Not Detected by Immunohistochemistry in Endometrial Cancer |
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