Potentially oncogenic B-cell activation–induced smaller isoforms of FOXP1 are highly expressed in the activated B cell–like subtype of DLBCL

The FOXP1 forkhead transcription factor is targeted by recurrent chromosome translocations in several subtypes of B-cell non-Hodgkin lymphomas, where high-level FOXP1 protein expression has been linked to a poor prognosis. Western blotting studies of diffuse large B-cell lymphoma (DLBCL) cell lines...

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Veröffentlicht in:	Blood 2008-03, Vol.111 (5), p.2816-2824
Hauptverfasser:	Brown, Philip J., Ashe, Sally L., Leich, Ellen, Burek, Christof, Barrans, Sharon, Fenton, James A., Jack, Andrew S., Pulford, Karen, Rosenwald, Andreas, Banham, Alison H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing - genetics Antibodies, Monoclonal B-Lymphocytes - immunology Biological and medical sciences Biopsy Blotting, Western Cell Line, Tumor Exons - genetics Forkhead Transcription Factors - genetics Forkhead Transcription Factors - immunology Gene Expression Profiling Gene Expression Regulation, Neoplastic Hematologic and hematopoietic diseases Humans Immunohistochemistry Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphocyte Activation - immunology Lymphoma, Large B-Cell, Diffuse - classification Lymphoma, Large B-Cell, Diffuse - genetics Lymphoma, Large B-Cell, Diffuse - immunology Medical sciences Peroxidases - metabolism Protein Isoforms - genetics Protein Isoforms - immunology Repressor Proteins - genetics Repressor Proteins - immunology
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